Fgf2 - fibroblast growth factor 2 Gene

Also Known as bFGF; Fgf-2; Fgf2a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54250

Summary

Enables Fibroblast Growth Factor receptor binding activity. Involved in several processes, including angiogenesis involved in coronary vascular morphogenesis; paracrine signaling; and positive regulation of cell population proliferation. Acts upstream of or within Fibroblast Growth Factor receptor signaling pathway. Located in cytoplasm; extracellular space; and nucleus. Used to study pulmonary hypertension. Biomarker of bladder disease; decubitus ulcer; diabetic retinopathy; hypertension; and retinal vein occlusion. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (Fibroblast Growth Factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgf2 Products (1)

mRNA Protein Name
NM_019305.2 NP_062178.1 fibroblast growth factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables H3K9me3 modified histone binding IDA
IDA: Inferred from direct assay
25071177 RGD
enables fibroblast growth factor receptor binding IPI
IPI: Inferred from physical interaction
10766846 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12397076 RGD
Biological Process GO Annotation Evidence References Source
involved in angiogenesis involved in coronary vascular morphogenesis IMP
IMP: Inferred from mutant phenotype
11397779 RGD
involved in behavioral response to ethanol IMP
IMP: Inferred from mutant phenotype
28821667 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19012730 RGD
involved in embryo development ending in birth or egg hatching IMP
IMP: Inferred from mutant phenotype
19476451 RGD
acts upstream of or within fibroblast growth factor receptor signaling pathway IPI
IPI: Inferred from physical interaction
10766846 RGD
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
25426952 RGD
involved in paracrine signaling IDA
IDA: Inferred from direct assay
28679962 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
19952283 RGD
involved in positive regulation of cardiac muscle cell proliferation IDA
IDA: Inferred from direct assay
8603495 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12000311 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
9854551 RGD
involved in response to ethanol IMP
IMP: Inferred from mutant phenotype
28821667 RGD
involved in response to wortmannin IMP
IMP: Inferred from mutant phenotype
31375540 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
21543745 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 2

  • HBGF-2

  • angiogenesis promoting growth factor

  • basic fibroblast growth factor

  • fibroblast growth factor 2a

  • heparin binding growth factor

  • heparin-binding growth factor 2

Recombinant Fgf2 Proteins

Cat. No. Product Name Accession Purity
HY-P7091 FGF-2 Protein, Rat P13109 (A11-S154) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-15472 PRX-08066 97.46% Phase 2
HY-177668A Umedaptanib pegol sodium Inhibitor / Phase 2
HY-177668 Umedaptanib pegol Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122704A Surfen dihydrochloride Inhibitor 99.93% Unkown
HY-D0889 Glycylglycine 99.90% Unkown
HY-107753 XRP44X Inhibitor 98.09% Unkown
HY-P1408 Obtustatin 99.94% Unkown
HY-107194 NSC12 / Unkown
HY-102071 KIN59 Inhibitor 99.0% Unkown
HY-172443 Keratin sulfate 84.2% Unkown
HY-D0889R Glycylglycine (Standard) 99.91% Unkown
HY-RS04896 FGF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-10321G PD173074 (GMP) Inhibitor / Unkown
HY-111289 Tec-IN-14 Inhibitor / Unkown
HY-116030 JNJ-26076713 Antagonist / Unkown
HY-118792 AHR activator 1 / Unkown
HY-122704 Surfen Inhibitor / Unkown
HY-123541 Tec-IN-6 Inhibitor / Unkown
HY-124827 Tec-IN-1 Inhibitor / Unkown
HY-15472A PRX-08066 maleate / Unkown
HY-161840 Antitumor agent-176 Inhibitor / Unkown
HY-161841 Antitumor agent-177 Inhibitor / Unkown
HY-175076 Globotriaosylceramide (non-hydroxy) (porcine RBC) / Unkown
HY-P10301 CXCL9(74-103) / Unkown
HY-P10870 Pep1-DNP conjugate 9 / Unkown
HY-P3335 SU015 Antagonist / Unkown
HY-RS04890 FGF13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118184 AF3485 Inhibitor / Unkown
HY-123453 SM27 Inhibitor / Unkown
HY-138257A (R)-Indeloxazine benzenesulfonate Inhibitor / Unkown
HY-165603 Si5-N14 Inhibitor / Unkown
HY-174702 Human FGF2 mRNA / Unkown
HY-RS16510 Fgf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22942 Fgf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W040074 Glycylglycine hydrochloride hydrate / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991584 HuGAL-FR21 Inhibitor 97.80% Unkown
HY-P992201 Anti-CD160 Antibody (MAT 302) / Unkown
HY-P990597 HuGAL-F2 Inhibitor 98.30% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf2 NCBI NCBI:2247