Ttr - transthyretin Gene

Also Known as TT; Lr1; Tbpa

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24856

About Ttr

Primary_assembly 18: 11,943,789-11,951,008 forward strand.mRatBN7.2:CM026991.1

This gene has 1 transcript (splice variant), 178 orthologues, 2 paralogues and is associated with 41 phenotypes. Restricted expression toward (RPKM 5128.3).

Summary

Enables hormone binding activity. Predicted to be involved in purine nucleobase metabolic process. Located in extracellular space. Part of protein-containing complex. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). [provided by Alliance of Genome Resources, Apr 2022]

Ttr Products (1)

mRNA Protein Name
NM_012681.2 NP_036813.2 transthyretin precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone binding IDA
IDA: Inferred from direct assay
11995998 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9260907 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11995998 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
9260907 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ttr Protein Structure

TR_THY

TR_THY: smart00095 (26 - 146)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

transthyretin

  • prealbumin, amyloidosis type I

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132609 Patisiran sodium 99.09% Unkown
HY-14852 Tafamidis Inhibitor 99.93% Yes
HY-132608 Inotersen sodium 96.44% Unkown
HY-132589A Vutrisiran sodium Inhibitor 97.37% Unkown
HY-14852A Tafamidis meglumine 99.95% Yes
HY-148089A Eplontersen sodium Inhibitor 96.95% Unkown
HY-109165 Acoramidis 98.47% Unkown
HY-112974 Inotersen Inhibitor 96.44% Unkown
HY-109165A Acoramidis hydrochloride 98.70% Unkown
HY-14852R Tafamidis (Standard) Inhibitor 99.24% Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-132589 Vutrisiran 97.37% Phase 3
HY-148089 Eplontersen Inhibitor 98.70% Phase 3
HY-177650 Nucresiran Inhibitor 97.24% Phase 3
HY-185504 Nexiguran / Phase 3
HY-132590 Revusiran / Phase 3
HY-177650A Nucresiran sodium Inhibitor / Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990734 Coramitug Inhibitor 99.00% Phase 1

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N1957 Gamma-Mangostin 99.91% Unkown
HY-113283 Homogentisic acid 99.68% Unkown
HY-132590A Revusiran sodium Inhibitor 93.16% Unkown
HY-153609 AS-Patisiran sodium Inhibitor 95.10% Unkown
HY-W331198 Tralopyril Inducer 99.70% Unkown
HY-113950 Dichlorophenyl-ABA 99.79% Unkown
HY-153577 WT-TTR inhibitor 1 Inhibitor 98.03% Unkown
HY-RS15238 TTR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-165604 C14-490 98% Unkown
HY-146137 Transthyretin-IN-1 / Unkown
HY-147366 RBP4 ligand-1 Inhibitor / Unkown
HY-14852S Tafamidis-d3 / Unkown
HY-155299 PITB Inhibitor / Unkown
HY-159658 TTR stabilizer 1 Modulator / Unkown
HY-161505 Transthyretin-IN-3 Inhibitor / Unkown
HY-P10615 Abz-YGGRASDQ-EDDnp / Unkown
HY-P11698 Guanidino-G-Clamp-PNA Inhibitor / Unkown
HY-RS15239 Ttr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15240 Ttr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126927 TTR stabilizer L6 Modulator / Unkown
HY-160612 Transthyretin-IN-2 Inhibitor / Unkown
HY-176233 Transthyretin-IN-4 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991128 Cliramitug 97.0% Unkown
HY-P991412 NI-301 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ttr NCBI NCBI:7276