KRT1 - keratin 1 Gene

Also Known as K1; CK1; EHK; AEI2; EHK1; EPPK; KRT1A; NEPPK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3848

About KRT1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,674,736-52,680,407 (from NCBI)

This gene has 2 transcripts (splice variants), 78 orthologues, 68 paralogues and is associated with 18 phenotypes. Restricted expression toward skin (RPKM 6502.3).

Summary

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

KRT1 Products (1)

mRNA	Protein	Name
NM_006121.4	NP_006112.3	keratin, type II cytoskeletal 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carbohydrate binding	IPI IPI: Inferred from physical interaction	11549596	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11290596	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	27595935	GOA
enables structural constituent of skin epidermis	IDA IDA: Inferred from direct assay	7543090	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in complement activation, lectin pathway	IPI IPI: Inferred from physical interaction	11549596	GOA
involved in peptide cross-linking	IDA IDA: Inferred from direct assay	7543090	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	27595935	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cornified envelope	IDA IDA: Inferred from direct assay	7543090	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	32179842	GOA
located in keratin filament	IPI IPI: Inferred from physical interaction	27595935	GOA
located in membrane	IDA IDA: Inferred from direct assay	11290596	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT1 Protein Structure

Filament

0
100
200
300
400
500
600
644 a.a.

Protein Preferred Names	Protein Names
keratin, type II cytoskeletal 1	67 kDa cytokeratin

