GW405833 hydrochloride (Synonyms: L768242 hydrochloride)

Cat. No.: HY-110036A Purity: 99.59%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

GW405833 hydrochloride is a potent and selective cannabinoid-2 (CB2) receptor agonist (EC₅₀ = 0.65 nM; maximum inhibition = 44.6%). GW405833 hydrochloride produces potent antihyperalgesic effects in several rodent models of pain.

For research use only. We do not sell to patients.

GW405833 hydrochloride Chemical Structure

CAS No. : 1202865-22-2

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 670	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Other Forms of GW405833 hydrochloride:

GW-405833 In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

483.82

Formula

C₂₃H₂₅Cl₃N₂O₃

CAS No.

1202865-22-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C(Cl)=CC=C1)Cl)N2C3=C(C=C(OC)C=C3)C(CCN4CCOCC4)=C2C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (258.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0669 mL	10.3344 mL	20.6688 mL
5 mM	0.4134 mL	2.0669 mL	4.1338 mL
10 mM	0.2067 mL	1.0334 mL	2.0669 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.59%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (251 KB) HNMR (290 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Li AL, Carey LM, Mackie K, Hohmann AG. Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice. J Pharmacol Exp Ther. 2017;362(2):296-305. [Content Brief]

[2]. Parlar A, Arslan SO, Doğan MF, et al. The exogenous administration of CB2 specific agonist, GW405833, inhibits inflammation by reducing cytokine production and oxidative stress. Exp Ther Med. 2018;16(6):4900-4908. [Content Brief]

[3]. Marini P, Cascio MG, King A, Pertwee RG, Ross RA. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. Br J Pharmacol. 2013;169(4):887-899. [Content Brief]

[4]. Brownjohn PW, Ashton JC. Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury. Neuroscience. 2012;203:180-193. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0669 mL	10.3344 mL	20.6688 mL	51.6721 mL
	5 mM	0.4134 mL	2.0669 mL	4.1338 mL	10.3344 mL
	10 mM	0.2067 mL	1.0334 mL	2.0669 mL	5.1672 mL
	15 mM	0.1378 mL	0.6890 mL	1.3779 mL	3.4448 mL
	20 mM	0.1033 mL	0.5167 mL	1.0334 mL	2.5836 mL
	25 mM	0.0827 mL	0.4134 mL	0.8268 mL	2.0669 mL
	30 mM	0.0689 mL	0.3445 mL	0.6890 mL	1.7224 mL
	40 mM	0.0517 mL	0.2584 mL	0.5167 mL	1.2918 mL
	50 mM	0.0413 mL	0.2067 mL	0.4134 mL	1.0334 mL
	60 mM	0.0344 mL	0.1722 mL	0.3445 mL	0.8612 mL
	80 mM	0.0258 mL	0.1292 mL	0.2584 mL	0.6459 mL
	100 mM	0.0207 mL	0.1033 mL	0.2067 mL	0.5167 mL

GW405833 hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW4058331202865-22-2L768242GW 405833GW-405833L 768242L-768242Cannabinoid ReceptorCB2 receptor agonistInhibitorinhibitorinhibit

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