VU6001376
VU6001376 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4 PAM) with an EC50 of 50.1 nM.
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- No. CAS: 1968546-34-0
- Fòrmula: C18H14F2N6OS
- Peso molecular:400.41
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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mGlu4 50.1 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
50.1 nM
Compound: 27o; VU6001376
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Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization preincubated for 142 secs followed by EC20 glutamate addition and subsequent EC80 glutamate add
Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mobilization preincubated for 142 secs followed by EC20 glutamate addition and subsequent EC80 glutamate add
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[PMID: 30247901] |
Chemical Information
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No. CAS 1968546-34-0
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Peso molecular 400.41
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Fòrmula C18H14F2N6OS
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SMILES
O=C(NC1CC(F)(F)C1)C2=NSC3=CC(NC4=NNC5=C4N=CC=C5)=CC=C32
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU6001376 Related Classifications
HY-112814 Related Classifications
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