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TTFB

(Synonyms: N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide)
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TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel (ZAC) antagonist. TTFB inhibits Zn2+- and H+-induced ZAC currents with IC50 values of 3 μM and 8.5 μM, respectively, and has an IC50 of 4.7 μM against spontaneous activity. TTFB shows no significant agonistic, antagonistic or modulatory activity towards representative classical Cys-loop receptors including m5-HT3AR, hα3β4 nAChR, hα1β2γ2S GABAAR and hα1 GlyR. TTFB can be used to investigate the physiological and pathological functions of ZAC.

For research use only. We do not sell to patients.

  • Purity: 99.83%
  • CAS No.: 352560-76-0
  • Formula: C14H15FN2OS
  • Molecular Weight:278.35
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • TTFB Chemical Structure
    TTFB Chemical Structure
CAS No.: 352560-76-0
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • TTFB Chemical Structure
    TTFB Chemical Structure
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  • TTFB