GD3 Ganglioside
GD3 Ganglioside is an Apoptosis inducer and a biomarker for mouse neural stem cells. GD3 Ganglioside expresses in neural stem cells and the subventricular zone of the adult mouse brain. GD3 Ganglioside targets the mitochondrial permeability transition pore complex, induces pore opening, dissipates mitochondrial transmembrane potential, triggers Mitochondrial swelling, releases pro-apoptotic factors, and activates Caspase-9. GD3 Ganglioside is applicable to research related to glioblastoma.
For research use only. We do not sell to patients.
- CAS No.: 62010-37-1
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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Caspase-9 |
GD3 ganglioside (20 μM) induces rapid swelling of isolated rat liver mitochondria by opening the mitochondrial permeability transition pore complex[2].
GD3 ganglioside (200 μM; 6 h) induces caspase 9 activation in empty vector-transfected T-cell lymphoma CEM cells, and this effect is completely abrogated by forced expression of bcl-2[2].
GD3 ganglioside (200 μM; up to 18 h) induces time-dependent apoptosis in empty vector-transfected T-cell lymphoma CEM cells, whereas a significant delay in apoptosis is observed in CEM cells overexpressing bcl-2[2].
GD3 ganglioside (10-40 μM) induces cytochrome c release and caspase-9 activation in isolated mouse liver mitochondria[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T cell lymphoma CEM cells
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Concentration:200 μM
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Incubation Time:6 h
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Result:Induced degradation of pro-caspase 9 and appearance of the 32 kDa cleavage product in empty vector-transfected CEM cells.
Did not induce caspase 9 activation in bcl-2-overexpressing CEM cells.
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Cell Line:T cell lymphoma CEM cells
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Concentration:200 μM
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Incubation Time:up to 18 h
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Result:Induced apoptosis in empty vector-transfected CEM cells, with hypodiploid nuclei increasing over time.
Substantially delayed apoptosis in bcl-2-overexpressing CEM cells.
Chemical Information
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CAS No. 62010-37-1
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SMILES
[GD3 Ganglioside]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nakatani Y, et al. Characterization of GD3 ganglioside as a novel biomarker of mouse neural stem cells. Glycobiology. 2010;20(1):78-86. [Content Brief]
[2]. Rippo MR, et al. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. FASEB J. 2000;14(13):2047-2054. [Content Brief]
[3]. Malisan F, et al. Acetylation suppresses the proapoptotic activity of GD3 ganglioside. J Exp Med. 2002;196(12):1535-1541. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GD3 Ganglioside Related Classifications
HY-157343 Related Classifications
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