2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Mitochondrial Metabolism Caspase
  4. GD3 Ganglioside

GD3 Ganglioside is an Apoptosis inducer and a biomarker for mouse neural stem cells. GD3 Ganglioside expresses in neural stem cells and the subventricular zone of the adult mouse brain. GD3 Ganglioside targets the mitochondrial permeability transition pore complex, induces pore opening, dissipates mitochondrial transmembrane potential, triggers Mitochondrial swelling, releases pro-apoptotic factors, and activates Caspase-9. GD3 Ganglioside is applicable to research related to glioblastoma.

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GD3 Ganglioside

GD3 Ganglioside Chemical Structure

CAS No. : 62010-37-1

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Other Forms of GD3 Ganglioside:

GD3 Ganglioside Related Antibodies

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Description

GD3 Ganglioside is an Apoptosis inducer and a biomarker for mouse neural stem cells. GD3 Ganglioside expresses in neural stem cells and the subventricular zone of the adult mouse brain. GD3 Ganglioside targets the mitochondrial permeability transition pore complex, induces pore opening, dissipates mitochondrial transmembrane potential, triggers Mitochondrial swelling, releases pro-apoptotic factors, and activates Caspase-9. GD3 Ganglioside is applicable to research related to glioblastoma[1][2][3].

IC50 & Target[1]

Caspase-9

 

In Vitro

GD3 ganglioside (20 μM) induces rapid swelling of isolated rat liver mitochondria by opening the mitochondrial permeability transition pore complex[2].
GD3 ganglioside (200 μM; 6 h) induces caspase 9 activation in empty vector-transfected T-cell lymphoma CEM cells, and this effect is completely abrogated by forced expression of bcl-2[2].
GD3 ganglioside (200 μM; up to 18 h) induces time-dependent apoptosis in empty vector-transfected T-cell lymphoma CEM cells, whereas a significant delay in apoptosis is observed in CEM cells overexpressing bcl-2[2].
GD3 ganglioside (10-40 μM) induces cytochrome c release and caspase-9 activation in isolated mouse liver mitochondria[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GD3 Ganglioside Related Antibodies

Western Blot Analysis[2]

Cell Line: T cell lymphoma CEM cells
Concentration: 200 μM
Incubation Time: 6 h
Result: Induced degradation of pro-caspase 9 and appearance of the 32 kDa cleavage product in empty vector-transfected CEM cells.
Did not induce caspase 9 activation in bcl-2-overexpressing CEM cells.

Apoptosis Analysis[2]

Cell Line: T cell lymphoma CEM cells
Concentration: 200 μM
Incubation Time: up to 18 h
Result: Induced apoptosis in empty vector-transfected CEM cells, with hypodiploid nuclei increasing over time.
Substantially delayed apoptosis in bcl-2-overexpressing CEM cells.
CAS No.
SMILES

[GD3 Ganglioside]
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GD3 Ganglioside Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GD3 Ganglioside62010-37-1ApoptosisMitochondrial MetabolismCaspaseHEK-293 cellst cell lymphomaglioblastomarat liver mitochondriamitochondrial permeability transition pore complexmouse neural stem cellsHeLa cell nucleiBcl-2T cell lymphoma CEM cellscaspase-9Inhibitorinhibitorinhibit

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