RIGI - RNA sensor RIG-I Gene

Also Known as RIG1; DDX58; RIG-I; RLR-1; SGMRT2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23586

About RIGI

Cytogenetic location: 9p21.1 Genomic coordinates (GRCh38): 9:32,455,302-32,526,196 (from NCBI)

This gene has 10 transcripts (splice variants), 171 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in appendix (RPKM 7.8), spleen (RPKM 7.4) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a Caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the Antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]

RIGI Products (7)

mRNA	Protein	Name
NM_001385907.1	NP_001372836.1	antiviral innate immune response receptor RIG-I isoform 2
NM_001385909.1	NP_001372838.1	antiviral innate immune response receptor RIG-I isoform 3
NM_001385910.1	NP_001372839.1	antiviral innate immune response receptor RIG-I isoform 4
NM_001385912.1	NP_001372841.1	antiviral innate immune response receptor RIG-I isoform 5
NM_001385913.1	NP_001372842.1	antiviral innate immune response receptor RIG-I isoform 6
NM_001385914.1	NP_001372843.1	antiviral innate immune response receptor RIG-I isoform 7
NM_014314.4	NP_055129.2	antiviral innate immune response receptor RIG-I isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	21233210	GOA
enables RNA helicase activity	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	19576794	GOA
enables double-stranded RNA binding	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17190814	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	19576794	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16127453	GOA
enables single-stranded RNA binding	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	23950712	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18243112	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RIG-I signaling pathway	IDA IDA: Inferred from direct assay	28469175	GOA
involved in RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	19211564	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	28469175	GOA
involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	19576794	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in detection of virus	IDA IDA: Inferred from direct assay	17079289	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	24409285	GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production	IDA IDA: Inferred from direct assay	24409285	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	19576794	GOA
involved in positive regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	17079289	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	19609254	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	24409285	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	24409285	GOA
involved in positive regulation of response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17079289	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	21957149	GOA
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	19122199	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	19122199	GOA
located in bicellular tight junction	IDA IDA: Inferred from direct assay	19122199	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	15208624	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21102435	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	31006531	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	19122199	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIGI Protein Structure

DEAD

Helicase_C

RIG-I_C-RD

0
200
400
600
800
925 a.a.

Protein Preferred Names	Protein Names
antiviral innate immune response receptor RIG-I	ATP-dependent RNA helicase DDX58

RIGI Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RIGI	O95786	STAT1	Homo sapiens	P42224	Anti Bait CoIP	24360797
Intra	RIGI	O95786	NPLOC4	Homo sapiens	Q8TAT6	Anti Bait CoIP	26471729
Intra	RIGI	O95786	NPLOC4	Homo sapiens	Q8TAT6	Confocal	26471729
Intra	RIGI	O95786	NPLOC4	Homo sapiens	Q8TAT6	Anti Tag CoIP	26471729
Intra	RIGI	O95786	CYLD	Homo sapiens	Q9NQC7	Anti Bait CoIP	18636086
Intra	RIGI	O95786	RNF125	Homo sapiens	Q96EQ8	Anti Bait CoIP	26471729
Intra	RIGI	O95786	TRIM25	Homo sapiens	Q14258	Anti Tag CoIP	34471099
Intra	RIGI	O95786	TRIM25	Homo sapiens	Q14258	Anti Tag CoIP	35075101
Intra	RIGI	O95786	TRIM25	Homo sapiens	Q14258	Pull Down	20818395
Intra	RIGI	O95786	WRNIP1	Homo sapiens	Q96S55	Anti Tag CoIP	21903422
Cross	RIGI	O95786	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	33396605
Cross	RIGI	O95786	N	SARS-CoV-2	P0DTC9	Confocal	35075101
Cross	RIGI	O95786	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34471099
Cross	RIGI	O95786	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	35075101
Cross	RIGI	O95786	N	SARS-CoV-2	P0DTC9	Confocal	33396605
Cross	RIGI	O95786	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Confocal	35075101
Cross	RIGI	O95786	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Anti Tag CoIP	34544279
Cross	RIGI	O95786	P0DTD1-PRO_0000449623	SARS-CoV-2	P0DTD1-PRO_0000449623	Anti Tag CoIP	35075101
Cross	RIGI	O95786	Z	Junin mammarenavirus	Q6IVU5	Anti Tag CoIP	20007272
Cross	RIGI	O95786	Z	Junin mammarenavirus	Q6IVU5	Anti Bait CoIP	20007272
Cross	RIGI	O95786	Z	Machupo virus	Q6IUF9	Anti Tag CoIP	20007272
Cross	RIGI	O95786	1B	Human respiratory syncytial virus A	P04543	Anti Tag CoIP	19193793
Intra	RIGI	O95786	PRKRA	Homo sapiens	O75569	Anti Bait CoIP	23870315
Intra	RIGI	O95786	NOP53	Homo sapiens	Q9NZM5	Anti Tag CoIP	27824081
Intra	RIGI	O95786	ZC3HAV1	Homo sapiens	Q7Z2W4	Anti Bait CoIP	21102435
Intra	RIGI	O95786	ZC3HAV1	Homo sapiens	Q7Z2W4	Anti Tag CoIP	21102435
Intra	RIGI	O95786	ZC3HAV1	Homo sapiens	Q7Z2W4-2	FRET	21102435
Intra	RIGI	O95786	ZC3HAV1	Homo sapiens	Q7Z2W4-2	Confocal	21102435
Intra	RIGI	O95786	ZC3HAV1	Homo sapiens	Q7Z2W4-2	SPR	21102435
Cross	RIGI	O95786	NSS	sfts virus hb29	A0A0B5AC19	Confocal	24478431
Intra	RIGI	O95786	MAVS	Homo sapiens	Q7Z434	Anti Bait CoIP	20007272
Intra	RIGI	O95786	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	21903422
Intra	RIGI	O95786	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	19193793
Intra	RIGI	O95786	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	19164550
Intra	RIGI	O95786	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	22301138
Intra	RIGI	O95786	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	34544279
Intra	RIGI	O95786	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	35075101
Intra	RIGI	O95786	MAVS	Homo sapiens	Q7Z434	Anti Tag CoIP	16177806
Cross	RIGI	O95786	Casp12	Rattus norvegicus	Q920D5	IF	20818395
Cross	RIGI	O95786	Casp12	Rattus norvegicus	Q920D5	Pull Down	20818395
Cross	RIGI	O95786	Z	Guanarito mammarenavirus	Q6UY71	Anti Bait CoIP	20007272
Cross	RIGI	O95786	Z	Guanarito mammarenavirus	Q6UY71	Anti Tag CoIP	20007272
Cross	RIGI	O95786	Z	Sabia mammarenavirus	Q6UY62	Anti Tag CoIP	20007272
Cross	RIGI	O95786	US11	Human herpesvirus 1	P04487	Anti Tag CoIP	22301138