KRT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT1	P04264	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	KRT1	P04264	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	KRT1	P04264	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	KRT1	P04264	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT33B	Homo sapiens	Q14525	Validated Y2H	25910212
Intra	KRT1	P04264	KRT33B	Homo sapiens	Q14525	Y2H Bait-Prey Pool	25910212
Intra	KRT1	P04264	KRT33B	Homo sapiens	Q14525	SLC	25910212
Intra	KRT1	P04264	KRT33B	Homo sapiens	Q14525	Y2H Array	25910212
Intra	KRT1	P04264	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	KRT1	P04264	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	KRT1	P04264	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	KRT1	P04264	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	KRT1	P04264	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
Intra	KRT1	P04264	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	KRT1	P04264	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	KRT1	P04264	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	KRT1	P04264	KRT39	Homo sapiens	Q6A163	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT39	Homo sapiens	Q6A163	Validated Y2H	32296183
Intra	KRT1	P04264	KRT39	Homo sapiens	Q6A163	Y2H Array	32296183
Intra	KRT1	P04264	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	KRT1	P04264	KRT25	Homo sapiens	Q7Z3Z0	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT25	Homo sapiens	Q7Z3Z0	Validated Y2H	32296183
Intra	KRT1	P04264	KRT25	Homo sapiens	Q7Z3Z0	Y2H Array	32296183
Intra	KRT1	P04264	KRT28	Homo sapiens	Q7Z3Y7	Validated Y2H	32296183
Intra	KRT1	P04264	KRT28	Homo sapiens	Q7Z3Y7	Y2H Array	32296183
Intra	KRT1	P04264	KRT28	Homo sapiens	Q7Z3Y7	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT26	Homo sapiens	Q7Z3Y9	Validated Y2H	32296183
Intra	KRT1	P04264	KRT26	Homo sapiens	Q7Z3Y9	Y2H Array	32296183
Intra	KRT1	P04264	KRT26	Homo sapiens	Q7Z3Y9	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT13	Homo sapiens	P13646	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT13	Homo sapiens	P13646	Y2H Array	32296183
Intra	KRT1	P04264	KRT13	Homo sapiens	P13646	Validated Y2H	32296183
Intra	KRT1	P04264	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	KRT1	P04264	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	KRT1	P04264	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	KRT1	P04264	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	KRT1	P04264	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	32296183
Intra	KRT1	P04264	HAUS1	Homo sapiens	Q96CS2	Y2H Array	32296183
Intra	KRT1	P04264	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	KRT1	P04264	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT24	Homo sapiens	Q2M2I5	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT24	Homo sapiens	Q2M2I5	Validated Y2H	32296183
Intra	KRT1	P04264	KRT24	Homo sapiens	Q2M2I5	Y2H Array	32296183
Intra	KRT1	P04264	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	KRT1	P04264	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	KRT1	P04264	NUP62	Homo sapiens	P37198	Validated Y2H	32296183
Intra	KRT1	P04264	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	NUP62	Homo sapiens	P37198	Y2H Array	25910212
Intra	KRT1	P04264	NUP62	Homo sapiens	P37198	Validated Y2H	25910212
Intra	KRT1	P04264	NUP62	Homo sapiens	P37198	Y2H Bait-Prey Pool	25910212
Intra	KRT1	P04264	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	KRT1	P04264	NUP62	Homo sapiens	P37198	SLC	25910212
Intra	KRT1	P04264	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT16	Homo sapiens	P08779	Validated Y2H	32296183
Intra	KRT1	P04264	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	KRT1	P04264	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	KRT1	P04264	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	KRT1	P04264	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25910212
Intra	KRT1	P04264	GOLGA2	Homo sapiens	Q08379	Y2H Bait-Prey Pool	25910212
Intra	KRT1	P04264	GOLGA2	Homo sapiens	Q08379	Y2H Array	25910212
Intra	KRT1	P04264	U2AF1	Homo sapiens	Q01081	Validated Y2H	32296183
Intra	KRT1	P04264	KRT14	Homo sapiens	P02533	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT14	Homo sapiens	P02533	Y2H Array	32296183
Intra	KRT1	P04264	TRIM27	Homo sapiens	P14373	Y2H Bait-Prey Pool	25910212
