2. Gene
  3. Met - met proto-oncogene Gene

Met - met proto-oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HGF; HGFR; Par4; c-Met

Gene ID: 17295 | Gene type: protein coding

About Met

Chromosome 6: 17,463,799-17,573,979 forward strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 207 orthologues, 53 paralogues and is associated with 62 phenotypes. Broad expression in kidney adult (RPKM 1.5), bladder adult (RPKM 6.1) and 21 other tissues.

Summary

Enables hepatocyte growth factor-activated receptor activity. Involved in cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and positive chemotaxis. Acts upstream of or within several processes, including animal organ development; regulation of cellular response to stress; and regulation of cytokine production. Located in membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Used to study Gilles de la Tourette syndrome; autism spectrum disorder; breast cancer; and gestational diabetes. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Met Products(4)

mRNA Protein Name
NM_001410124.1 NP_001397053.1 hepatocyte growth factor receptor isoform b precursor
NM_001410123.1 NP_001397052.1 hepatocyte growth factor receptor isoform a precursor
NM_008591.3 NP_032617.2 hepatocyte growth factor receptor isoform a precursor
NM_001410120.1 NP_001397049.1 hepatocyte growth factor receptor isoform a precursor

Met Protein Structure

Sema

Sema: cl15693 (24 - 514)

PSI

PSI: smart00423 (517 - 559)

IPT_plexin_repeat1

IPT_plexin_repeat1: cd01180 (561 - 654)

IPT_plexin_repeat2

IPT_plexin_repeat2: cd01179 (655 - 738)

IPT

IPT: cl15674 (740 - 835)

IPT_PCSR

IPT_PCSR: cd00603 (837 - 916)

PTKc_Met_Ron

PTKc_Met_Ron: cd05058 (1079 - 1340)

  • 0
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  • 1379 a.a.
Protein Preferred Names Protein Names

hepatocyte growth factor receptor

HGF receptor

HGF/SF receptor

SF receptor

met proto-oncogene tyrosine kinase

proto-oncogene c-Met

scatter factor receptor

tyrosine-protein kinase Met

Recombinant Met Proteins

Cat. No. Product Name Accession Purity
HY-P72940 HGFR Protein, Mouse (HEK293, Fc) P16056 (E25-N929) ≥95%
HY-P72941 HGFR Protein, Mouse (HEK293, His) EDL13881.1(E25-N929) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13016 Cabozantinib Inhibitor 99.96% Yes
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12035 AMG-208 Inhibitor 99.86% Phase 2
HY-16446 SAR125844 Inhibitor 98.11% Phase 2
HY-50683 JNJ-38877605 Inhibitor 99.95% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99455 Bafisontamab Inhibitor 96.00% Phase 3
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114357A DS-1205b free base Inhibitor 99.92% Unkown
HY-161372 PARP1/c-Met-IN-1 Inhibitor / Unkown
HY-157387 c-Met-IN-22 Inhibitor / Unkown
HY-120908 c-Met-IN-16 Inhibitor / Unkown
HY-149675 VEGFR-2/c-Met-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Met NCBI NCBI:4233
Canis familiaris Met NCBI NCBI:403438
Macaca fascicularis Met NCBI NCBI:102123512
Susscrofa domestica Met NCBI
Rattus norvegicus Met NCBI NCBI:24553
Macaca mulatta Met NCBI NCBI:704562