Ros1 - Ros1 proto-oncogene Gene

Also Known as Ros-1; c-ros

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19886

About Ros1

Chromosome 10: 51,921,817-52,071,340 reverse strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 125 orthologues, 53 paralogues and is associated with 11 phenotypes. Restricted expression toward genital fat pad adult (RPKM 7.5).

Summary

Enables protein Phosphatase binding activity. Involved in several processes, including columnar/cuboidal epithelial cell development; regulation of ERK1 and ERK2 cascade; and spermatogenesis. Acts upstream of or within several processes, including negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; and regulation of phosphate transport. Located in cell surface and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; intestine; lung; stomach; and trunk. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ros1 Products (1)

mRNA Protein Name
NM_011282.2 NP_035412.2 proto-oncogene tyrosine-protein kinase ROS precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
11266449 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
12661006 MGI
Biological Process GO Annotation Evidence References Source
involved in cell differentiation IDA
IDA: Inferred from direct assay
11266449 MGI
involved in columnar/cuboidal epithelial cell development IMP
IMP: Inferred from mutant phenotype
8675006 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
12399522 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
12773415 MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation IDA
IDA: Inferred from direct assay
7970722 MGI
involved in peptidyl-tyrosine autophosphorylation IDA
IDA: Inferred from direct assay
12661006 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11266449 MGI
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
11266449 MGI
acts upstream of or within regulation of phosphate transport IMP
IMP: Inferred from mutant phenotype
12773415 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
7854358 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
12773415 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
8675006 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
7970722 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
7970722 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ros1 Protein Structure

FN3

FN3: smart00060 (111 - 178)

FN3

FN3: cd00063 (206 - 290)

FN3

FN3: cd00063 (567 - 663)

FN3

FN3: cd00063 (1036 - 1142)

FN3

FN3: cd00063 (1550 - 1629)

FN3

FN3: cd00063 (1649 - 1740)

FN3

FN3: cd00063 (1745 - 1838)

PTKc_c-ros

PTKc_c-ros: cd05044 (1947 - 2208)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2340 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase ROS

  • c-Ros receptor tyrosine kinase

  • c-ros-1

  • proto-oncogene c-Ros

  • proto-oncogene c-Ros-1

  • receptor tyrosine kinase c-ros oncogene 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50878 Crizotinib Inhibitor 99.97% Yes
HY-12215 Lorlatinib 99.99% Yes
HY-W015913 Pyruvic acid sodium Inhibitor 99.86% Yes
HY-12678 Entrectinib 99.26% Yes
HY-103022 Repotrectinib Inhibitor 99.95% Unkown
HY-131003 Taletrectinib Inhibitor 99.63% Unkown
HY-50878A Crizotinib hydrochloride 99.86% Yes
HY-145574 Iruplinalkib Inhibitor 99.62% Unkown
HY-12215R Lorlatinib (Standard) 99.92% Unkown
HY-50878B Crizotinib acetate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-112801 F-1 Inhibitor 98.03% Phase 3
HY-176942 JYP0322 Inhibitor / Phase 3
HY-152292 Zidesamtinib Inhibitor 99.78% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-155163 APG-2449 Inhibitor 98.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (56)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0578 Apigenin 7-glucoside 98.98% Unkown
HY-W015913S Pyruvic acid-13C3 sodium Inhibitor 99.7% Unkown
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-122311 Orniplabin Inhibitor 98% Unkown
HY-159147 SIA​​IS039 99.68% Unkown
HY-12678S1 Entrectinib-d8 99.82% Unkown
HY-N7798 Pennogenin 99.90% Unkown
HY-50878S Crizotinib-d5 99.60% Unkown
HY-B1106 Tetrahydroxyquinone 98.0% Unkown
HY-12678S Entrectinib-d4 Inhibitor / Unkown
HY-B1106A Tetrahydroxyquinone monohydrate 97.0% Unkown
HY-N10144 Shinpterocarpin Inhibitor / Unkown
HY-N1306 Sideroxylin / Unkown
HY-N2693 6,8-Diprenylorobol 98.40% Unkown
HY-W015913R Pyruvic acid sodium (Standard) Inhibitor 99.98% Unkown
HY-161358 FAK-IN-20 / Unkown
HY-111416 WY-135 Inhibitor / Unkown
HY-131003A Taletrectinib free base Inhibitor / Unkown
HY-135509 Lorlatinib acetate / Unkown
HY-115541 BRD4-IN-41 Inhibitor / Unkown
HY-117420 CM764 Activator / Unkown
HY-120387 SMU-B Inhibitor / Unkown
HY-122311A Bis(2R,3R)-Orniplabin 95.0% Unkown
HY-123454 SKF1 / Unkown
HY-130794 ALK/ROS1-IN-1 Inhibitor / Unkown
HY-144697 p38 MAPK-IN-3 / Unkown
HY-147795 Nampt-IN-8 / Unkown
HY-150974 ROS1-IN-1 Inhibitor / Unkown
HY-153743 Protein kinase inhibitor 4 Inhibitor / Unkown
HY-155178 Antiproliferative agent-34 Inhibitor / Unkown
HY-156360 Xanthine oxidase-IN-12 Inhibitor / Unkown
HY-157391 ALK/ROS1-IN-3 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-158016 Antiproliferative agent-49 / Unkown
HY-161966 VEGFR-2-IN-52 / Unkown
HY-161975 ROS1-IN-2 Inhibitor / Unkown
HY-162311 Anticancer agent 194 / Unkown
HY-163862 PPARα agonist 3 / Unkown
HY-170418 ALK/ROS1-IN-5 / Unkown
HY-178391 SMU-037 / Unkown
HY-179052 Apoptosis inducer 50 / Unkown
HY-179527 LIG48 Inhibitor / Unkown
HY-50878AS Crizotinib-d9 hydrochloride / Unkown
HY-N11887 Linocinnamarin Inhibitor 99.14% Unkown
HY-RS12135 ROS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12136 Ros1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12137 ROS1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160172 ALK/ROS1-IN-4 Inhibitor / Unkown
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / Unkown
HY-162488 Laccase-IN-3 Inhibitor / Unkown
HY-179710 SET-12 / Unkown
HY-50878S1 Crizotinib-d8 / Unkown
HY-50878S2 Crizotinib-d9 / Unkown
HY-B0847S Propiconazole-d7 / Unkown
HY-W587743 N1-Acetyl-5-methoxykynuramine hydrochloride Inhibitor / Unkown
HY-W927359 Fluorescein hydrazide (3,6-Dihydroxyxanthane) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ros1 NCBI NCBI:6098