PIK-C98
PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma.
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- No. CAS: 691388-62-2
- Fòrmula: C16H10Cl2N2OS
- Peso molecular:349.23
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
PI3Kα 0.59 μM (IC50) |
PI3Kβ 1.64 μM (IC50) |
PI3Kδ 3.65 μM (IC50) |
PI3Kγ 0.74 μM (IC50) |
Chemical Information
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No. CAS 691388-62-2
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Peso molecular 349.23
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Fòrmula C16H10Cl2N2OS
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SMILES
N#C/C(C(N)=S)=C\C=C\C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PIK-C98 Related Classifications
HY-12491 Related Classifications
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