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Referencia número: HY-138976

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NV-5440

NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake.

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No. CAS: 2226614-88-4
Fòrmula: C₃₁H₃₆N₆O₃S
Peso molecular:572.73

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

NV-5440 Chemical Structure

No. CAS: 2226614-88-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

mTORC1

GLUT1

GLUT2

GLUT3

GLUT4

Ver todos los productos específicos de isoformas mTOR :

Ver todos los productos específicos de isoformas GLUT :

In Vitro

NV-5440 potently inhibits ³H-2DG uptake in MCF7 cells with an IC₅₀ of 36 nM, and targets GLUT-1 through GLUT-4 but not GLUT-5^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NV-5440 (30 mg/kg; i.p.) inhibits mTORC1 activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[2]
Dosage:

30 mg/kg
Administration:

i.p.
Result:

Confirmed inhibition of
mTORC1 activity.

Chemical Information

No. CAS 2226614-88-4
Peso molecular 572.73
Fòrmula C₃₁H₃₆N₆O₃S
SMILES

N#CC=1C=CC=CC1N2CCN(CC3=CC(C(=O)N4CCN(C=5C=CC=CC5S(=O)(=O)N)CC4)=C(C=C3C)C)CC2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. David John O'neill, et al. PHENYL mTORC INHIBITORS AND USES THEREOF. WO2018089433A1. https://patents.google.com/patent/WO2018089433A1/en?oq=WO2018089433+A1

[2]. Reckzeh ES, et al. Small-Molecule Inhibition of Glucose Transporters GLUT-1-4. Chembiochem. 2020;21(1-2):45-52. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
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NV-5440

Ver todos los productos específicos de isoformas mTOR

Ver todos los productos específicos de isoformas GLUT

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

NV-5440 Related Classifications

HY-138976 Related Classifications