HSP70-IN-7
HSP70-IN-7 is a nonselective HSP70 inhibitor with Kds of 4.71, 2.16 and 2.93μM against HSP70, GRP75, and GRP78. HSP70-IN-7 exhibits selective toxicity against breast cancer cells, induces cell apoptosis and effectively suppresses the properties of breast cancer stem cells (BCSCs). HSP70-IN-7 can be used for the study of breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C55H66BrN4O2PS
- 分子量:958.08
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
Grp78 2.93 μM (Ki) |
HSP70 4.71 μM (Ki) |
体外実験
HSP70-IN-7 (compound 5) (48 h) inhibits breast cancer cells proliferation with IC50 values of 0.793, 0.297, 0.863 and 0.6 μM against MDA-MB-231, BT549, MCF7 and CAMA1 cells[1].
HSP70-IN-7 (1 μM, 48 h) induces apoptosis in stable clones from NS/GRP75 shRNA-transfected BT549 cells[1].
HSP70-IN-7 (0.5-1 μM, 10-14 d) inhibits the colony formation and mammosphere formation of MDA-MB-231 cells[1].
HSP70-IN-7 (1 μM, 0-1 h) directly acts on mitochondrial GRP75, destroying its PPIs, thereby leading to mitochondrial membrane permeabilization and Cyt c release in BT549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BT549 cells
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Concentration:1 μM
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Incubation Time:48 h
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Result:Induced cell apoptosis.
化学情報
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分子量 958.08
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分子式 C55H66BrN4O2PS
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SMILES
CN(CCNC(C1=C2C3=CC=CC2=C(C=C1)SC4CCCCC4)=C(C3=O)C#N)CCNC(CCCCCCCCCCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O.[Br-]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HSP70-IN-7 関連分類
HY-175865 関連分類
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