NU9056
Based on 7 publication(s) in Google Scholar
NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells.
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- Pureza: 96.62%
- No. CAS: 1450644-28-6
- Fòrmula: C6H4N2S4
- Peso molecular:232.37
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Almacenamiento:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Apoptosis Compound Library
HY-L003
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
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Anti-Prostate Cancer Compound Library
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Highly Selective Inhibitors Library
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Cell Death Library
HY-L162
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Publications Citing Use of MedChemExpress (MCE) NU9056
More- Nature. 2023 Oct;622(7981):173-179. [Abstract]
- Cell Host Microbe. 2026 Jun 3:S1931-3128(26)00181-2. [Abstract]
- Adv Sci (Weinh). 2024 Jul 9:e2406333. [Abstract]
- Cancer Lett. 2024 Jun 14:597:217005. [Abstract]
- Sens Actuators B Chem. 2024 Aug 1, 412, 135827.
- Mol Cell Proteomics. 2023 Mar;22(3):100504. [Abstract]
- Fish Shellfish Immunol. 2025 Oct 16:168:110946. [Abstract]
Customer Validation & Images
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RT-PCR
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WB
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Bio/Physico-chemical Assay
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WB
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Bio/Physico-chemical Assay
Actividad biológica
NU9056 (17-36 μM; 24-96 hours) results in both caspase 3 and caspase 9 activation in a time- and concentration-dependent manner[1].
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NU9056 (2.5-40 μM; 2 hours) treatment results in decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation[1].
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NU9056 treatment also decreases androgen receptor, prostate specific antigen, p53 and p21 protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP cells
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Concentration:17 µM, 24 µM, 36 µM
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Incubation Time:24 hours, 48 hours, 72 hours, 96 hours
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Result:Induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner.
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Cell Line:LNCaP cells
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Concentration:2.5 µM, 5 µM, 10 µM, 20 µM, 40 µM
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Incubation Time:2 hours
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Result:Resulted in decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1450644-28-6
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Appearance Liquid (Density: 1.60±0.1 g/cm3)
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Peso molecular 232.37
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Fòrmula C6H4N2S4
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Color Yellow to brown
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SMILES
C1(SSC2=CC=NS2)=CC=NS1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (7)
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Journal Impact Factor
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Most Recent
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Nature
2023 Oct;622(7981):173-179. PMID: 37731000
NU9056 purchased from MedChemExpress. Usage Cited in: Nature. 2023 Oct;622(7981):173-179. [Abstract]
Representative western blots of two biological replicates of HEK293T histones treated with A-485 and NU9056 (10 μM for 24 hours).
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Cell Host Microbe
Uric acid promotes dietary lipid absorption through microbiome and metabolomic remodeling via a liver-gut endocrine axis. [Abstract]2026 Jun 3:S1931-3128(26)00181-2. PMID: 42235504 -
Adv Sci (Weinh)
Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. [Abstract]2024 Jul 9:e2406333. PMID: 38981044
NU9056 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jul 9:e2406333. [Abstract]
H1299 cells were treated with lactate, A‐485, KAT8‐IN‐1, NU9056 (2 µM), Butyrolactone 3 (MB‐3), or Gln‐AMS for 14 h. Quantitative analysis of extracellular FFAs was conducted post‐treatment.
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Cancer Lett
Acetylation-dependent deubiquitinase USP26 stabilizes BAG3 to promote breast cancer progression. [Abstract]2024 Jun 14:597:217005. PMID: 38880224
NU9056 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2024 Jun 14:597:217005. [Abstract]
Treatment with the Tip60 inhibitor NU9056 (20 μM for 18 h) reduced USP26 acetylation. Input and anti-HA immunoprecipitates from HEK293T cells transfected with or without Flag-Tip60 were analyzed by WB.
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NU9056 purchased from MedChemExpress. Usage Cited in: Sens Actuators B Chem. 2024 Aug 1, 412, 135827.
The effects of adding NU9056 (0-500 μM) to the Tip60 reaction system were analyzed for fluorescence readout and for UV–vis absorbance readout.
NU9056 purchased from MedChemExpress. Usage Cited in: Sens Actuators B Chem. 2024 Aug 1, 412, 135827.
Kinetic plots displaying the corresponding relative activity based on fluorescence readout and UV–vis absorbance readout are presented, plotted against the logarithm of NU9056 (0-50 μM) concentrations.
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Mol Cell Proteomics
P300 interacted with N-Myc and regulated its protein stability via altering its posttranslational modifications in neuroblastoma. [Abstract]2023 Mar;22(3):100504. PMID: 36708875 -
Fish Shellfish Immunol
Grass carp (Ctenopharyngodon idella) Kat5 mediates P53 acetylation to induce apoptosis and promotes GCRV replication. [Abstract]2025 Oct 16:168:110946. PMID: 41109541
NU9056 purchased from MedChemExpress. Usage Cited in: Fish Shellfish Immunol. 2025 Oct 16:168:110946. [Abstract]
The healthy grass carp were separately intraperitoneally injected with 21 μl of NU9056 at a concentration of 20 mM or the same amount of DMSO. After 4 days, the tissues of intestines, liver, spleen, and kidney were separately extracted. The mRNA levels of bax, bcl2, and caspase3 were assessed by qRT-PCR.
NU9056 purchased from MedChemExpress. Usage Cited in: Fish Shellfish Immunol. 2025 Oct 16:168:110946. [Abstract]
The healthy grass carp were separately intraperitoneally injected with 21 μl of NU9056 at a concentration of 20 mM or the same amount of DMSO. After 4 days, the tissues of intestines, liver, spleen, and kidney were separately extracted. Caspase3 protein levels were analyzed by Western-blot.
Solvente y solubilidad
DMSO : ≥ 125 mg/mL (537.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Kelly Coffey, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One. 2012;7(10):e45539. [Content Brief]
[2]. Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5(5):ENEURO.0378-18.2018. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3035 mL | 21.5174 mL | 43.0348 mL | 107.5870 mL |
| 5 mM | 0.8607 mL | 4.3035 mL | 8.6070 mL | 21.5174 mL | |
| 10 mM | 0.4303 mL | 2.1517 mL | 4.3035 mL | 10.7587 mL | |
| 15 mM | 0.2869 mL | 1.4345 mL | 2.8690 mL | 7.1725 mL | |
| 20 mM | 0.2152 mL | 1.0759 mL | 2.1517 mL | 5.3794 mL | |
| 25 mM | 0.1721 mL | 0.8607 mL | 1.7214 mL | 4.3035 mL | |
| 30 mM | 0.1434 mL | 0.7172 mL | 1.4345 mL | 3.5862 mL | |
| 40 mM | 0.1076 mL | 0.5379 mL | 1.0759 mL | 2.6897 mL | |
| 50 mM | 0.0861 mL | 0.4303 mL | 0.8607 mL | 2.1517 mL | |
| 60 mM | 0.0717 mL | 0.3586 mL | 0.7172 mL | 1.7931 mL | |
| 80 mM | 0.0538 mL | 0.2690 mL | 0.5379 mL | 1.3448 mL | |
| 100 mM | 0.0430 mL | 0.2152 mL | 0.4303 mL | 1.0759 mL |
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