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RIGI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72170	DDX58 Protein, Human (His)	O95786 (M1-L430)	≥ 90%, as determined by reducing SDS-PAGE.

RIGI Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82573	DDX58 Antibody (YA2318)	WB, IP	Human
HY-P83877	DDX58 Antibody (YA3574)	ICC/IF, FC, ELISA	Human
HY-P83877A	DDX58 Antibody (YA3574)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P86185	DDX58 Antibody (YA5877)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Singleton-Merten Syndrome 2	SGMRT2 Singleton-Merten Syndrome, Type 2
Singleton-Merten Syndrome	Singleton-Merten Dysplasia Widened Medullary Cavities Of Bone, Aortic Calcification, Abnormal Dentition, And Muscular Weakness Singleton Merten Syndrome Merten-Singleton Syndrome Sm Syndrome Syndrome Of Widened Medullary Cavities Of The Metacarpals And Phalanges, Aortic Calcification And Abnormal Dentition
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Stomatitis
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Yellow Fever	Urban Yellow Fever Jungle Yellow Fever Sylvatic Yellow Fever Yf Yellow Fever, Sylvan Bronze John Yellow Jack Yf- [Yellow Fever] Febris Flava
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Newcastle Disease	Newcastle'S Disease Pseudo-Fowlpest
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Mouth Disease	Mouth Diseases Mouth Disorders
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Rabies	Lyssa Hydrophobia St Hubert Disease
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Rubella	German Measles Three Day Measles Rubella Nos
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Hepatitis E
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Psoriasis
Lassa Fever	Lf Lassa Hemorrhagic Fever Lf - [Lassa Fever]
Trichohepatoenteric Syndrome 1	Trichohepatoenteric Syndrome Syndromic Diarrhea Tricho-Hepato-Enteric Syndrome Sd/The Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome THES1 Phenotypic Diarrhea Thes Phenotypic Diarrhea Of Infancy Diarrhea, Syndromic Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa Intractable Diarrhea With Phenotypic Anomalies Syndromatic Diarrhea Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Swine Influenza	Influenza Due To Influenza A Virus Subtype H1n1
Argentine Hemorrhagic Fever	Argentinian Hemorrhagic Fever Junin Hemorrhagic Fever Hemorrhagic Fever, Argentinian Ahf - [Argentinian Haemorrhagic Fever] Argentine Haemorrhagic Fever Junin Haemorrhagic Fever
Herpangina	Vesicular Pharyngitis
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Bolivian Hemorrhagic Fever	Machupo Hemorrhagic Fever Hemorrhagic Fever, Bolivian Bhf - [Bolivian Haemorrhagic Fever] Machupo Haemorrhagic Fever
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Zika Fever	Zika Virus Infection Zika Virus Disease Zika Virus Zika Virus Fever Mosquito-Borne Viral Fever, Zika
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
Hantavirus Pulmonary Syndrome	Hps Four Corners Hantavirus Hards Hantavirus Hantavirus-Associated Respiratory Distress Syndrome Hanta Virus Hantavirus Cardiopulmonary Syndrome Hps - [Hantavirus Pulmonary Syndrome] Hcps - [Hantavirus Cardiopulmonary Syndrome]
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Poliomyelitis	Polio Infantile Paralysis
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Viral Encephalitis	Epidemic Encephalitis Encephalitis Viral Encephalitis, Arbovirus Arbovirus Encephalitis Postviral Encephalitis Nos Equine Encephalitis Tick-Borne Encephalitis Viral Encephalitis Transmitted By Tick Mosquito-Borne Encephalitis Acute Haemorrhagic Encephalitis Acute Idiopathic Encephalitis Chronic Viral Encephalitis Endemic Encephalitis Subacute Viral Encephalitis Viral Haemorrhagic Encephalitis Viral Nonepidemic Encephalitis Nonepidemic Encephalitis
Croup	Acute Obstructive Laryngitis Laryngotracheobronchitis Acute Laryngotracheobronchitis Croup Syndrome Acute Laryngitis With Obstruction Obstructive Laryngitis Obstructive Laryngitis Nos Obstructive Laryngotracheitis Nos
Dengue Shock Syndrome	Dss
Dengue Hemorrhagic Fever	Severe Dengue Dengue Haemorrhagic Fever Dhf Severe Dengue Haemorrhagic Fever Severe Dengue Fever Dengue Shock Syndrome
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Dengue Disease	Dengue Fever Dengue Df Dengue Shock Syndrome Dengue Virus Infection Breakbone Fever Classic Dengue Classical Dengue Dengue Hemorrhagic Fever Hemorrhagic Dengue Philippine Hemorrhagic Fever Singapore Hemorrhagic Fever Thai Hemorrhagic Fever Severe Dengue Dengue Fever Without Warning Signs Dengue Haemorrhagic Fever Grade 1 Dengue Haemorrhagic Fever Without Warning Signs Bangkok Haemorrhagic Fever Singapore Haemorrhagic Fever Thailand Haemorrhagic Fever Southeast Asia Haemorrhagic Fever Dhf -[Dengue Haemorrhagic Fever] Dengue Fever With Warning Signs Dengue Haemorrhagic Fever With Warning Signs Dengue Haemorrhagic Fever Grade 2 Philippine Haemorrhagic Fever
West Nile Fever
Hantavirus Hemorrhagic Fever With Renal Syndrome	Hemorrhagic Fever, Russian Hemorrhagic Nephrosonephritis Hfrs Puumala Virus Nephropathy Hemorrhagic Fever With Renal Syndrome
Coronavirus Infectious Disease
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Crv Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Atrial Septal Defect 8	ASD8 Atrial Heart Septal Defect 8 Septal Defect, Atrial, Type 8
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101954A	Inarigivir ammonium	Inhibitor	99.04%	Phase 2

