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EHNA

5 Cited Publications
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Based on 5 publication(s) in Google Scholar

EHNA is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.

For research use only. We do not sell to patients.

  • CAS No.: 51350-19-7
  • Formula: C14H23N5O
  • Molecular Weight:277.37
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • EHNA Chemical Structure
    EHNA Chemical Structure
  • Experimental Validation Results for EHNA
  • Experimental Validation Results for EHNA
  • Experimental Validation Results for EHNA
  • Experimental Validation Results for EHNA
  • Experimental Validation Results for EHNA
CAS No.: 51350-19-7
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609-228-6898
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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All Phosphodiesterase (PDE) Isoforms

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  • EHNA Chemical Structure
    EHNA Chemical Structure
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    EHNA purchased from MedChemExpress. Usage Cited in: Biomed Chromatogr. 2025 Apr;39(4):e70038. [Abstract]

    Customer Validation
     Time-course curves of cordycepin in rat blood and brain after administration of cordycepin (10 mg/kg; i.p.) with EHNA hydrochloride (10 mg/kg; i.p.; single dose).

  • 1/16

    EHNA purchased from MedChemExpress. Usage Cited in: Biomed Chromatogr. 2025 Apr;39(4):e70038. [Abstract]

    Customer Validation
     Time-course curves of 3′-deoxyinosine in rat blood and brain after administration of cordycepin (10 mg/kg; i.p.) with or without EHNA hydrochloride (10 mg/kg; i.p.; single dose).

  • 1/16

    EHNA purchased from MedChemExpress. Usage Cited in: Front Immunol. 2022 Oct 4:13:946871. [Abstract]

    Customer Validation
     EHNA hydrochloride (100 μM; 30 min)-mediated inhibition of adenosine deaminase (ADA) impairs the proliferation of CD4+ T cells, whereas CD8+ T cell proliferation remains unaffected.

  • 1/16

    EHNA purchased from MedChemExpress. Usage Cited in: Oncoimmunology. 2022 Dec 26;12(1):2152635. [Abstract]

    Customer Validation
     Adenosine production in HCCLM3 cells. The results showed that Culture medium of siNC- and siCD38-treated HCCLM3 cells without EHNA hydrochloride (100 μM) intervention showed gradually degraded adenosine and no accumulation, with no significant difference, while upon EHNA hydrochloride, adenosine accumulated in the medium and its content was decreased in response to siCD38 at different time points (6 h, 12 h, 18 h, and 24 h).

  • 1/16

    EHNA purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2021 Jun 15:901:174077. [Abstract]

    Customer Validation
     The effects of EHNA hydrochloride (0.01, 0.1, 1, 10 μmol/L) were also presented in non-pacing and pacing modes in ex vivo isolated rat left hearts. EHNA: a classical PDE2 inhibitor. During the experiments, these different concentrations of EHNA from low to high concentration order were added to the perfusion solution and infused via retrograde perfusion of the coronary artery. The hemodynamic parameters were recorded when isolated heart contraction reached constant level with EHNA perfusions longer than 10 min for each concentration. Their intraventricular pressures were measured.

  • EHNA