2. Gene
  3. Apc - APC regulator of WNT signaling pathway Gene

Apc - APC regulator of WNT signaling pathway Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RATAPC

Gene ID: 24205 | Gene type: protein coding

About Apc

Primary_assembly 18: 25,864,222-25,922,696 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 90 phenotypes. Biased expression in Brain (RPKM 51.2), Lung (RPKM 138.6) and 9 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Located in several cellular components, including axonal growth cone; cell body fiber; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with neuron projection and synapse. Used to study anemia; colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial Cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]

Apc Products(1)

mRNA Protein Name
NM_012499.1 NP_036631.1 adenomatous polyposis coli protein

Apc Protein Structure

Suppressor_APC

Suppressor_APC: pfam11414 (134 - 214)

ARM

ARM: smart00185 (347 - 399)

APC_rep

APC_rep: pfam18797 (400 - 473)

ARM

ARM: sd00043 (497 - 533)

ARM

ARM: smart00185 (537 - 578)

ARM

ARM: sd00043 (541 - 578)

ARM

ARM: sd00043 (588 - 620)

ARM

ARM: sd00043 (628 - 669)

ARM

ARM: smart00185 (674 - 714)

ARM

ARM: sd00043 (678 - 712)

Arm

Arm: pfam00514 (716 - 756)

ARM

ARM: sd00043 (720 - 756)

Arm_APC_u3

Arm_APC_u3: pfam16629 (757 - 1044)

APC_u5

APC_u5: pfam16630 (1061 - 1160)

APC_r

APC_r: pfam05923 (1281 - 1298)

APC_u9

APC_u9: pfam16633 (1307 - 1392)

APC_r

APC_r: pfam05923 (1662 - 1685)

APC_u13

APC_u13: pfam16634 (1687 - 1739)

SAMP

SAMP: pfam05924 (1741 - 1762)

APC_u14

APC_u14: pfam16635 (1771 - 1864)

APC_u15

APC_u15: pfam16636 (1898 - 1972)

SAMP

SAMP: pfam05924 (2059 - 2078)

APC_basic

APC_basic: pfam05956 (2250 - 2595)

EB1_binding

EB1_binding: pfam05937 (2697 - 2869)

  • 0
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  • 2500
  • 2870 a.a.
Protein Preferred Names Protein Names

adenomatous polyposis coli protein

APC, WNT signaling pathway regulator

WNT signaling pathway regulator

adenomatosis polyposis coli

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110287 Apcin Inhibitor 99.71% Unkown
HY-124955 proTAME Inhibitor 99.94% Unkown
HY-130841 Apcin-A Inhibitor ≥98.0% Unkown
HY-13255 TAME Inhibitor 99.51% Unkown
HY-13255A TAME hydrochloride Inhibitor 98.43% Unkown
HY-P5819 xStAx-VHLL Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apc NCBI NCBI:324
Macaca fascicularis Apc NCBI NCBI:102126553
Mus musculus Apc NCBI NCBI:11789
Susscrofa domestica Apc NCBI