Hp - haptoglobin Gene

Also Known as Ba1-647

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24464

Summary

Enables Hemoglobin binding activity and identical protein binding activity. Involved in several processes, including response to X-ray; response to growth hormone; and response to vitamin. Located in Golgi apparatus; blood microparticle; and endoplasmic reticulum. Used to study obesity and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); hepatocellular adenoma; kidney failure (multiple); and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Plasmodium falciparum malaria; artery disease (multiple); gout; hemolytic anemia; and hyperglycemia. Orthologous to several human genes including HP (haptoglobin). [provided by Alliance of Genome Resources, Apr 2022]

Hp Products (1)

mRNA Protein Name
NM_012582.2 NP_036714.2 haptoglobin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hemoglobin binding IDA
IDA: Inferred from direct assay
6279649 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
6863267 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
12379430 RGD
involved in liver development IDA
IDA: Inferred from direct assay
16172914 RGD
involved in response to L-ascorbic acid IEP
IEP: Inferred from expression pattern
9566989 RGD
involved in response to X-ray IEP
IEP: Inferred from expression pattern
12379430 RGD
involved in response to cobalamin IEP
IEP: Inferred from expression pattern
12769818 RGD
involved in response to dimethyl sulfoxide IEP
IEP: Inferred from expression pattern
14757319 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
9435654 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
9749840 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
16127721 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
3094379 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
9082656 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
16968543 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
11300617 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15856910 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
19053136 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15899029 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
9432136 RGD
Cellular Component GO Annotation Evidence References Source
located in blood microparticle IDA
IDA: Inferred from direct assay
22014850 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17161237 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

haptoglobin

  • liver regeneration-related protein LRRG173

  • zonulin

Recombinant Hp Proteins

Cat. No. Product Name Accession Purity
HY-P73934 Haptoglobin Protein, Rat (HEK293, His) P06866 (V19-N347) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101588 Gefapixant Antagonist 99.93% Yes
HY-17410 Iloperidone Antagonist 99.93% Unkown
HY-101588A Gefapixant citrate Antagonist 99.23% Unkown
HY-17410A Iloperidone hydrochloride Antagonist / Unkown

Clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Phase
HY-101103 HP-β-CD 99.74% Phase 3
HY-136026 Camlipixant Antagonist 99.76% Phase 3
HY-127165 Velnacrine Inhibitor 98.79% Phase 3
HY-W011246 Velnacrine maleate Inhibitor 98.0% Phase 3
HY-15376 Besipirdine Antagonist / Phase 3
HY-123857 JNJ-55308942 Antagonist 99.92% Phase 2
HY-117508 JNJ-54175446 Antagonist 98.84% Phase 2
HY-135427 Quilostigmine Inhibitor / Phase 2
HY-106016 HP 184 Activator / Phase 2
HY-W050088 Isoxepac 99.97% Phase 1
HY-P4669 LM-030 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (67)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114364 UDP-Galactose disodium Agonist 99.73% Unkown
HY-15568 A-317491 Antagonist 98.64% Unkown
HY-151480 HP590 98.02% Unkown
HY-110329 ML179 Agonist 99.73% Unkown
HY-15568A A-317491 sodium salt hydrate Antagonist 99.88% Unkown
HY-154840 4-Thiouridine 5′-triphosphate tetralithium Agonist 87.53% Unkown
HY-E70058 α-1-3,4 Fucosyltransferase, helicobacter pylori 90.00% Unkown
HY-P1397A RVD-Hpα TFA Agonist 98.92% Unkown
HY-114364S UDP-α-D-Galactose-13C disodium 99% Unkown
HY-127165S2 Velnacrine-d4 hydrochloride 98.61% Unkown
HY-121870 Dimethocaine Substrate 99.90% Unkown
HY-146564 R-HP210 98.21% Unkown
HY-146564A HP210 Modulator 98.96% Unkown
HY-P5310 IgA1 Peptide HP 99.89% Unkown
HY-127165S Velnacrine-d3 / Unkown
HY-17410S Iloperidone-d3 Antagonist 98.8% Unkown
HY-105463 Saptomycin D Inhibitor / Unkown
HY-106508 Fendosal Inhibitor 99.82% Unkown
HY-108654 PSB 0474 / Unkown
HY-127165S1 Velnacrine-d3 maleate / Unkown
HY-127165S3 Velnacrine-d4 / Unkown
HY-136092 Androsta-1,4,6-triene-3,17-dione Inhibitor 95.0% Unkown
HY-143576 P2X3 antagonist 37 Antagonist / Unkown
HY-145690 HP1328 Inhibitor / Unkown
HY-145691 HP1142 Inhibitor / Unkown
HY-146561 S-HP210 Modulator 98.12% Unkown
HY-150524 UDP-Galactose Agonist / Unkown
HY-153710 P2X3 antagonist 38 Antagonist / Unkown
HY-156203 MRS4608 Antagonist / Unkown
HY-156220 MRS4654 Inhibitor / Unkown
HY-167855 MRS4833 Antagonist / Unkown
HY-167855S 1’-Epi Gemcitabine hydrochloride-13C,15N2 / Unkown
HY-170598 HP211206 Inhibitor / Unkown
HY-17410S1 Iloperidone-d3 hydrochloride Antagonist / Unkown
HY-175196 P2X7 receptor antagonist-6 Antagonist / Unkown
HY-175729 Cyclin A/B RxL-IN-1 Inhibitor / Unkown
HY-178006 MRS4917 Antagonist / Unkown
HY-178461 LDHA-IN-10 Inhibitor / Unkown
HY-179373 UB-MBX-46 Antagonist / Unkown
HY-179446 HP1-IN-2 Inhibitor / Unkown
HY-B2085 Arsthinenol Inhibitor / Unkown
HY-E70064A Helicobacter pylori alpha-1,3-fucosyltransferase / Unkown
HY-NP0236 Cynomolgus Monkey haptoglobin / Unkown
HY-NP226 Helicobacter pylori protein / Unkown
HY-P10539 Hp1404 Inhibitor / Unkown
HY-P11151 HPA3NT3-A2 Inhibitor / Unkown
HY-P1397 RVD-Hpα Agonist / Unkown
HY-RS03793 DLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06124 HEPH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06331 HP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06332 HP1BP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06343 HPR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011246S Velnacrine-d3-1 maleate / Unkown
HY-W050088S Isoxepac-d6 / Unkown
HY-14607 Besipirdine hydrochloride Inhibitor / Unkown
HY-154840A 4-Thiouridine 5′-triphosphate tetrasodium Agonist / Unkown
HY-168117 HP-101 Inhibitor / Unkown
HY-170599 H117 Inhibitor 99.27% Unkown
HY-170600 Boc-Ala(Me)-H117 / Unkown
HY-171951 31hP / Unkown
HY-17410S2 Iloperidone-13C,d3 Antagonist / Unkown
HY-RS16740 Hp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18035 Heph Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19126 Dlc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23177 Hp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W097612 P2X4 antagonist-5 Control 99.14% Unkown
HY-108668 TC-P 262 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hp NCBI NCBI:3240