Met - met proto-oncogene Gene

Also Known as HGF; HGFR; Par4; c-Met

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17295

About Met

Chromosome 6: 17,463,799-17,573,979 forward strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 207 orthologues, 53 paralogues and is associated with 62 phenotypes. Broad expression in kidney adult (RPKM 1.5), bladder adult (RPKM 6.1) and 21 other tissues.

Summary

Enables hepatocyte growth factor-activated receptor activity. Involved in cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and positive chemotaxis. Acts upstream of or within several processes, including animal organ development; regulation of cellular response to stress; and regulation of cytokine production. Located in membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Used to study Gilles de la Tourette syndrome; autism spectrum disorder; breast cancer; and gestational diabetes. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Met Products (4)

mRNA Protein Name
NM_001410124.1 NP_001397053.1 hepatocyte growth factor receptor isoform b precursor
NM_001410123.1 NP_001397052.1 hepatocyte growth factor receptor isoform a precursor
NM_008591.3 NP_032617.2 hepatocyte growth factor receptor isoform a precursor
NM_001410120.1 NP_001397049.1 hepatocyte growth factor receptor isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hepatocyte growth factor receptor activity IDA
IDA: Inferred from direct assay
15314156 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18585357 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
7651534 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of D-glucose transmembrane transport IMP
IMP: Inferred from mutant phenotype
16049329 MGI
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
12397180 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
12397180 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
23994610 MGI
acts upstream of or within cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
23994610 MGI
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
21490227 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
16049329 MGI
involved in excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
21490227 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
16049329 MGI
acts upstream of or within hepatocyte growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
15314156 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
7651534 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
21490227 MGI
acts upstream of or within muscle cell migration IMP
IMP: Inferred from mutant phenotype
7651534 MGI
acts upstream of or within muscle organ development IGI
IGI: Inferred from genetic interaction
15376315 MGI
acts upstream of or within muscle organ development IMP
IMP: Inferred from mutant phenotype
15376315 MGI
acts upstream of or within myoblast proliferation IMP
IMP: Inferred from mutant phenotype
11061428 MGI
acts upstream of or within myotube differentiation IMP
IMP: Inferred from mutant phenotype
7651534 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23994610 MGI
acts upstream of or within negative regulation of transforming growth factor beta production IMP
IMP: Inferred from mutant phenotype
23994610 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
7651534 MGI
involved in positive chemotaxis IMP
IMP: Inferred from mutant phenotype
15218527 MGI
acts upstream of or within positive regulation of D-glucose transmembrane transport IMP
IMP: Inferred from mutant phenotype
16049329 MGI
acts upstream of or within positive regulation of MAPK cascade IPI
IPI: Inferred from physical interaction
15314156 MGI
acts upstream of or within positive regulation of p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
23994610 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
15314156 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
23994610 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IMP
IMP: Inferred from mutant phenotype
14517989 MGI
acts upstream of or within regulation of cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
23994610 MGI
acts upstream of or within regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
21072211 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
15218527 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
7651534 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
7565774 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Met Protein Structure

Sema

Sema: cl15693 (24 - 514)

PSI

PSI: smart00423 (517 - 559)

IPT_plexin_repeat1

IPT_plexin_repeat1: cd01180 (561 - 654)

IPT_plexin_repeat2

IPT_plexin_repeat2: cd01179 (655 - 738)

IPT

IPT: cl15674 (740 - 835)

IPT_PCSR

IPT_PCSR: cd00603 (837 - 916)

PTKc_Met_Ron

PTKc_Met_Ron: cd05058 (1079 - 1340)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1379 a.a.
Protein Preferred Names Protein Names

hepatocyte growth factor receptor

  • HGF receptor

  • HGF/SF receptor

  • SF receptor

  • met proto-oncogene tyrosine kinase

  • proto-oncogene c-Met

  • scatter factor receptor

  • tyrosine-protein kinase Met

Recombinant Met Proteins

Cat. No. Product Name Accession Purity
HY-P72940 HGFR Protein, Mouse (HEK293, Fc) NP_032617.2 (E25-N929) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72941 HGFR Protein, Mouse (HEK293, His) EDL13881.1 (E25-N929) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13016 Cabozantinib Inhibitor 99.97% Yes
HY-13404 Capmatinib Inhibitor 99.71% Yes
HY-14721 Tepotinib Inhibitor 99.94% Yes

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16446 SAR125844 Inhibitor 98.17% Phase 2
HY-12035 AMG-208 Inhibitor 99.86% Phase 2
HY-50683 JNJ-38877605 Inhibitor 99.95% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99455 Bafisontamab Inhibitor 99.9% Phase 3

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12017 PF-04217903 Inhibitor 99.85% Unkown
HY-123961 SJF-8240 Degrader 99.33% Unkown
HY-168135 PROTAC c-Met degrader-1 Degrader 98.48% Unkown
HY-12017A PF-04217903 mesylate Inhibitor 99.82% Unkown
HY-114357A DS-1205b free base Inhibitor 99.92% Unkown
HY-157551 JNK-IN-16 Inhibitor 99.82% Unkown
HY-12017B PF-04217903 phenolsulfonate Inhibitor / Unkown
HY-13752 STA-1474 Inhibitor / Unkown
HY-183579 c-Met-IN-27 Inhibitor / Unkown
HY-162803 c-Met-IN-24 Inhibitor / Unkown
HY-D3352 EMI-137 / Unkown
HY-179098 Multi-target kinase-IN-8 Inhibitor / Unkown
HY-175321 PROTAC c-Met degrader-6 Degrader / Unkown
HY-161372 PARP1/c-Met-IN-1 Inhibitor / Unkown
HY-184305 c-Met-IN-30 Inhibitor / Unkown
HY-157387 c-Met-IN-22 Inhibitor / Unkown
HY-168910 PROTAC c-Met degrader-3 Degrader / Unkown
HY-171824 PROTAC c-Met Degrader-4 Degrader / Unkown
HY-181928 PARP1/c-Met-IN-3 Inhibitor / Unkown
HY-178348 PARP1/c-Met-IN-2 Inhibitor / Unkown
HY-123237 KRC-108 Inhibitor / Unkown
HY-175848 NSC 850745 Inhibitor / Unkown
HY-120908 c-Met-IN-16 Inhibitor / Unkown
HY-45124 3-Fluoro-desmethyl-cabozantinib / Unkown
HY-149675 VEGFR-2/c-Met-IN-2 Inhibitor / Unkown
HY-181776 c-Met-IN-31 Inhibitor / Unkown
HY-179034 CAIX/XII-IN-16 Inhibitor / Unkown
HY-177134 Taligantinib Inhibitor / Unkown
HY-W425461 c-Met ligand-1 Ligand / Unkown
HY-12017C PF-04217903 phosphate Inhibitor / Unkown
HY-13752B STA-1474 sodium Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992481 VERT-002 Degrader / Unkown
HY-P991565 CE-355621 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Met NCBI NCBI:4233