Dmd - dystrophin Gene

Also Known as DNADMD1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24907

Summary

Enables several functions, including PDZ domain binding activity; Integrin binding activity; and lamin binding activity. Involved in several processes, including nervous system development; regulation of neuron differentiation; and response to denervation involved in regulation of muscle adaptation. Located in several cellular components, including mitochondrial membrane; neurofilament; and secretory vesicle. Part of dystrophin-associated glycoprotein complex. Used to study Duchenne muscular dystrophy; brain edema; and dilated cardiomyopathy. Biomarker of muscular atrophy; retinal degeneration; and status epilepticus. Human ortholog(s) of this gene implicated in cognitive disorder; dilated cardiomyopathy (multiple); intellectual disability; and muscular dystrophy (multiple). Orthologous to human DMD (Dystrophin). [provided by Alliance of Genome Resources, Apr 2022]

Dmd Products (4)

mRNA Protein Name
NM_001005244.2 NP_001005244.1 dystrophin isoform Dp71ab
NM_001005246.1 NP_001005246.1 dystrophin isoform Dp71c
NM_001370876.1 NP_001357805.1 dystrophin isoform 1
NM_012698.3 NP_036830.2 dystrophin isoform Dp71a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
15024025 RGD
enables actin binding IDA
IDA: Inferred from direct assay
10984432 RGD
enables integrin binding IPI
IPI: Inferred from physical interaction
18677563 RGD
enables lamin binding IPI
IPI: Inferred from physical interaction
21886794 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10545507 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
15247274 RGD
Biological Process GO Annotation Evidence References Source
involved in cell differentiation IEP
IEP: Inferred from expression pattern
22008482 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
1454857 RGD
involved in muscle cell differentiation IEP
IEP: Inferred from expression pattern
19903098 RGD
involved in negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
21668890 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
8858620 RGD
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
15706226 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21886794 RGD
involved in positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15149856 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
15149856 RGD
involved in regulation of cellular response to growth factor stimulus IMP
IMP: Inferred from mutant phenotype
15149856 RGD
involved in response to denervation involved in regulation of muscle adaptation IEP
IEP: Inferred from expression pattern
8906620 RGD
involved in skeletal muscle tissue regeneration IEP
IEP: Inferred from expression pattern
12086334 RGD
Cellular Component GO Annotation Evidence References Source
located in astrocyte projection IDA
IDA: Inferred from direct assay
10411999 RGD
located in axon IDA
IDA: Inferred from direct assay
9858364 RGD
located in cell projection IDA
IDA: Inferred from direct assay
11368101 RGD
part of dystrophin-associated glycoprotein complex IDA
IDA: Inferred from direct assay
15247274 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
11368101 RGD
located in matrix side of mitochondrial inner membrane IDA
IDA: Inferred from direct assay
10913331 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
10411999 RGD
located in myofibril IDA
IDA: Inferred from direct assay
12890920 RGD
located in neurofilament IDA
IDA: Inferred from direct assay
11326752 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10359335 RGD
located in nucleus IDA
IDA: Inferred from direct assay
15149856 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11368101 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
10545507 RGD
located in ribosome IDA
IDA: Inferred from direct assay
10411999 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
12037582 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
9858364 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
1454857 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dystrophin

  • apodystrophin-3

  • apodystrophin-I

  • dystrophin, muscular dystrophy

  • dystrophin-related

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-132611 Golodirsen 96.12% Unkown
HY-132611A Golodirsen sodium Modulator 92.00% Unkown
HY-132584A Casimersen sodium 98.50% Unkown
HY-132584 Casimersen 92.50% Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-132586 Viltolarsen Modulator 95.25% Phase 4
HY-108753 Eteplirsen 98.50% Phase 3
HY-14931 Naproxcinod Inhibitor / Phase 3
HY-134377 Bocidelpar Modulator 98.08% Phase 2
HY-17614 Ezutromid 98.87% Phase 2
HY-127137 Adenylosuccinic acid 99.74% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99857 Domagrozumab Inhibitor 96.34% Phase 2

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152182 ML-SA5 Agonist 99.69% Unkown
HY-147332 TCL053 99.97% Unkown
HY-15898 Y-320 99.03% Unkown
HY-132586A Viltolarsen sodium Modulator 95.25% Unkown
HY-101459 RTC13 98.01% Unkown
HY-122631 TG693 99.95% Unkown
HY-127137A Adenylosuccinic acid tetraammonium 99.62% Unkown
HY-139972 PROTAC(H-PGDS)-7 99.42% Unkown
HY-114739 MA-0204 Modulator 99.31% Unkown
HY-153369 BAY-747 Activator 98.01% Unkown
HY-122588A Negamycin hydrochloride 80.0% Unkown
HY-150237 FITC-labeled Drisapersen sodium Inhibitor 92.99% Unkown
HY-RS03823 DMD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147253 Brogidirsen / Unkown
HY-150077 Utrophin modulator 1 / Unkown
HY-150078 OX01914 / Unkown
HY-177659 Rimigorsen Inhibitor / Unkown
HY-177659A Rimigorsen sodium Inhibitor / Unkown
HY-185926 Idalaptican pegol / Unkown
HY-RS18019 Dmd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24492 Dmd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990051 Delpacibart 98.06% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dmd NCBI NCBI:1756