country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-138976

Copy Link Print Information

NV-5440

NV-5440 (Compound I-120) is an mTORC1 inhibitor and glucose transporter inhibitor. NV-5440 targets GLUT-1, -2, -3, and -4, and shows no activity against GLUT-5. NV-5440 inhibits glucose uptake.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2226614-88-4
Fòrmula: C₃₁H₃₆N₆O₃S
Peso molecular:572.73

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

NV-5440 Chemical Structure

No. CAS: 2226614-88-4

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

mTORC1

GLUT1

GLUT2

GLUT3

GLUT4

Ver todos los productos específicos de isoformas mTOR :

Ver todos los productos específicos de isoformas GLUT :

In Vitro

NV-5440 potently inhibits ³H-2DG uptake in MCF7 cells with an IC₅₀ of 36 nM, and targets GLUT-1 through GLUT-4 but not GLUT-5^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NV-5440 (30 mg/kg; i.p.) inhibits mTORC1 activity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[2]
Dosage:

30 mg/kg
Administration:

i.p.
Result:

Confirmed inhibition of
mTORC1 activity.

Chemical Information

No. CAS 2226614-88-4
Peso molecular 572.73
Fòrmula C₃₁H₃₆N₆O₃S
SMILES

N#CC=1C=CC=CC1N2CCN(CC3=CC(C(=O)N4CCN(C=5C=CC=CC5S(=O)(=O)N)CC4)=C(C=C3C)C)CC2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. David John O'neill, et al. PHENYL mTORC INHIBITORS AND USES THEREOF. WO2018089433A1. https://patents.google.com/patent/WO2018089433A1/en?oq=WO2018089433+A1

[2]. Reckzeh ES, et al. Small-Molecule Inhibition of Glucose Transporters GLUT-1-4. Chembiochem. 2020;21(1-2):45-52. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

NV-5440

Ver todos los productos específicos de isoformas mTOR

Ver todos los productos específicos de isoformas GLUT