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Rhoa - ras homolog family member A Gene

Also Known as Arha; Arha2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 117273

Summary

Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of cellular protein metabolic process; and regulation of neuron projection development. Acts upstream of or within negative regulation of vascular associated smooth muscle cell migration and negative regulation of vascular associated smooth muscle cell proliferation. Located in axon; cytosol; and membrane. Used to study membranous glomerulonephritis. Biomarker of asthma; fetal alcohol syndrome; hypertension; obesity; and pulmonary hypertension. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (Ras homolog family member A). [provided by Alliance of Genome Resources, Apr 2022]

Rhoa Products (1)

mRNA	Protein	Name
NM_057132.3	NP_476473.1	transforming protein RhoA

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GDP binding	IDA IDA: Inferred from direct assay	20472934	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	20472934	RGD
enables GTPase activity	IDA IDA: Inferred from direct assay	21440892	RGD
enables Rho GDP-dissociation inhibitor binding	IPI IPI: Inferred from physical interaction	17379756	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17620967	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11696353	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in GTP metabolic process	IDA IDA: Inferred from direct assay	21440892	RGD
acts upstream of or within Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	29453251	RGD
involved in microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	20858895	RGD
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	17615156	RGD
involved in negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	14517206	RGD
involved in negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	14662747	RGD
involved in negative regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	27893610	RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	29453251	RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	29453251	RGD
involved in neuron projection morphogenesis	IEP IEP: Inferred from expression pattern	17109064	RGD
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	17369454	RGD
involved in positive regulation of cell adhesion	IEP IEP: Inferred from expression pattern	17488779	RGD
involved in positive regulation of cell growth	IEP IEP: Inferred from expression pattern	17562852	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	17537920	RGD
involved in positive regulation of cell migration	IEP IEP: Inferred from expression pattern	17488779	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17425560	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17425560	RGD
involved in positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	17379756	RGD
involved in positive regulation of translation	IEP IEP: Inferred from expression pattern	17562852	RGD
involved in positive regulation of vasoconstriction	IEP IEP: Inferred from expression pattern	17468135	RGD
involved in regulation of actin polymerization or depolymerization	IEP IEP: Inferred from expression pattern	17562852	RGD
involved in regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	17558400	RGD
involved in regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	17670984	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17515837	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17109064	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	18391481	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	18356410	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16205723	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17456553	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	17492663	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17596891	RGD
involved in stress-activated protein kinase signaling cascade	IMP IMP: Inferred from mutant phenotype	17369826	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	18554585	RGD
located in cytosol	IDA IDA: Inferred from direct assay	21440892	RGD
located in dendrite	IDA IDA: Inferred from direct assay	26738857	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	26738857	RGD
located in membrane	IDA IDA: Inferred from direct assay	21440892	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	26738857	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transforming protein RhoA	plysia ras-related homolog A2 ras homolog gene family, member A

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10341	Fasudil Hydrochloride	99.97%	Yes
HY-10341A	Fasudil	99.98%	Yes
HY-109523	Cerivastatin sodium	99.89%	Unkown
HY-10341C	Fasudil dihydrochloride	99.98%	Yes
HY-10341B	Fasudil hydrochloride semihydrate	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-I0400	N-Acetylneuraminic acid		99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12646	Rhosin hydrochloride		99.94%	Unkown
HY-108566	U-46619	Agonist	99.61%	Unkown
HY-16563	Narciclasine	Activator	99.88%	Unkown
HY-12646A	Rhosin		98.74%	Unkown
HY-108361	CCG-203971	Inhibitor	99.89%	Unkown
HY-15477	YS-49		99.98%	Unkown
HY-12649	Y16	Inhibitor	98.12%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-135457	JMS-053	Inhibitor	98.0%	Unkown
HY-113849	MLS-573151	Inhibitor	99.66%	Unkown
HY-N0168A	(Rac)-Hesperetin	Inhibitor	99.28%	Unkown
HY-117548	UNC1062		98.92%	Unkown
HY-15477A	YS-49 monohydrate		99.56%	Unkown
HY-145915A	(E/Z)-ZINC09659342	Inhibitor	99.71%	Unkown
HY-168596	RhoA-ROCK-IN-1		98.40%	Unkown
HY-121667	Scaff10-8	Inhibitor	99.11%	Unkown
HY-RS11945	RHOA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N0168AS1	(Rac)-Hesperetin-13C,d3	Inhibitor	99.3%	Unkown
HY-139061	Palmitoyl 3-carbacyclic phosphatidic acid	Inhibitor	99.9%	Unkown
HY-P2325	Exoenzyme C3, clostridium botulinum	Inhibitor	/	Unkown
HY-N0168AS	(Rac)-Hesperetin-d3	Inhibitor	/	Unkown
HY-104023	ZK-Thiazolidinone	Inhibitor	/	Unkown
HY-109523S	Cerivastatin-d3 sodium		/	Unkown
HY-123958	SB772077B	Inhibitor	/	Unkown
HY-129458	Cerivastatin		/	Unkown
HY-145915	ZINC09659342	Inhibitor	/	Unkown
HY-150187	20:4 Lyso PI		/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	Unkown
HY-180371	NF-115	Inducer	/	Unkown
HY-10341D	Fasudil mesylate		/	Unkown
HY-158652	(R)-CCG-1423	Inhibitor	/	Unkown
HY-N14739	Dykellic acid	Inhibitor	/	Unkown
HY-RS17004	Rhoa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23447	Rhoa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990805	Anti-Human/Mouse GRP78 Antibody (C38)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rhoa	NCBI	NCBI:387