HSP70-IN-7
HSP70-IN-7 is a nonselective HSP70 inhibitor with Kds of 4.71, 2.16 and 2.93μM against HSP70, GRP75, and GRP78. HSP70-IN-7 exhibits selective toxicity against breast cancer cells, induces cell apoptosis and effectively suppresses the properties of breast cancer stem cells (BCSCs). HSP70-IN-7 can be used for the study of breast cancer.
For research use only. We do not sell to patients.
- Formula: C55H66BrN4O2PS
- Molecular Weight:958.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Grp78 2.93 μM (Ki) |
HSP70 4.71 μM (Ki) |
HSP70-IN-7 (compound 5) (48 h) inhibits breast cancer cells proliferation with IC50 values of 0.793, 0.297, 0.863 and 0.6 μM against MDA-MB-231, BT549, MCF7 and CAMA1 cells[1].
HSP70-IN-7 (1 μM, 48 h) induces apoptosis in stable clones from NS/GRP75 shRNA-transfected BT549 cells[1].
HSP70-IN-7 (0.5-1 μM, 10-14 d) inhibits the colony formation and mammosphere formation of MDA-MB-231 cells[1].
HSP70-IN-7 (1 μM, 0-1 h) directly acts on mitochondrial GRP75, destroying its PPIs, thereby leading to mitochondrial membrane permeabilization and Cyt c release in BT549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BT549 cells
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Concentration:1 μM
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Incubation Time:48 h
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Result:Induced cell apoptosis.
Chemical Information
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Molecular Weight 958.08
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Formula C55H66BrN4O2PS
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SMILES
CN(CCNC(C1=C2C3=CC=CC2=C(C=C1)SC4CCCCC4)=C(C3=O)C#N)CCNC(CCCCCCCCCCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O.[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HSP70-IN-7 Related Classifications
HY-175865 Related Classifications
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