Fto - fat mass and obesity associated Gene

Also Known as mKIAA1752

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26383

About Fto

Chromosome 8: 92,040,153-92,395,067 forward strand.GRCm39:CM001001.3

This gene has 7 transcripts (splice variants), 202 orthologues and is associated with 54 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 31.5), whole brain E14.5 (RPKM 3.4) and 28 other tissues.

Summary

Enables DNA-N1-methyladenine dioxygenase activity; oxidative DNA demethylase activity; and oxidative RNA demethylase activity. Involved in several processes, including nucleic acid metabolic process; regulation of respiratory system process; and regulation of white fat cell proliferation. Located in nucleus. Is expressed in several structures, including gonad; hemolymphoid system gland; liver; lung; and salivary gland. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Fto Products (1)

mRNA Protein Name
NM_011936.2 NP_036066.2 alpha-ketoglutarate-dependent dioxygenase FTO

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2-oxoglutarate-dependent dioxygenase activity IDA
IDA: Inferred from direct assay
17991826 MGI
enables broad specificity oxidative DNA demethylase activity IDA
IDA: Inferred from direct assay
18775698 MGI
enables oxidative RNA demethylase activity IDA
IDA: Inferred from direct assay
18775698 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA alkylation repair IDA
IDA: Inferred from direct assay
18775698 MGI
involved in RNA repair IDA
IDA: Inferred from direct assay
18775698 MGI
involved in adipose tissue development IMP
IMP: Inferred from mutant phenotype
19234441 MGI
involved in regulation of lipid storage IMP
IMP: Inferred from mutant phenotype
19234441 MGI
involved in regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
19234441 MGI
involved in regulation of respiratory system process IMP
IMP: Inferred from mutant phenotype
19234441 MGI
involved in regulation of white fat cell proliferation IMP
IMP: Inferred from mutant phenotype
19234441 MGI
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
19234441 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17991826 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fto Protein Structure

FTO_NTD

FTO_NTD: pfam12933 (35 - 321)

FTO_CTD

FTO_CTD: cl15176 (325 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

alpha-ketoglutarate-dependent dioxygenase FTO

  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

  • fat mass and obesity-associated protein

  • m6A(m)-demethylase FTO

  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

  • mRNA N(6)-methyladenosine demethylase FTO

  • protein fatso

  • tRNA N1-methyl adenine demethylase FTO

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-B1320 Meclofenamic acid sodium Inhibitor 99.89% Unkown
HY-117275 Meclofenamic acid Inhibitor 99.66% Unkown
HY-101082 N6,2′-O-Dimethyladenosine Inhibitor 99.87% Unkown
HY-14280R Entacapone (Standard) Inhibitor 99.24% Unkown
HY-117275A Meclofenamic acid sodium hydrate Inhibitor 99.83% Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown

Pre-clinical Phase

Bioactive Molecules (39)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-127103 FB23-2 Inducer 99.93% Unkown
HY-137187 FB23 98.88% Unkown
HY-W074785 Carboxyl diazirine alkyne 98.0% Unkown
HY-N6769 Radicicol Inhibitor 99.96% Unkown
HY-129079 TFMB-(R)-2-HG Inhibitor 98.26% Unkown
HY-172158 ALKBH5-IN-5 99.66% Unkown
HY-149334 ZLD115 Inhibitor 99.87% Unkown
HY-173020 W23-1006 97.15% Unkown
HY-138843A FTO-IN-1 TFA 98.06% Unkown
HY-151106 FTO-IN-8 Inhibitor 95.04% Unkown
HY-RS05136 FTO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149145 Ena15 ≥99.0% Unkown
HY-174979 Dac590 96.15% Unkown
HY-145238 FTO-IN-6 98.94% Unkown
HY-147011 FTO-IN-7 Inhibitor 99.22% Unkown
HY-W588293 3-Methylthymidine 99.68% Unkown
HY-117426 MO-I-500 Inhibitor 99.10% Unkown
HY-132865 FTO-IN-3 99.79% Unkown
HY-14280S Entacapone-d10 Inhibitor 98.6% Unkown
HY-168878 EP652 Inhibitor / Unkown
HY-175885 PROTAC FTO degrader 1 / Unkown
HY-131871 Ethyl LipotF Inhibitor 99.25% Unkown
HY-RS05137 Fto Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117275S Meclofenamic acid-d4 Inhibitor / Unkown
HY-117275S1 Meclofenamic acid-13C6 Inhibitor / Unkown
HY-132863 FTO-IN-2 / Unkown
HY-138843 FTO-IN-1 / Unkown
HY-139820 FTO-IN-4 / Unkown
HY-139821 FTO-IN-5 / Unkown
HY-156405 FTO-IN-10 / Unkown
HY-168483 FTO-IN-13 / Unkown
HY-172399 FTO-IN-14 / Unkown
HY-175886 FTO ligand-1 / Unkown
HY-179266 FTO-IN-15 Inhibitor / Unkown
HY-179267 FTO-IN-16 / Unkown
HY-183325 FTO-IN-17 Inhibitor / Unkown
HY-N10340 Clausine E Inhibitor / Unkown
HY-RS05138 Fto Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W026109 FTO-IN-12 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fto NCBI NCBI:79068