TIK-301
TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment.
For research use only. We do not sell to patients.
- CAS No.: 118702-11-7
- Formula: C14H17ClN2O2
- Molecular Weight:280.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
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MT1 0.081 nM (Ki) |
MT2 0.042 nM (Ki) |
5-HT2C Receptor |
5-HT2B Receptor |
The Tmax and half-life of TIK-301 is 1.1 hour and 1 hour, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 118702-11-7
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Molecular Weight 280.75
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Formula C14H17ClN2O2
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SMILES
CC(NC[C@@H](C1=CNC2=C1C=C(OC)C(Cl)=C2)C)=O
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Synonyms
PD-6735; LY-156735
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Paulis L, et al. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs. 2012 Nov;21(11):1661-78. [Content Brief]
[2]. Rivara S, et al. Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8(11):954-68. [Content Brief]
[3]. Carocci A, et al. Melatonergic drugs in development. Clin Pharmacol. 2014 Sep 18;6:127-37. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TIK-301 Related Classifications
HY-106136 Related Classifications
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