Intra	KRT1	P04264	TRIM27	Homo sapiens	P14373	Validated Y2H	25910212
Intra	KRT1	P04264	TRIM27	Homo sapiens	P14373	SLC	25910212
Intra	KRT1	P04264	TRIM27	Homo sapiens	P14373	Y2H Array	25910212
Intra	KRT1	P04264	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	32296183
Intra	KRT1	P04264	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	KRT1	P04264	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT15	Homo sapiens	P19012	Y2H Bait-Prey Pool	25910212
Intra	KRT1	P04264	KRT15	Homo sapiens	P19012	Y2H Array	32296183
Intra	KRT1	P04264	KRT15	Homo sapiens	P19012	SLC	25910212
Intra	KRT1	P04264	KRT15	Homo sapiens	P19012	Validated Y2H	25910212
Intra	KRT1	P04264	KRT15	Homo sapiens	P19012	Y2H Array	25910212
Intra	KRT1	P04264	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT15	Homo sapiens	P19012	Validated Y2H	32296183
Intra	KRT1	P04264	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183
Intra	KRT1	P04264	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	KRT1	P04264	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT19	Homo sapiens	P08727	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT19	Homo sapiens	P08727	Validated Y2H	32296183
Intra	KRT1	P04264	KRT19	Homo sapiens	P08727	Y2H Array	32296183
Intra	KRT1	P04264	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	KRT1	P04264	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	KRT1	P04264	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	KRT1	P04264	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	KRT1	P04264	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	KRT1	P04264	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	KRT1	P04264	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KRT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82920	Cytokeratin 1 Antibody (YA2665)	WB	Human, Mouse, Rat
HY-P85988	Cytokeratin 1 Antibody (YA5680)	IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Palmoplantar Keratoderma, Nonepidermolytic	Nonepidermolytic Palmoplantar Keratoderma NEPPK Tylosis Unna-Thost Syndrome Keratoderma, Palmoplantar, Diffuse Ppkne Keratoderma, Nonepidermolytic Palmoplantar Diffuse Nonepidermolytic Palmomplantar Keratoderma Thost-Unna Syndrome Non-Epidermolytic Palmoplantar Keratoderma Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type Diffuse Palmoplantar Keratoderma, Bothnian Type Krt1-Related Diffuse Nonepidermolytic Keratoderma Krt1-Related Diffuse Neppk Keratoderma, Palmoplantar, Non-Epidermolytic Nonepidermolytic Unna-Thost Disease Non-Epidermolytic Unna-Thost Disease Keratoderma, Palmoplantar, Nonepidermolytic Hyperkeratosis
Epidermolytic Hyperkeratosis	Bullous Congenital Ichthyosiform Erythroderma Bullous Ichthyosiform Erythroderma EHK Bullous Erythroderma Ichthyosiformis Congenita Of Brocq Bcie Bie Epidermolytic Ichthyosis Ichthyosis Bullosa Of Siemens Superficial Epidermolytic Ichthyosis Hyperkeratosis, Epidermolytic Congenital Bullous Ichthyosiform Erythroderma Bullous Type Ichthyosis Epidermolytic Palmoplantar Hyperkeratosis Bullous Ichthyosiform Erythroderma Congenita Bullous Erythroderma Ichthyosiforme Sei Epidermolytic Hyperkeratosis Late-Onset Epidermolytic Hyperkeratosis, Late-Onset
Ichthyosis Hystrix, Curth-Macklin Type	IHCM Ichthyosis Hystrix Of Curth-Macklin Ichthyosis Hystrix, Curth Macklin Type Ichthyosis Histrix, Curth-Macklin Type Curth-Macklin Type Ichthyosis Hystrix
Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis	AEI Annular Epidermolytic Ichthyosis Epidermolytic Ichthyosis, Annular Ciehk Ichthyosis Annular Epidermolytic Annular Ichthyosis Variant Of Bcie Cyclic Ichthyosis With Epidermolytic Hyperkeratosis
Keratosis Palmoplantaris Striata Iii	Keratosis Palmoplantaris Striata 3 PPKS3 Striate Palmoplantar Keratoderma Iii SPPK3 Keratoderma, Palmoplantar, Striate Form Iii Kpps3 Keratoderma Palmoplantar Striate Form 3 Striate Palmoplantar Keratoderma 3 Keratoderma, Palmoplantar, Striate 3 Keratosis Palmoplantaris Striata, Type 3
