FAM3C - FAM3 metabolism regulating signaling molecule C Gene

Also Known as ILEI; GS3786

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10447

About FAM3C

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:121,348,878-121,396,396 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 3 paralogues. Ubiquitous expression in duodenum (RPKM 76.8), small intestine (RPKM 69.8) and 24 other tissues.

Summary

This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. [provided by RefSeq, Mar 2010]

FAM3C Products (2)

mRNA	Protein	Name
NM_001040020.2	NP_001035109.1	protein FAM3C precursor
NM_014888.3	NP_055703.1	protein FAM3C precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein FAM3C	family with sequence similarity 3 member C

FAM3C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FAM3C	Q92520	RELL2	Homo sapiens	Q8NC24	Y2H Array	32296183
Intra	FAM3C	Q92520	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TMEM248	Homo sapiens	Q9NWD8	Validated Y2H	32296183
Intra	FAM3C	Q92520	TMEM248	Homo sapiens	Q9NWD8	Y2H Array	32296183
Intra	FAM3C	Q92520	TMEM248	Homo sapiens	Q9NWD8	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	CYB5R3	Homo sapiens	P00387	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	CYB5R3	Homo sapiens	P00387	Y2H Array	32296183
Intra	FAM3C	Q92520	RMDN3	Homo sapiens	Q96TC7	Validated Y2H	32296183
Intra	FAM3C	Q92520	RMDN3	Homo sapiens	Q96TC7	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	RMDN3	Homo sapiens	Q96TC7	Y2H Array	32296183
Intra	FAM3C	Q92520	SORT1	Homo sapiens	Q99523	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	SORT1	Homo sapiens	Q99523	Validated Y2H	32296183
Intra	FAM3C	Q92520	SORT1	Homo sapiens	Q99523	Y2H Array	32296183
Intra	FAM3C	Q92520	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	FAM3C	Q92520	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	FAM3C	Q92520	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	FAM3C	Q92520	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	FAM3C	Q92520	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	FAM3C	Q92520	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	FAM3C	Q92520	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	FAM3C	Q92520	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	FAM3C	Q92520	CLEC17A	Homo sapiens	Q6ZS10	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	CLEC17A	Homo sapiens	Q6ZS10	Y2H Array	32296183
Intra	FAM3C	Q92520	KCNA2	Homo sapiens	P16389-2	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	KCNA2	Homo sapiens	P16389-2	Y2H Array	32296183
Intra	FAM3C	Q92520	SPINT1	Homo sapiens	O43278-2	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	SPINT1	Homo sapiens	O43278-2	Y2H Array	32296183
Intra	FAM3C	Q92520	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Array	32296183
Intra	FAM3C	Q92520	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	FAM3C	Q92520	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	FAM3C	Q92520	AQP2	Homo sapiens	P41181	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	AQP2	Homo sapiens	P41181	Y2H Array	32296183
Intra	FAM3C	Q92520	CLEC4E	Homo sapiens	Q9ULY5	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	CLEC4E	Homo sapiens	Q9ULY5	Validated Y2H	32296183
Intra	FAM3C	Q92520	CLEC4E	Homo sapiens	Q9ULY5	Y2H Array	32296183
Intra	FAM3C	Q92520	TMEM71	Homo sapiens	Q6P5X7-2	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TMEM71	Homo sapiens	Q6P5X7-2	Y2H Array	32296183
Intra	FAM3C	Q92520	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	FAM3C	Q92520	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	FAM3C	Q92520	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TM4SF18	Homo sapiens	Q96CE8	Validated Y2H	32296183
Intra	FAM3C	Q92520	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	FAM3C	Q92520	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	FAM3C	Q92520	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	FAM3C	Q92520	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	FAM3C	Q92520	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	FAM3C	Q92520	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	FAM3C	Q92520	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	FAM3C	Q92520	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	FAM3C	Q92520	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	NECTIN1	Homo sapiens	Q15223	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	NECTIN1	Homo sapiens	Q15223	Y2H Array	32296183
Intra	FAM3C	Q92520	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	FAM3C	Q92520	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	FAM3C	Q92520	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	FAM3C	Q92520	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	FAM3C	Q92520	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	FAM3C	Q92520	TEX29	Homo sapiens	Q8N6K0	Y2H Array	32296183
Intra	FAM3C	Q92520	TEX29	Homo sapiens	Q8N6K0	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	FAM3C	Q92520	RNASEH1	Homo sapiens	O60930	Y2H Array	32296183
Intra	FAM3C	Q92520	RNASEH1	Homo sapiens	O60930	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	FAM3C	Q92520	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	FCGRT	Homo sapiens	P55899	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	FCGRT	Homo sapiens	P55899	Y2H Array	32296183
Intra	FAM3C	Q92520	HHLA2	Homo sapiens	Q9UM44	Y2H Array	32296183
Intra	FAM3C	Q92520	HHLA2	Homo sapiens	Q9UM44	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	HHLA2	Homo sapiens	Q9UM44	Validated Y2H	32296183
Intra	FAM3C	Q92520	GGT6	Homo sapiens	Q6P531	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	GGT6	Homo sapiens	Q6P531	Y2H Array	32296183
Intra	FAM3C	Q92520	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183
Intra	FAM3C	Q92520	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	FAM3C	Q92520	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	FAM3C	Q92520	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	FAM3C	Q92520	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	FAM3C	Q92520	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	FAM3C	Q92520	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TMEM45B	Homo sapiens	Q96B21	Validated Y2H	32296183
Intra	FAM3C	Q92520	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	FAM3C	Q92520	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	FAM3C	Q92520	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	FAM3C	Q92520	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	25416956
Intra	FAM3C	Q92520	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	31515488
Intra	FAM3C	Q92520	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	FAM3C	Q92520	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	FAM3C	Q92520	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	FAM3C	Q92520	CXADR	Homo sapiens	P78310	Y2H Array	32296183
Intra	FAM3C	Q92520	CXADR	Homo sapiens	P78310	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	BNIP3	Homo sapiens	Q12983	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	BNIP3	Homo sapiens	Q12983	Y2H Array	32296183
Intra	FAM3C	Q92520	BNIP2	Homo sapiens	Q12982	Y2H Array	32296183
Intra	FAM3C	Q92520	BNIP2	Homo sapiens	Q12982	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	FAM3C	Q92520	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	FAM3C	Q92520	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	IL7R	Homo sapiens	P16871	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	IL7R	Homo sapiens	P16871	Y2H Array	32296183
Intra	FAM3C	Q92520	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	FAM3C	Q92520	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FAM3C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70885	FAM3C Protein, Human (HEK293, His)	Q92520 (Q25-D227)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 17	DFNB17 Autosomal Recessive Nonsyndromic Deafness 17 Autosomal Recessive Deafness 17
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04713	FAM3C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18277	Fam3c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24755	Fam3c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FAM3C	RGD	RGD:735193
Mus musculus	FAM3C	MGD	MGI:107892
Macaca mulatta	FAM3C	VGNC	VGNC:72296
Bos taurus	FAM3C	VGNC	VGNC:28811
Canis familiaris	FAM3C	VGNC	VGNC:40679
Felis catus	FAM3C	VGNC	VGNC:62112
Others	FAM3C	NCBI