Rudolfomycin
Rudolfomycin is an anthracycline Antibiotic, composed of the aglycone ε-pyrromycinone and three glycosyl sugar units. Rudolfomycin inhibits the growth of mammalian tumors and exhibits antibacterial activity against Gram-positive bacteria. Rudolfomycin can be used in the research of leukemia and Gram-positive bacterial infections.
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- No. CAS: 69245-38-1
- Fòrmula: C42H52N2O16
- Peso molecular:840.87
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Rudolfomycin (0.25-8 μg/mL) potently inhibits the growth of gram-positive bacteria including Streptococcus pneumoniae A-9585 (MIC 0.25 μg/mL), Streptococcus pyogenes A-9604 (MIC 0.5 μg/mL), Staphylococcus aureus A-9537 (MIC 2 μg/mL), Staphylococcus aureus A-9606 (MIC 8 μg/mL), and Streptococcus faecalis A-20688 (MIC 4 μg/mL), but is inactive against gram-negative bacteria and most tested fungi[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BDF1 mice (female; implanted i.p. with 106 L-1210 leukemia ascites cells)[1]
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Dosage:12.8, 6.4, 3.2, 1.6, 0.8, 0.4 mg/kg
6.4, 3.2, 1.6, 0.8, 0.4, 0.2 mg/kg
3.2, 1.6, 0.8, 0.4, 0.2, 0.1 mg/kg
1.6, 0.8, 0.4, 0.2, 0.1, 0.05 mg/kg -
Administration:i.p.; single dose
i.p.; days 1, 4, 7
i.p.; daily, 5 days
i.p.; daily, 9 days -
Result:Attained the peak median survival time (MST) of 10.0 days and maximal % T/C value of 143 across single intraperitoneal (i.p.) bolus, intermittent day 1/4/7 i.p., 5-day daily i.p. and 9-day daily i.p. schedules at corresponding medium dose groups.
Attained a secondary MST of 9.5 days with a % T/C of 136 only in the day 1/4/7 intermittent i.p. group treated with 0.8 mg/kg.
Attained a consistent MST of 9.0 days and % T/C of 129 at multiple dosages covering all four administration modes.
Attained a uniform MST of 8.0 days and % T/C of 114 across low-dose cohorts of all four dosing regimens.
Attained a moderate MST of 7.5 days with a % T/C of 107 in the 9-day daily i.p. group at 1.6 and 0.1 mg/kg.
Attained the lowest MST of 7.0 days with a % T/C of 100 under day 1/4/7 intermittent i.p. administration at 3.2 mg/kg.
Chemical Information
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No. CAS 69245-38-1
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Peso molecular 840.87
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Fòrmula C42H52N2O16
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SMILES
O=C(C1[C@@](O)(CC)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4C(N)=CC([C@@H](C)O4)=O)[C@H](C)O3)[C@H](C)O2)C5=C(O)C6=C(C(C7=C(O)C=CC(O)=C7C6=O)=O)C=C15)OC
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Structure Classification
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Initial Source
Actinosporangium species ATCC 31127
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rudolfomycin Related Classifications
HY-126731 Related Classifications
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