Apc - APC, WNT signaling pathway regulator Gene

Also Known as CC1; Min; mAPC

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11789

About Apc

Chromosome 18: 34,353,977-34,455,605 forward strand.GRCm39:CM001011.3

This gene has 9 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 121 phenotypes. Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues.

Summary

Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in Insulin Receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule Cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system Cancer (multiple); and reproductive organ Cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial Cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]

Apc Products (17)

mRNA Protein Name
NM_001402740.1 NP_001389669.1 adenomatous polyposis coli protein isoform 10
NM_001402738.1 NP_001389667.1 adenomatous polyposis coli protein isoform 8
NM_001402729.1 NP_001389658.1 adenomatous polyposis coli protein isoform 2
NM_001402736.1 NP_001389665.1 adenomatous polyposis coli protein isoform 7
NM_001402732.1 NP_001389661.1 adenomatous polyposis coli protein isoform 4
NM_001360979.1 NP_001347908.1 adenomatous polyposis coli protein isoform 2
NM_001402727.1 NP_001389656.1 adenomatous polyposis coli protein isoform 1
NM_001402737.1 NP_001389666.1 adenomatous polyposis coli protein isoform 7
NM_001402731.1 NP_001389660.1 adenomatous polyposis coli protein isoform 3
NM_001402735.1 NP_001389664.1 adenomatous polyposis coli protein isoform 6
NM_001360980.1 NP_001347909.1 adenomatous polyposis coli protein isoform 1
NM_007462.4 NP_031488.2 adenomatous polyposis coli protein isoform 3
NM_001402728.1 NP_001389657.1 adenomatous polyposis coli protein isoform 2
NM_001402734.1 NP_001389663.1 adenomatous polyposis coli protein isoform 6
NM_001402733.1 NP_001389662.1 adenomatous polyposis coli protein isoform 5
NM_001402739.1 NP_001389668.1 adenomatous polyposis coli protein isoform 9
NM_001402730.1 NP_001389659.1 adenomatous polyposis coli protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
10346819 MGI
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
12874278 MGI
enables dynein complex binding IPI
IPI: Inferred from physical interaction
28057765 MGI
enables microtubule plus-end binding IDA
IDA: Inferred from direct assay
18716223 MGI
enables protease binding IPI
IPI: Inferred from physical interaction
18281465 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15327768 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
28057765 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of MAPK cascade IGI
IGI: Inferred from genetic interaction
16478791 MGI
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16478791 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
16025118 MGI
acts upstream of or within Wnt signaling pathway IDA
IDA: Inferred from direct assay
10346819 MGI
acts upstream of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18644872 MGI
acts upstream of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
11756652 MGI
acts upstream of or within Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
12645927 MGI
acts upstream of acinar cell proliferation IGI
IGI: Inferred from genetic interaction
17596282 MGI
acts upstream of acinar cell proliferation IMP
IMP: Inferred from mutant phenotype
17596282 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
12645927 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
11756652 MGI
acts upstream of or within axis specification IMP
IMP: Inferred from mutant phenotype
12645927 MGI
acts upstream of or within axonogenesis IGI
IGI: Inferred from genetic interaction
18716223 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
15207235 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
11756652 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
16887818 MGI
acts upstream of or within canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
17377531 MGI
acts upstream of or within canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
17377531 MGI
acts upstream of cell adhesion IMP
IMP: Inferred from mutant phenotype
16368433 MGI
acts upstream of cell division IMP
IMP: Inferred from mutant phenotype
16950562 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
15198980 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
8945508 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
7954428 MGI
acts upstream of or within chromosome organization IGI
IGI: Inferred from genetic interaction
17200209 MGI
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
17200209 MGI
acts upstream of or within cytoplasmic microtubule organization IGI
IGI: Inferred from genetic interaction
18716223 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
12645927 MGI
acts upstream of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
9159163 MGI
acts upstream of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
9060821 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16950562 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
14758356 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10535960 MGI
acts upstream of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
17363566 MGI
acts upstream of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
17227893 MGI
acts upstream of fibroblast migration IMP
IMP: Inferred from mutant phenotype
17192415 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
17002498 MGI
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28057765 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
15550389 MGI
acts upstream of or within metaphase/anaphase transition of mitotic cell cycle IGI
IGI: Inferred from genetic interaction
15767571 MGI
acts upstream of or within metaphase/anaphase transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15767571 MGI
acts upstream of microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
16525027 MGI
acts upstream of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
16525027 MGI
acts upstream of or within mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
17570218 MGI
acts upstream of or within muscle cell cellular homeostasis IGI
IGI: Inferred from genetic interaction
18056981 MGI
acts upstream of or within negative regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
16478791 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16478791 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18644872 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
11756652 MGI
acts upstream of or within negative regulation of acinar cell proliferation IGI
IGI: Inferred from genetic interaction
17596282 MGI
acts upstream of or within negative regulation of acinar cell proliferation IMP
IMP: Inferred from mutant phenotype
17596282 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11756652 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
11756652 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
8945508 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
7954428 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
9159163 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
9060821 MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16950562 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
9037065 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10535960 MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
17363566 MGI
acts upstream of or within negative regulation of microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
16525027 MGI
acts upstream of or within negative regulation of odontogenesis IMP
IMP: Inferred from mutant phenotype
17002498 MGI
acts upstream of or within nitrogen cycle metabolic process IMP
IMP: Inferred from mutant phenotype
16740478 MGI
acts upstream of odontogenesis IMP
IMP: Inferred from mutant phenotype
17002498 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
16740478 MGI
acts upstream of or within positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
16368433 MGI
acts upstream of or within positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
15198980 MGI
acts upstream of or within positive regulation of cell division IMP
IMP: Inferred from mutant phenotype
16950562 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26948948 MGI
acts upstream of or within positive regulation of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
17227893 MGI
acts upstream of or within positive regulation of fibroblast migration IMP
IMP: Inferred from mutant phenotype
17192415 MGI
acts upstream of or within positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
16525027 MGI
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
16478791 MGI
involved in positive regulation of protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
28057765 MGI
acts upstream of protein catabolic process IMP
IMP: Inferred from mutant phenotype
16478791 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: Inferred from mutant phenotype
16887818 MGI
acts upstream of or within regulation of attachment of spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
17227893 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
8988060 MGI
acts upstream of or within regulation of cell differentiation IGI
IGI: Inferred from genetic interaction
17377531 MGI
acts upstream of or within regulation of cell migration IGI
IGI: Inferred from genetic interaction
17377531 MGI
acts upstream of or within regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
9771477 MGI
acts upstream of or within regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
9371501 MGI
acts upstream of or within regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15802266 MGI
acts upstream of or within regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
15802266 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
10982921 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
9453487 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: Inferred from genetic interaction
1541640 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
1541640 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
18725524 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
16025118 MGI
Cellular Component GO Annotation Evidence References Source
part of Scrib-APC-beta-catenin complex IDA
IDA: Inferred from direct assay
16611247 MGI
located in axon IDA
IDA: Inferred from direct assay
15207235 MGI
located in axonal growth cone IDA
IDA: Inferred from direct assay
18716223 MGI
located in cell projection IDA
IDA: Inferred from direct assay
16525027 MGI
located in cell projection membrane IDA
IDA: Inferred from direct assay
16621792 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8670282 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
31746486 MGI
located in growth cone IDA
IDA: Inferred from direct assay
15207235 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
16525027 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10346819 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
31746486 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Apc Protein Structure