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107202	Polyinosinic-polycytidylic acid		99.40%	Unkown
HY-135748	Polyinosinic-polycytidylic acid sodium		99.40%	Unkown
HY-147124	RIG012	Inhibitor	99.33%	Unkown
HY-126675A	AS2863619		98.02%	Unkown
HY-107202A	Poly (I:C):Kanamycin (1:1)		48.6%	Unkown
HY-160229	ssRNA40 sodium		98.34%	Unkown
HY-P1934A	Cyclo(L-Phe-L-Pro)	Inhibitor	99.75%	Unkown
HY-P1934	Cyclo(Phe-Pro)	Inhibitor	99.22%	Unkown
HY-W013403	2'-Deoxy-2'-fluorouridine		99.91%	Unkown
HY-107202GL	Polyinosinic-polycytidylic acid (GMP Like)		90.5%	Unkown
HY-135748A	Poly (I:C):Kanamycin (1:1) sodium		99.0%	Unkown
HY-126675	AS2863619 free base		99.87%	Unkown
HY-N0891	Tubeimoside II		99.90%	Unkown
HY-123805	KIN1400		98.1%	Unkown
HY-101954	Inarigivir	Inhibitor	99.20%	Unkown
HY-126675G	AS2863619 (GMP)		/	Unkown
HY-134958	Polyinosinic-polycytidylic acid potassium		/	Unkown
HY-179524	ISR activator 2	Activator	/	Unkown
HY-179539	ISR activator 3	Activator	/	Unkown
HY-RS11972	RIGI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W013403S	2'-Deoxy-2'-fluorouridine-d2		/	Unkown
HY-177817	CL9 sodium		/	Unkown
HY-181165	SB2960	Inhibitor	/	Unkown
HY-RS18258	Rigi Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W682115	Poly(C)	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RIGI	VGNC	VGNC:71672
Felis catus	RIGI	VGNC	VGNC:61418
Mus musculus	RIGI	MGD	MGI:2442858
Canis familiaris	RIGI	VGNC	VGNC:39867
Rattus norvegicus	RIGI	RGD	RGD:1309460
Bos taurus	RIGI	VGNC	VGNC:27979
Others	RIGI	NCBI