Epha2 - Eph receptor A2 Gene

Also Known as Eck; Myk2; Sek2; Sek-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13836

Summary

Predicted to enable growth factor binding activity and transmembrane-ephrin receptor activity. Involved in several processes, including animal organ development; osteoblast differentiation; and regulation of blood vessel endothelial cell migration. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; endometrium; and limb. Used to study cataract 6 multiple types. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EphA2 (EPH receptor A2). [provided by Alliance of Genome Resources, Apr 2022]

Epha2 Products (1)

mRNA Protein Name
NM_010139.3 NP_034269.2 ephrin type-A receptor 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16782872 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axial mesoderm formation IMP
IMP: Inferred from mutant phenotype
11287184 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
11287184 MGI
acts upstream of or within blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
19443703 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
19443703 MGI
involved in bone remodeling IMP
IMP: Inferred from mutant phenotype
19299512 MGI
involved in branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
19321667 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
19443703 MGI
acts upstream of or within ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
14988728 MGI
involved in ephrin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18948590 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
19443703 MGI
involved in lens fiber cell morphogenesis IDA
IDA: Inferred from direct assay
18948590 MGI
involved in mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19321667 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
19443703 MGI
acts upstream of or within negative regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
19443703 MGI
acts upstream of or within negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
19443703 MGI
acts upstream of or within negative regulation of lymphangiogenesis IMP
IMP: Inferred from mutant phenotype
19443703 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
11287184 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
15145949 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
15145949 MGI
acts upstream of or within notochord cell development IMP
IMP: Inferred from mutant phenotype
11287184 MGI
acts upstream of or within notochord formation IGI
IGI: Inferred from genetic interaction
11287184 MGI
acts upstream of or within notochord formation IMP
IMP: Inferred from mutant phenotype
11287184 MGI
acts upstream of or within notochord morphogenesis IMP
IMP: Inferred from mutant phenotype
11287184 MGI
involved in osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
19299512 MGI
involved in osteoclast differentiation IDA
IDA: Inferred from direct assay
19299512 MGI
acts upstream of or within pericyte cell differentiation IMP
IMP: Inferred from mutant phenotype
19443703 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
11287184 MGI
involved in regulation of angiogenesis IDA
IDA: Inferred from direct assay
16782872 MGI
involved in regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
16782872 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
11287184 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
11287184 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
27733379 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin type-A receptor 2

  • epithelial cell kinase

  • tyrosine-protein kinase receptor ECK

  • tyrosine-protein kinase receptor MPK-5

  • tyrosine-protein kinase receptor SEK-2

Epha2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Epha2 Q03145 Epha4 Mus musculus Q03137
Protein Kinase Assay
16977320
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Epha2 Proteins

Cat. No. Product Name Accession Purity
HY-P75240 EphA2 Protein, Mouse (HEK293, His) Q03145 (K26-N535) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13258A NVP-BHG712 Inhibitor 99.71% Unkown
HY-133178 Urolithin D 99.72% Unkown
HY-13258 NVP-BHG712 isomer 99.32% Unkown
HY-123607 UniPR129 Antagonist 99.23% Unkown
HY-P3717 Targefrin 99.80% Unkown
HY-124813 PDZ1i Inhibitor 99.29% Unkown
HY-169849 EphA2 antagonist 1 Inhibitor 97.4% Unkown
HY-147637 EphA2 agonist 1 Agonist 98.57% Unkown
HY-P10412 A11 Inhibitor 98.49% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-157019 UniPR1447 Antagonist 99.46% Unkown
HY-P10579 123B9 Agonist 99.67% Unkown
HY-W078239 EPHA4 antagonist-1 Antagonist 95.61% Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-133178R Urolithin D (Standard) / Unkown
HY-146141 EphA2 agonist 2 Agonist 98.64% Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-157020 UniPR1449 Antagonist / Unkown
HY-159174 EPHA2/A4/GAK-IN-1 Inhibitor / Unkown
HY-161170 Antimalarial agent 36 Inhibitor / Unkown
HY-163835 UniPR1454 Antagonist / Unkown
HY-178721 Lithocholic amide-C2-N(didecane) Inhibitor / Unkown
HY-18692 Multi-kinase-IN-12 Inhibitor / Unkown
HY-P10412A A11 acetate Inhibitor 98.48% Unkown
HY-P11015 (123B9)2-Motif Agonist / Unkown
HY-P11018 (123B9)2-L2-PTX Agonist / Unkown
HY-RS04426 EPHA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-171175 UniPR500 Antagonist / Unkown
HY-RS16753 Epha2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23192 Epha2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990627 Anti-EphA2 Antibody (1C1) Inhibitor 99.9% Unkown
HY-P991577 DS-8895 Inhibitor 97.19% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epha2 NCBI NCBI:1969