2. Gene
  3. Fasn - fatty acid synthase Gene

Fasn - fatty acid synthase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 50671 | Gene type: protein coding

About Fasn

Primary_assembly 10: 106,072,091-106,090,261 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 20 phenotypes. Biased expression in Adrenal (RPKM 37.2), Thymus (RPKM 361.4) and 5 other tissues.

Summary

Enables [acyl-carrier-protein] S-malonyltransferase activity and identical protein binding activity. Involved in acetyl-CoA metabolic process and fatty acid biosynthetic process. Located in cytoplasm. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]

Fasn Products(1)

mRNA Protein Name
NM_017332.2 NP_059028.2 fatty acid synthase

Fasn Protein Structure

PksD

PksD: COG3321 (0 - 1014)

PKS

PKS: cd00833 (1 - 403)

Methyltransf_12

Methyltransf_12: pfam08242 (1237 - 1336)

KR_1_FAS_SDR_x

KR_1_FAS_SDR_x: cd08954 (1310 - 1514)

PKS_ER

PKS_ER: smart00829 (1557 - 1847)

KR_1_FAS_SDR_x

KR_1_FAS_SDR_x: cd08954 (1869 - 2105)

entF

entF: cl35902 (2120 - 2317)

Thioesterase

Thioesterase: pfam00975 (2235 - 2494)

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  • 2505 a.a.
Protein Preferred Names Protein Names

fatty acid synthase

type I FAS

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0218 Orlistat 98.42% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112829 Denifanstat Inhibitor 99.69% Phase 3
Pre-clinical Phase
Bioactive Molecules (29)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12364 C75 Inhibitor 99.91% Unkown
HY-120394 TVB-3166 99.76% Unkown
HY-A0210 Cerulenin 99.52% Unkown
HY-12325 GSK2194069 Inhibitor 99.84% Unkown
HY-120062 TVB-3664 Inhibitor 99.57% Unkown
HY-12364A trans-C75 Inhibitor 99.73% Unkown
HY-124628 IPI-9119 Inhibitor 99.24% Unkown
HY-16100 BI 99179 Inhibitor 99.78% Unkown
HY-111551 FT113 Inhibitor 99.61% Unkown
HY-12648A FASN-IN-4 tosylate Inhibitor 99.84% Unkown
HY-N2486 Desoxyrhaponticin 99.80% Unkown
HY-121250 Fasnall ≥98.0% Unkown
HY-110354 UCM05 Inhibitor 99.58% Unkown
HY-12648 FASN-IN-4 Inhibitor 99.21% Unkown
HY-111777 FASN-IN-1 Inhibitor 99.90% Unkown
HY-117769 GSK837149A Inhibitor ≥99.0% Unkown
HY-B0218R Orlistat (Standard) 99.85% Unkown
HY-RS04754 Fasn Mouse Pre-designed siRNA Set A / Unkown
HY-112522 HS79 Inhibitor / Unkown
HY-112522A HS80 Inhibitor / Unkown
HY-12364B (−)-C75 Inhibitor / Unkown
HY-145809 FASN-IN-5 Inhibitor 99.81% Unkown
HY-149540 CTL-06 Inhibitor / Unkown
HY-149541 CTL-12 Inhibitor / Unkown
HY-155282 FASN-IN-6 Inhibitor / Unkown
HY-N8144 Niga-ichigoside F1 ≥99.0% Unkown
HY-RS04753 FASN Human Pre-designed siRNA Set A / Unkown
HY-RS04755 Fasn Rat Pre-designed siRNA Set A / Unkown
HY-U00436 FASN-IN-3 Inhibitor 98.17% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fasn NCBI NCBI:2194