2. Gene
  3. Pde3a - phosphodiesterase 3A, cGMP inhibited Gene

Pde3a - phosphodiesterase 3A, cGMP inhibited Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as A930022O17Rik

Gene ID: 54611 | Gene type: protein coding

About Pde3a

Chromosome 6: 141,194,995-141,453,174 forward strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 258 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in lung adult (RPKM 3.5), heart adult (RPKM 3.3) and 24 other tissues.

Summary

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including oocyte maturation; positive regulation of oocyte development; and regulation of meiotic nuclear division. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in hypertension and brachydactyly syndrome. Orthologous to human PDE3A (phosphodiesterase 3A). [provided by Alliance of Genome Resources, Apr 2022]

Pde3a Products(1)

mRNA Protein Name
NM_018779.2 NP_061249.1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

Pde3a Protein Structure

PDEase_I

PDEase_I: pfam00233 (750 - 1011)

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  • 1141 a.a.
Protein Preferred Names Protein Names

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

cGMP-inhibited 3',5'-cyclic phosphodiesterase A

CGI-PDE A

cGMP-inhibited phosphodiesterase

cyclic GMP-inhibited phosphodiesterase A

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-U00186 K134 Inhibitor 99.81% Phase 2
HY-145924 BAY 2666605 Inhibitor 99.64% Phase 1
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101312 Cilostamide 99.64% Unkown
HY-W028690 DNMDP Inhibitor 98.95% Unkown
HY-100530C Sp-cAMPS sodium salt 98.73% Unkown
HY-136350 BRD9500 Modulator 99.46% Unkown
HY-100530B Sp-cAMPS / Unkown
HY-122751 (R)-DNMDP Inhibitor 99.64% Unkown
HY-110005 Sp-cAMPS triethylamine / Unkown
HY-136350B (S)-BRD9500 99.22% Unkown
HY-153802 Antitumor agent-100 Inducer / Unkown
HY-153802A Antitumor agent-100 hydrochloride Inducer / Unkown
HY-N10149 Nauclefine / Unkown
HY-N11965 4'-Methoxyisoagarotetrol Inhibitor / Unkown
HY-RS10216 PDE3A Human Pre-designed siRNA Set A / Unkown
HY-RS10217 Pde3a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10218 Pde3a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde3a NCBI NCBI:5139