ABL1 - ABL proto-oncogene 1, non-receptor tyrosine kinase Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 491292

About ABL1

Primary_assembly 9: 54,019,025-54,161,522 reverse strand.ROS_Cfam_1.0:CM025108.1

This gene has 5 transcripts (splice variants), 204 orthologues and 32 paralogues.

ABL1 Products (2)

mRNA Protein Name
XM_038678276.1 XP_038534204.1 tyrosine-protein kinase ABL1 isoform X1
XM_038678277.1 XP_038534205.1 tyrosine-protein kinase ABL1 isoform X2

ABL1 Protein Structure

SH3_Abl

SH3_Abl: cd11850 (83 - 136)

SH2_ABL

SH2_ABL: cd09935 (141 - 234)

PTKc_Abl

PTKc_Abl: cd05052 (253 - 515)

FABD

FABD: smart00808 (1025 - 1149)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1150 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase ABL1

  • c-abl oncogene 1, non-receptor tyrosine kinase

  • c-abl oncogene 1, receptor tyrosine kinase

  • v-abl Abelson murine leukemia viral oncogene homolog 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104010 Asciminib Inhibitor 99.61% Yes
HY-104010A Asciminib hydrochloride Inhibitor 99.84% Yes
HY-15728 Radotinib 99.19% Yes

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-13024 Rebastinib 99.84% Phase 2
HY-137460 Vodobatinib Inhibitor 98.09% Phase 2
HY-148794 Risvodetinib Inhibitor 99.21% Phase 2
HY-13072 Cenisertib Inhibitor 99.86% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125845 (S,R,S)-AHPC 99.13% Unkown
HY-125834 GMB-475 98.69% Unkown
HY-148061 DB1113 99.86% Unkown
HY-103032 Multi-kinase inhibitor 1 Inhibitor 99.05% Unkown
HY-148063 DB0614 96.07% Unkown
HY-153996 CT1113 99.61% Unkown
HY-W143698 PDGFRα kinase inhibitor 2 Inhibitor 98.95% Unkown
HY-145887 BCR-ABL1-IN-1 99.82% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-12338 ON 146040 Inhibitor 95.05% Unkown
HY-130297 PROTAC BCR-ABL1 ligand 1 Inhibitor 99.17% Unkown
HY-13072R Cenisertib (Standard) Inhibitor 99.87% Unkown
HY-110402 (S,R,S)-AHPC TFA / Unkown
HY-107447S N-Deshydroxyethyl Dasatinib-d8 / Unkown
HY-101268 CHMFL-ABL-053 Inhibitor / Unkown
HY-101763B (S,R,S)-AHPC dihydrochloride / Unkown
HY-119177 PD173956 Inhibitor / Unkown
HY-14979 ML786 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-155112 Antiproliferative agent-30 Inhibitor / Unkown
HY-15728S Radotinib-d6 / Unkown
HY-161445 (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH / Unkown
HY-162489 Tyrosine kinase-IN-8 Inhibitor / Unkown
HY-162952 cSRC/BCR-ABL1-IN-1 Inhibitor / Unkown
HY-171146 HSN748 Inhibitor / Unkown
HY-175281 SJ11646 / Unkown
HY-179247 BCR-ABL1-IN-2 Inhibitor / Unkown
HY-179460 Radotinib dihydrochloride / Unkown
HY-181839 DDR1/2 IN-4 Inhibitor / Unkown
HY-182792 Embibatinib Inhibitor / Unkown
HY-185227 EphB4-IN-1 Inhibitor / Unkown
HY-18819 BCR-ABL-IN-2 Inhibitor / Unkown
HY-E70634 ABL1 E255K Recombinant Human Active Protein Kinase / Unkown
HY-E70635 ABL1 F317I Recombinant Human Active Protein Kinase / Unkown
HY-E70636 ABL1 G250E Recombinant Human Active Protein Kinase / Unkown
HY-E70637 ABL1 H396P Recombinant Human Active Protein Kinase / Unkown
HY-E70638 ABL1 M351T Recombinant Human Active Protein Kinase / Unkown
HY-E70639 ABL1 Q252H Recombinant Human Active Protein Kinase / Unkown
HY-E70640 ABL1 T315I Recombinant Human Active Protein Kinase / Unkown
HY-E70641 ABL1 Y253F Recombinant Human Active Protein Kinase / Unkown
HY-RS00102 ABL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00103 Abl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00104 ABL1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13072B Cenisertib benzoate Inhibitor / Unkown
HY-14142 AP-24226 Inhibitor / Unkown
HY-181046 Multi-kinase-IN-14 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ABL1 NCBI NCBI:25