HSP90-IN-29
HSP90-IN-29 (Compound 13), a benzoxazole derivative, is a potent and selective HSP-90 inhibitor with an IC50 value of 30 nM. HSP90-IN-29 has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 1012788-65-6
- Formula: C19H20ClN3O4
- Molecular Weight:389.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
HSP90 30 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
0.29 μM
Compound: 13
|
Antiproliferation activity against human DU145 cells
Antiproliferation activity against human DU145 cells
|
[PMID: 18197612] |
| HCT-116 | IC50 |
0.05 μM
Compound: 13
|
Antiproliferation activity against human HCT116 cells in presence of geldanamycin
Antiproliferation activity against human HCT116 cells in presence of geldanamycin
|
[PMID: 18197612] |
| HCT-116 | IC50 |
0.28 μM
Compound: 13
|
Antiproliferation activity against human HCT116 cells
Antiproliferation activity against human HCT116 cells
|
[PMID: 18197612] |
| LNCaP | IC50 |
0.17 μM
Compound: 13
|
Antiproliferation activity against human LnCap cells
Antiproliferation activity against human LnCap cells
|
[PMID: 18197612] |
| LNCaP | IC50 |
0.33 μM
Compound: 13
|
Androgen receptor degradation in human LnCAP cells
Androgen receptor degradation in human LnCAP cells
|
[PMID: 18197612] |
| SK-BR-3 | IC50 |
0.33 μM
Compound: 13
|
Degradation of HER2 in human SKBR3 cells
Degradation of HER2 in human SKBR3 cells
|
[PMID: 18197612] |
| SK-BR-3 | IC50 |
0.37 μM
Compound: 13
|
Antiproliferation activity against human SKBR3 cells
Antiproliferation activity against human SKBR3 cells
|
[PMID: 18197612] |
Chemical Information
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CAS No. 1012788-65-6
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Molecular Weight 389.83
-
Formula C19H20ClN3O4
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SMILES
ClC1=CC(C2=NOC3=C2C=C(NCCN4CCOCC4)C=C3)=C(C=C1O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)