Rigi - RNA sensor RIG-I Gene

Also Known as Ddx58; RIG-I; RLR-1; C330021E21; 6430573D20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230073

Summary

Enables double-stranded DNA binding activity; double-stranded RNA binding activity; and single-stranded RNA binding activity. Involved in innate immune response; positive regulation of cytokine production; and response to virus. Acts upstream of or within response to exogenous dsRNA. Predicted to be located in several cellular components, including actin cytoskeleton; bicellular tight junction; and ruffle membrane. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; olfactory epithelium; ovary; and renal calyx. Orthologous to human DDX58 (DExD/H-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]

Rigi Products (1)

mRNA Protein Name
NM_172689.3 NP_766277.3 antiviral innate immune response receptor RIG-I
Protein Preferred Names Protein Names

antiviral innate immune response receptor RIG-I

  • ATP-dependent RNA helicase DDX58

  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

  • DEAD box protein 58

  • DEAD/H box helicase 58

  • DEAD/H box polypeptide RIG-I

  • RIG-1

  • RIG-I-like receptor 1

  • probable ATP-dependent RNA helicase DDX58

  • retinoic acid-inducible gene 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101954A Inarigivir ammonium Inhibitor 99.04% Phase 2
HY-101954 Inarigivir Inhibitor 99.20% Phase 2

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107202 Polyinosinic-polycytidylic acid 99.40% Unkown
HY-135748 Polyinosinic-polycytidylic acid sodium 99.40% Unkown
HY-147124 RIG012 Inhibitor 99.33% Unkown
HY-126675A AS2863619 98.02% Unkown
HY-107202A Poly (I:C):Kanamycin (1:1) 48.6% Unkown
HY-160229 ssRNA40 sodium 98.34% Unkown
HY-P1934A Cyclo(L-Phe-L-Pro) Inhibitor 99.75% Unkown
HY-P1934 Cyclo(Phe-Pro) Inhibitor 99.22% Unkown
HY-W013403 2'-Deoxy-2'-fluorouridine 99.91% Unkown
HY-107202GL Polyinosinic-polycytidylic acid (GMP Like) 90.5% Unkown
HY-135748A Poly (I:C):Kanamycin (1:1) sodium 99.0% Unkown
HY-126675 AS2863619 free base 99.87% Unkown
HY-N0891 Tubeimoside II 99.90% Unkown
HY-123805 KIN1400 98.1% Unkown
HY-126675G AS2863619 (GMP) / Unkown
HY-134958 Polyinosinic-polycytidylic acid potassium / Unkown
HY-179524 ISR activator 2 Activator / Unkown
HY-179539 ISR activator 3 Activator / Unkown
HY-RS11972 RIGI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W013403S 2'-Deoxy-2'-fluorouridine-d2 / Unkown
HY-177817 CL9 sodium / Unkown
HY-181165 SB2960 Inhibitor / Unkown
HY-RS18258 Rigi Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W682115 Poly(C) Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rigi NCBI NCBI:23586