Hmgcr - 3-hydroxy-3-methylglutaryl-CoA reductase Gene

Also Known as 3H3M

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25675

About Hmgcr

Primary_assembly 2: 27,997,525-28,019,703 reverse strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 206 orthologues and is associated with 39 phenotypes. Biased expression in Liver (RPKM 17.6), Brain (RPKM 11.7) and 9 other tissues.

Summary

Enables identical protein binding activity and protein Phosphatase 2A binding activity. Involved in several processes, including lipid homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Located in intracellular membrane-bounded organelle. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Apr 2022]

Hmgcr Products (1)

mRNA Protein Name
NM_013134.2 NP_037266.2 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
4019513 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
18031790 RGD
Biological Process GO Annotation Evidence References Source
involved in cholesterol homeostasis IEP
IEP: Inferred from expression pattern
23117815 RGD
involved in myoblast differentiation IEP
IEP: Inferred from expression pattern
20336669 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15385411 RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
20610886 RGD
involved in negative regulation of striated muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19505369 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17161379 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19298698 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12713866 RGD
involved in positive regulation of skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
19388010 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
18413661 RGD
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
17161379 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
19221211 RGD
involved in response to cholesterol IEP
IEP: Inferred from expression pattern
25263431 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
20041784 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
16702306 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
23117815 RGD
involved in triglyceride homeostasis IEP
IEP: Inferred from expression pattern
23117815 RGD
involved in ubiquinone metabolic process IMP
IMP: Inferred from mutant phenotype
17192694 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hmgcr Protein Structure

2A060605

2A060605: TIGR00920 (10 - 896)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 897 a.a.
Protein Preferred Names Protein Names

3-hydroxy-3-methylglutaryl-coenzyme A reductase

  • HMG-CoA reductase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17504 Rosuvastatin Calcium 99.62% Yes
HY-17504B Rosuvastatin Sodium 99.91% Yes
HY-119695A Simvastatin acid ammonium Inhibitor 99.70% Unkown
HY-115292 Simvastatin hydroxy acid sodium Inhibitor 99.86% Unkown
HY-119695 Simvastatin acid Inhibitor 98.99% Unkown
HY-119695B Simvastatin acid calcium hydrate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-N0466 Rebaudioside A 98.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107855 DL-Mevalonolactone 99.15% Unkown
HY-15483 DY131 99.72% Unkown
HY-N6712 Thiolutin Inhibitor 99.27% Unkown
HY-N0686 Pseudoprotodioscin Inhibitor 99.17% Unkown
HY-111355 Cholesterol sulfate 98.49% Unkown
HY-135700 Mevalonolactone 98.0% Unkown
HY-N0430A Coptisine Sulfate 99.37% Unkown
HY-17504R Rosuvastatin Calcium (Standard) 99.94% Unkown
HY-W414548 7α,27-Dihydroxycholesterol 99.93% Unkown
HY-114316 HMG499 Inhibitor 96.12% Unkown
HY-142026 Vitisin A 97% Unkown
HY-17504BS1 Rosuvastatin-d6 sodium Inhibitor 99.9% Unkown
HY-106281 Bemfivastatin Inhibitor 99.48% Unkown
HY-106281A Bemfivastatin hemicalcium Inhibitor 98.00% Unkown
HY-N0430 Coptisine / Unkown
HY-RS06238 HMGCR Human Pre-designed siRNA Set A / Unkown
HY-W740010 N-Desmethyl rosuvastatin disodium hydrate 99.1% Unkown
HY-17504BS2 Rosuvastatin-13C,d3 sodium 98.31% Unkown
HY-N11637 Ganoderenic acid K Inhibitor 99.64% Unkown
HY-107855S2 DL-Mevalonolactone-13C / Unkown
HY-107855S4 DL-Mevalonolactone-13C2 / Unkown
HY-115292S Simvastatin hydroxy acid-d6 sodium Inhibitor / Unkown
HY-116241 L-157012 Inhibitor / Unkown
HY-119695AS1 Simvastatin acid-d9 ammonium Inhibitor / Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-171823 PROTAC HMGCR Degrader-1 Degrader / Unkown
HY-181134 PROTAC HMGCR Degrader-2 / Unkown
HY-184354 NO-Pravastatin / Unkown
HY-N11637A (Z)-Ganoderenic acid K Control / Unkown
HY-N16439 Phenicin Inhibitor / Unkown
HY-P11881 IUB288 / Unkown
HY-RS06239 Hmgcr Mouse Pre-designed siRNA Set A / Unkown
HY-RS06240 Hmgcr Rat Pre-designed siRNA Set A / Unkown
HY-W752587 DL-Mevalonolactone-d4 / Unkown
HY-107855R DL-Mevalonolactone (Standard) / Unkown
HY-119695S Simvastatin acid-d6 Inhibitor / Unkown
HY-136345A 3'-Hydroxy simvastatin 99.71% Unkown
HY-187569 (Rac)-3-OH-Simvastatin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgcr NCBI NCBI:3156