Sirt3 - sirtuin 3 Gene

Also Known as Sir2l3; 2310003L23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64384

About Sirt3

Chromosome 7: 140,443,579-140,462,222 reverse strand.GRCm39:CM001000.3

This gene has 10 transcripts (splice variants), 198 orthologues, 6 paralogues and is associated with 36 phenotypes. Ubiquitous expression in kidney adult (RPKM 35.3), liver adult (RPKM 33.7) and 28 other tissues.

Summary

Enables NAD-dependent histone deacetylase activity (H3-K14 specific) and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation and protein deacetylation. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (Sirtuin 3). [provided by Alliance of Genome Resources, Apr 2022]

Sirt3 Products (3)

mRNA Protein Name
NM_022433.2 NP_071878.2 NAD-dependent protein deacetylase sirtuin-3 isoform 1
NM_001177804.1 NP_001171275.1 NAD-dependent protein deacetylase sirtuin-3 isoform 3
NM_001127351.1 NP_001120823.1 NAD-dependent protein deacetylase sirtuin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
16790548 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21720390 MGI
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
21858060 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23283301 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of peptidyl-lysine acetylation IDA
IDA: Inferred from direct assay
17923681 MGI
acts upstream of or within negative regulation of peptidyl-lysine acetylation IMP
IMP: Inferred from mutant phenotype
17923681 MGI
involved in peptidyl-lysine deacetylation IDA
IDA: Inferred from direct assay
26620563 MGI
involved in positive regulation of ceramide biosynthetic process IDA
IDA: Inferred from direct assay
26620563 MGI
involved in positive regulation of mitochondrial transcription IMP
IMP: Inferred from mutant phenotype
23283301 MGI
acts upstream of or within protein deacetylation IMP
IMP: Inferred from mutant phenotype
23576753 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
11056054 MGI
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
18054327 MGI
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
17923681 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
17923681 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
23283301 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt3 Protein Structure

SIRT1

SIRT1: cd01408 (0 - 230)

  • 0
  • 100
  • 200
  • 257 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacetylase sirtuin-3

  • NAD-dependent deacetylase sirtuin-3

  • SIR2-like protein 3

  • SIRT3L mitochondrial

  • mSIR2L3

  • mitochondrial protein lysine deacetylase

  • regulatory protein SIR2 homolog 3

  • silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3

Sirt3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sirt3 Q8R104 Aldh2 Mus musculus P47738
Anti Bait CoIP
21720390
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0130 Perindopril 99.85% Yes
HY-B0130A Perindopril erbumine 99.98% Yes

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-123033A Nicotinamide riboside chloride Activator 99.90% Phase 4
HY-123033C Nicotinamide riboside malate Activator 98.04% Phase 4
HY-123033B Nicotinamide riboside tartrate Activator 98.07% Phase 4
HY-123033 Nicotinamide riboside Activator / Phase 4

Pre-clinical Phase

Bioactive Molecules (36)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108331 3-TYP Inhibitor 99.90% Unkown
HY-113402 Gamma-glutamylcysteine Activator 98.53% Unkown
HY-100578 AGK2 Inhibitor 99.43% Unkown
HY-158426 2-APQC Agonist 99.70% Unkown
HY-15510 Tenovin-6 Inhibitor 98.00% Unkown
HY-N1511 Ganoderic acid D Activator 99.89% Unkown
HY-N2110 Phellopterin Agonist 99.94% Unkown
HY-119575 Tetramethyluric acid Activator 99.63% Unkown
HY-16616 SIRT-IN-2 Inhibitor 98.08% Unkown
HY-136199 SIRT1-IN-1 Inhibitor 98.15% Unkown
HY-N2673 5-Heptadecylresorcinol Activator 99.83% Unkown
HY-16605 SIRT6-IN-6 Inhibitor 98.59% Unkown
HY-163987 SIRT3 activator 2 Activator 98.94% Unkown
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% Unkown
HY-173572 SKLB-11A Agonist 99.40% Unkown
HY-161920 SIRT3-IN-1 Inhibitor 98.47% Unkown
HY-124113 4'-Bromo-resveratrol Inhibitor 99.94% Unkown
HY-16615 SIRT-IN-1 Inhibitor 98.14% Unkown
HY-111329 JGB1741 Inhibitor 99.37% Unkown
HY-19339 Tenovin-3 Degrader 98.0% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor 98.37% Unkown
HY-136855 MitoPBN Modulator 95.00% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-151519 SIRT2-IN-9 Inhibitor 99.45% Unkown
HY-118343 AC-93253 Inhibitor 99.3% Unkown
HY-111303 CHIC35 Inhibitor / Unkown
HY-155784 SPC-180002 Inhibitor / Unkown
HY-170402 SIRT6-IN-4 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-146013 Sirt1/2-IN-1 Inhibitor / Unkown
HY-114906 SIRT1/2/3-IN-2 Inhibitor / Unkown
HY-160944 hsa62 Inhibitor / Unkown
HY-160617 SIRT2-IN-14 Inhibitor / Unkown
HY-184173 OXPHOS-IN-3 Inhibitor / Unkown
HY-118109 SIRT3-IN-2 Inhibitor / Unkown
HY-W109401 SIRT-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt3 NCBI NCBI:23410