HDAC2-IN-4
HDAC2-IN-4 is a HDAC2 inhibitor with an IC50 of 4.2 nM against human HDAC2. HDAC2-IN-4 binds to the active site of HDAC2 via hydrogen bonding and hydrophobic interactions, forming a thermodynamically stable and kinetically compatible protein-ligand complex to inhibit enzymatic activity. HDAC2-IN-4 inhibits cancer cell proliferation and exhibits low toxicity to normal cells. HDAC2-IN-4 can be used in studies related to human endocervical adenocarcinoma and Burkitt lymphoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C19H28N2O5
- 分子量:364.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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hHDAC2 4.2 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
5.07 μM
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Antiproliferative activity against human endocervical adenocarcinoma HeLa cells assessed by resazurin assay after 72 h incubation with the compound followed by 3 h resazurin incubation.
Antiproliferative activity against human endocervical adenocarcinoma HeLa cells assessed by resazurin assay after 72 h incubation with the compound followed by 3 h resazurin incubation.
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42520173 |
| Raji | IC50 |
1.87 μM
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Antiproliferative activity against human Burkitt's lymphoma Raji cells assessed by resazurin assay after 72 h incubation with the compound followed by 3 h resazurin incubation.
Antiproliferative activity against human Burkitt's lymphoma Raji cells assessed by resazurin assay after 72 h incubation with the compound followed by 3 h resazurin incubation.
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42520173 |
HDAC2-IN-4 (23e) (0.1-100 μM; 1 h) potently inhibits purified human HDAC2 protein, with an IC50 of 4.2 nM[1].
HDAC2-IN-4 (500 ns) forms a thermodynamically stable and kinetically compatible complex with human HDAC2 protein[1].
HDAC2-IN-4 (0.1-250 μM; 72 h) potently inhibits the proliferation of HeLa and Raji cancer cells, with IC50 values of 5.07 μM and 1.87 μM, respectively, while exhibiting low toxicity toward non-cancerous Hek293T and DF cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human endocervical adenocarcinoma (HeLa) cells, human Burkitt's lymphoma (Raji) cells, human embryonic kidney (Hek293T) non-cancer cells, primary human dermal fibroblasts (DF) non-cancer cells
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Concentration:0.1, 1, 10, 50 and 250 μM
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Incubation Time:72 h
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Result:Exhibited pronounced antiproliferative activity against HeLa cells with an IC50 of 5.07 μM.
Exhibited pronounced antiproliferative activity against Raji cells with an IC50 of 1.87 μM.
Showed low toxicity against non-cancer Hek293T and DF cells, demonstrating selective cytotoxicity toward malignant cells.
化学情報
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分子量 364.44
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分子式 C19H28N2O5
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SMILES
O=C(OCCCC)C1=CC=C(NC(CCCCCCC(NO)=O)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HDAC2-IN-4 関連分類
HY-187813 関連分類
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