Fasn - fatty acid synthase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50671

About Fasn

Primary_assembly 10: 106,072,091-106,090,261 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 20 phenotypes. Biased expression in Adrenal (RPKM 37.2), Thymus (RPKM 361.4) and 5 other tissues.

Summary

Enables [acyl-carrier-protein] S-malonyltransferase activity and identical protein binding activity. Involved in acetyl-CoA metabolic process and fatty acid biosynthetic process. Located in cytoplasm. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]

Fasn Products (1)

mRNA Protein Name
NM_017332.2 NP_059028.2 fatty acid synthase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables [acyl-carrier-protein] S-malonyltransferase activity IMP
IMP: Inferred from mutant phenotype
8940200 RGD
enables fatty acid synthase activity IDA
IDA: Inferred from direct assay
15715522 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9047334 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16054098 RGD
Biological Process GO Annotation Evidence References Source
involved in acetyl-CoA metabolic process IDA
IDA: Inferred from direct assay
18062843 RGD
involved in fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
15715522 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
26394137 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25943649 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16054098 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fasn Protein Structure

PksD

PksD: COG3321 (0 - 1014)

PKS

PKS: cd00833 (1 - 403)

Methyltransf_12

Methyltransf_12: pfam08242 (1237 - 1336)

KR_1_FAS_SDR_x

KR_1_FAS_SDR_x: cd08954 (1310 - 1514)

PKS_ER

PKS_ER: smart00829 (1557 - 1847)

KR_1_FAS_SDR_x

KR_1_FAS_SDR_x: cd08954 (1869 - 2105)

entF

entF: cl35902 (2120 - 2317)

Thioesterase

Thioesterase: pfam00975 (2235 - 2494)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2505 a.a.
Protein Preferred Names Protein Names

fatty acid synthase

  • type I FAS

Fasn Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fasn P12785 Fasn Rattus norvegicus P12785
EM
15711565
Intra
Fasn P12785 Fasn Rattus norvegicus P12785
Crosslink
10206962
Intra
Fasn P12785 Fasn Rattus norvegicus P12785
Y2H
11248039
Intra
Fasn P12785 Fasn Rattus norvegicus P12785
Biochemical
11248039
Intra
Fasn P12785 Fasn Rattus norvegicus P12785
GMS
9047334
Intra
Fasn P12785 Fasn Rattus norvegicus P12785
3D-EM
19151726
Intra
Fasn P12785 Fasn Rattus norvegicus P12785
Biochemical
9047334
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0218 Orlistat 99.95% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112829 Denifanstat Inhibitor 99.58% Phase 3

Pre-clinical Phase

Bioactive Molecules (45)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12364 C75 99.91% Unkown
HY-A0210 Cerulenin ≥99.0% Unkown
HY-120394 TVB-3166 99.69% Unkown
HY-120062 TVB-3664 Inhibitor 99.76% Unkown
HY-12325 GSK2194069 Inhibitor 99.80% Unkown
HY-16100 BI 99179 Inhibitor 99.38% Unkown
HY-124628 IPI-9119 Inhibitor 98.91% Unkown
HY-121250 Fasnall 99.94% Unkown
HY-N3415 Kumatakenin 99.31% Unkown
HY-12364A trans-C75 Inhibitor 99.79% Unkown
HY-B0218R Orlistat (Standard) 98.21% Unkown
HY-111551 FT113 Inhibitor 99.39% Unkown
HY-116568 Prothioconazole 99.52% Unkown
HY-N2486 Desoxyrhaponticin 99.80% Unkown
HY-12648A FASN-IN-4 tosylate Inhibitor 98.55% Unkown
HY-110354 UCM05 Inhibitor 99.22% Unkown
HY-111777 FASN-IN-1 Inhibitor 99.69% Unkown
HY-N1399 Androsin 99.94% Unkown
HY-145809 FASN-IN-5 Inhibitor 99.98% Unkown
HY-117769 GSK837149A Inhibitor 99.13% Unkown
HY-B0218S Orlistat-d3 99.9% Unkown
HY-N12124 Monascuspiloin 95% Unkown
HY-12648 FASN-IN-4 Inhibitor 99.21% Unkown
HY-N8144 Niga-ichigoside F1 99.0% Unkown
HY-RS04753 FASN Human Pre-designed siRNA Set A / Unkown
HY-RS04754 Fasn Mouse Pre-designed siRNA Set A / Unkown
HY-RS04755 Fasn Rat Pre-designed siRNA Set A / Unkown
HY-U00436 FASN-IN-3 Inhibitor 98.06% Unkown
HY-W587772 Mono(2-ethyl-5-hydroxyhexyl) terephthalate 98.27% Unkown
HY-110354R UCM05 (Standard) Inhibitor / Unkown
HY-112522 HS79 Inhibitor / Unkown
HY-112522A HS80 Inhibitor / Unkown
HY-12364B (−)-C75 / Unkown
HY-149540 CTL-06 Inhibitor / Unkown
HY-149541 CTL-12 Inhibitor / Unkown
HY-155282 FASN-IN-6 Inhibitor / Unkown
HY-158649 Fasnall benzenesulfonate / Unkown
HY-15957 FASN-IN-7 Inhibitor / Unkown
HY-170570 PFM046 / Unkown
HY-175020 QNX-10 / Unkown
HY-176274 FASN/SCD-IN-1 / Unkown
HY-181801 FASN-IN-8 / Unkown
HY-182750 ACLY-IN-3 Inhibitor / Unkown
HY-182751 ACLY-IN-4 Inhibitor / Unkown
HY-N17737 Floramanoside F / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fasn NCBI NCBI:2194