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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Referencia número: HY-149940
No. CAS: 2708270-99-7
SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC50 value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice .
Referencia número: HY-152075
No. CAS: 2947506-65-0
Target:
Áreas de investigación:
AXL-IN-14 is a potent and orally active AXL inhibitor with an IC50 value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity .
Referencia número: HY-157546
Target:
Áreas de investigación:
VEGFR-2-IN-40 is a VEGFR-2 inhibitor. VEGFR-2-IN-40 boosts early and late apoptosis. VEGFR-2-IN-40 decreases the levels immunomodulatory proteins TNF-α and IL-6 while showing a four-fold rise in an apoptotic marker caspase-3 .
Referencia número: HY-160980
No. CAS: 95105-77-4
Target:
Áreas de investigación:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Sornidipine is a calcium channel blocker. Sornidipine also reduces neurogenic inflammation. Sornidipine reduces the inflow of calcium ions into cells by blocking L-type calcium channels, thereby reducing the contraction of vascular smooth muscle, leading to vasodilation and decreased blood pressure. Sornidipine can be used to study the cardiovascular system especially in hypertension and related cardiovascular diseases .
Referencia número: HY-161429
No. CAS: 2152667-21-3
Target:
Áreas de investigación:
Antidiabetic agent 5 (compound S1) is a antidiabetic agent. Antidiabetic agent 5 inhibits the activity of α-glucosidase and α-amylase with IC50 values of 3.91，8.89 μM，respectively. Antidiabetic agent 5 decreases sugar levels. Antidiabetic agent 5 has the potential for the research of type-II diabetes .
Referencia número: HY-161458
Target:
Áreas de investigación:
GSK-3β inhibitor 16 (compound 7c) is a GSK-3β inhibitor with the IC50 of 4.68 nM. GSK-3β inhibitor 16 decreases Tau hyperphosphorylated aggregate and alleviates cognitive impairments in the Scopolamin (HY-N0296)-induced model in mice .
Referencia número: HY-162622
Target:
Áreas de investigación:
BET-IN-26 (compound 13a) is a potent, selective and orally active BD1 inhibitor with IC50 values of 0.0055, 9.0 µM for BD1, BD2, respectively. BET-IN-26 decreases LPS (HY-D1056) induced serum levels of IL-6 and MCP-1 .
Referencia número: HY-16516R
No. CAS: 1085703-32-7
Áreas de investigación:
Vitamin CK3 (Standard) is the combination of Vitamin C and vitamin K3 (100:1 ratio). Vitamin CK3 (Standard) can decrease MMP activity. Vitamin CK3 (Standard) can reactivate DNases and cause cell autophagy. Vitamin CK3 (Standard) can be used for the research of cancer, such as lung cancer .
Referencia número: HY-172786
No. CAS: 1984421-81-9
Áreas de investigación:
Caspase-3-IN-3 (compound 7) is a caspase 3 inhibitor. Caspase-3-IN-3 increases cellular ATP levels, inhibits caspase-3 activity, decreases nitrite production, suppresses cytokine-induced apoptosis, and restores Glucose (HY-B0389)-stimulated insulin secretion .
Referencia número: HY-175398
No. CAS: 2201798-21-0
Target:
Áreas de investigación:
OZO-Cl is an OZO derivative. OZO-Cl has anti-cancer activity. OZO-Cl significantly decreases the intracellular glutathion S-transferase Pi (GST) activity. OZO-Cl exhibits cytotoxicity to cancer cell lines, with IC50s of 150 and 120 μmol/L in Panc-1 and K562 cells respectively .
Referencia número: HY-18209
No. CAS: 193420-09-6
Áreas de investigación:
Z-13752A is a mercaptopropanoyl amino acid. Z-13752A inhibits NEP and ACE, with Ki values of 1.8 and 3.2 nM, respectively. Z-13752A decreases the arterial blood pressure and increases coronary blood flow. Z-13752A can be used in the research of coronary artery occlusion .
Referencia número: HY-A0060
No. CAS: 59937-28-9
Synonyms: NKK 105
Target:
Áreas de investigación:
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .
Referencia número: HY-A0122R
No. CAS: 18378-89-7
Synonyms: Mithramycin A (Standard)
Plicamycin (Standard) is the analytical standard of Plicamycin (HY-A0122). This product is intended for research and analytical applications. Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression .
Referencia número: HY-B0264S1
No. CAS: 1329563-41-8
Referencia número: HY-B0310R
No. CAS: 76963-41-2
Áreas de investigación:
Nizatidine (Standard) is the analytical standard of Nizatidine. This product is intended for research and analytical applications. Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach and intestines ulcers. Nizatidine works by decreasing the secretion of gastric acid the stomach makes and prevent ulcers from coming back after they have healed in animal models .
Referencia número: HY-B0588AS
Synonyms: AL-4862-d5 hydrochloride
Referencia número: HY-B0589S
No. CAS: 222412-82-0
Referencia número: HY-N1280
No. CAS: 129280-33-7
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Glycyrrhiza uralensis Fisch. Extract Phenols Polyphenols Isoflavones
Target:
Referencia número: HY-N21573
No. CAS: 34391-10-1
Target:
Referencia número: HY-N8413
No. CAS: 1449382-91-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