APC_N_CC

APC_N_CC: pfam16689 (3 - 54)

Suppressor_APC

Suppressor_APC: pfam11414 (124 - 204)

ARM

ARM: smart00185 (337 - 389)

APC_rep

APC_rep: pfam18797 (390 - 463)

ARM

ARM: smart00185 (456 - 507)

ARM

ARM: sd00043 (462 - 505)

ARM

ARM: smart00185 (509 - 550)

ARM

ARM: sd00043 (513 - 550)

ARM

ARM: sd00043 (557 - 592)

ARM

ARM: sd00043 (600 - 641)

ARM

ARM: smart00185 (646 - 686)

ARM

ARM: sd00043 (650 - 684)

Arm

Arm: pfam00514 (688 - 728)

ARM

ARM: sd00043 (692 - 728)

Arm_APC_u3

Arm_APC_u3: pfam16629 (729 - 1016)

APC_u5

APC_u5: pfam16630 (1033 - 1132)

APC_r

APC_r: pfam05923 (1254 - 1271)

APC_u9

APC_u9: pfam16633 (1280 - 1366)

APC_r

APC_r: pfam05923 (1634 - 1657)

APC_u13

APC_u13: pfam16634 (1659 - 1712)

SAMP

SAMP: pfam05924 (1713 - 1734)

APC_u14

APC_u14: pfam16635 (1743 - 1836)

APC_u15

APC_u15: pfam16636 (1870 - 1944)

SAMP

SAMP: pfam05924 (2031 - 2050)

APC_basic

APC_basic: pfam05956 (2222 - 2567)

EB1_binding

EB1_binding: cl05480 (2669 - 2841)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2842 a.a.
Protein Preferred Names Protein Names

adenomatous polyposis coli protein

  • adenomatosis polyposis coli

  • multiple intestinal neoplasia

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112968 Human protein C / Unkown

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124955 proTAME Inhibitor 98.20% Unkown
HY-110287 Apcin Inhibitor 99.62% Unkown
HY-130257 CP5V Degrader 99.31% Unkown
HY-13255 TAME Inhibitor 99.51% Unkown
HY-130841 Apcin-A Inhibitor 98.0% Unkown
HY-P1918 Activated Protein C (390-404), human 98.74% Unkown
HY-13255A TAME hydrochloride Inhibitor 98.14% Unkown
HY-122142A Pyr-​Pro-​Arg-​pNA (hydrochloride) Substrate 99.24% Unkown
HY-182052 Ferroptosis inducer-16 Inhibitor / Unkown
HY-126016 MAI-400 Inhibitor / Unkown
HY-P1918A Activated Protein C (390-404), human TFA / Unkown
HY-116473 CFM-1 Antagonist / Unkown
HY-179012 CDC20/HSP90-IN-1 Inhibitor / Unkown
HY-172401 CDC20-IN-2 Inhibitor / Unkown
HY-112968A Bovine Protein C / Unkown
HY-122142 Pyr-​Pro-​Arg-​pNA Substrate / Unkown
HY-W614725 Apcin-A monohydrochloride Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992193 Anti-B7-H7 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apc NCBI NCBI:324