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Referencia número: HY-N21846

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U-62162

U-62162 is an Antibiotic. U-62162 is found in Streptomyces verdensis. U-62162 inhibits the growth of Gram-positive bacteria. U-62162 exhibits no in vivo protective effect in animals with experimental S. aureus infection.

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No. CAS: 82516-67-4
Fòrmula: C₂₃H₃₃NO₆
Peso molecular:419.51

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

U-62162 Chemical Structure

No. CAS: 82516-67-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
- In Vitro
- In Vivo
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

Microbial Metabolite

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In Vitro

U-62162 exhibits the most potent in vitro growth inhibitory activity against three strains of Staphylococcus aureus, with an MIC of 1.0 μg/mL, and shows selective activity against Gram-positive bacteria with no meaningful activity against the tested Gram-negative strains^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The maximum tolerated dose of U-62162 (8-12.5 mg/kg/day; i.p.) in healthy animals is 12.5 mg/kg/day, and at a dose of 8 mg/kg/day, it exhibits no in vivo protective efficacy against S. aureus infection in mice.^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

strain not specified^[1]
Dosage:

12.5 mg/kg/day (healthy animals); 8 mg/kg/day (S. aureus-infected animals)
Administration:

i.p.
Result:

Detected no animal protection at the 8 mg/kg/day dose in S. aureus-infected mice.

Related Protocols :

Chemical Information

No. CAS 82516-67-4
Peso molecular 419.51
Fòrmula C₂₃H₃₃NO₆
SMILES

O=C(NC1=CC(CCCCC(O)=O)(C2OC2C1=O)O)/C=C/C(CC(C)/C=C(C)\C)C
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces verdensis
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Slechta L, et al. Isolation and characterization of a new antibiotic U-62162. J Antibiot (Tokyo). 1982 May;35(5):556-60. [Content Brief]

[2]. Alcaraz L, et al. The first synthesis of the Streptomyces derived antibiotic U-62162[J]. Chemical Communications, 1998, 34(10): 1157-1158.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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U-62162

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