Palmoplantar Keratoderma, Epidermolytic	Epidermolytic Palmoplantar Keratoderma EPPK Keratosis Palmaris Et Plantaris Familiaris Tylosis Keratosis Of Greither Diffuse Nonepidermolytic Palmoplantar Keratoderma Keratoderma, Palmoplantar, Epidermolytic Unna-Thost Palmoplantar Keratoderma Epidermolytic Palmoplantar Keratoderma Of Voerner Ppke Keratoderma, Epidermolytic Palmoplantar Palmoplantar Keratoderma, Vorner Type Hyperkeratosis, Localized Epidermolytic Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type Epidermolytic Palmoplantar Keratoderma Of Vörner Hyperkeratosis Palmoplantar Localized Epidermolytic Diffuse Neppk Ppk Diffusa Circumscripta Thost-Unna Disease Thost-Unna Palmoplantar Keratoderma Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type Epidermolytic Palmoplantar Keratoderma Of Vorner Ehppk Epidermolytic Unna-Thost Disease Localized Epidermolytic Hyperkeratosis Palmoplantar Keratoderma Vorner Type Unilateral Palmoplantar Verrucous Nevus UPVN Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Palmoplantar Keratoderma, Nonepidermolytic Epidermolytic Palmoplantar Keratoderma Vorner Type Type B Tylosis Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Type A Tylosis
Ichthyosis With Confetti	Congenital Reticular Ichthyosiform Erythroderma IWC CRIE Erythroderma, Ichthyosiform, Congenital Reticular Ichthyosis Variegata Erythrokeratoderma, Reticular Ichthyosis Variegata Micropinnae, Alopecia Universalis, Congenital Ichthyosis, And Ectropion Mauie Mauie Syndrome Aarau Disease Reticular Erythrokeratoderma
Autosomal Dominant Epidermolytic Ichthyosis	Bcie Bullous Congenital Ichthyosiform Erythroderma Bullous Congenital Ichthyosiform Erythroderma Of Brock Bullous Ichthyosis Ehk Ei Epidermolytic Hyperkeratosis Ichthyosis Hystrix Brocq Type
Striate Palmoplantar Keratoderma	Keratosis Palmoplantaris Striata Keratosis Palmoplantaris Striata Et Areata Keratosis Palmoplantaris Varians Of Wachters
Keratoderma, Palmoplantar, With Nail Dystrophy And Hereditary Motor-Sensory Neuropathy	Axonal Neuropathy With Palmoplantar Keratoderma Charcot-Marie-Tooth Disease With Palmoplantar Keratoderma And Nail Dystrophy Keratoderma Palmoplantar Spastic Paralysis Palmoplantar Keratoderma-Spastic Paralysis Syndrome Powell-Venencie-Gordon Syndrome Palmoplantar Hyperkeratosis-Spastic Paralysis Syndrome Palmoplantar Keratoderma-Hereditary Motor And Sensory Neuropathy Syndrome Palmoplantar Keratoderma-Charcot-Marie-Tooth Syndrome Powell Venencie Gordon Syndrome
Keratosis	Actinic Keratosis Hyperkeratosis
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Epidermolysis Bullosa Simplex	Ebs Epidermolysis Bullosa Intraepidermic Epidermolytic Epidermolysis Bullosa
Palmoplantar Keratosis	Palmoplantar Keratoderma Keratosis Palmaris Et Plantaris Palmo-Plantar Keratodermas Keratoderma, Palmoplantar Keratoderma Palmoplantar Keratoderma, Palmoplantar, Diffuse Hyperkeratosis Of Palms And Soles Palmoplantar Hyperkeratosis
Ichthyosis Bullosa Of Siemens	IBS Ichthyosis, Bullous Type Bullous Type Of Ichthyosis Ichthyosis Bullous Type
Ichthyosis Vulgaris	Ichthyosis Simplex Dominant Congenital Ichthyosiform Erythroderma Common Ichthyosis Fish Scale Disease VI Ichthyoses Congenital Ichthyosis
Leukoplakia	Leukoplakia Of Gingiva Leukoplakia Of Oral Epithelium Leucoplakia Of Oral Mucosa Leukokeratosis Of Oral Mucosa
Epithelioid Sarcoma	Epithelioid Cell Sarcoma Sarcoma Epithelioid Sarcoma, Epithelioid
Epidermolytic Acanthoma
Ameloblastoma	Adenoameloblastoma
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Epidermolysis Bullosa	Acantholysis Bullosa Eb
Syringoma	Syringomas
Lichen Planus	Lichen Ruber Planus Lichen, Ruber Planus Ruber Planus Lp - [Lichen Planus] Lichen Planus Of Wilson Wilson Lichen Ruber
Skin Benign Neoplasm	Neoplasm Of Skin By Site Tumor Of The Skin Skin Tumor Benign Neoplasm Of Skin Skin Neoplasms
Cicatricial Lagophthalmos
Papilloma	Papillomatosis
Acrokeratosis Verruciformis	Acrokeratosis Verruciformis Of Hopf Hopf Disease AKV Akv Of Hopf
Pachyonychia Congenita 1	Pachyonychia Congenita Jadassohn-Lewandowsky Syndrome Pachyonychia Congenita Syndrome PC1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type Congenital Pachyonychia Pachyonychia Congenita, Type 1 Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly Jadassohn-Lewandowsky Syndrome, Formerly Jackson-Lawler Type Pachyonychia Congenita Pachyonychia Congenita Type 1 Jackson-Lawler Syndrome Jadassohn-Lewandowski Syndrome Pc Pachyonychia Congenita Jackson-Lawler Type Pachyonychia Congenita Jadassohn-Lewandowsky Type Pachyonychia Congenita Jackson Lawler Type Pc-1 Pachyonychia Congenita, Jadassohn Lewandowsky Type Pachyonychia Congenita, Type 2
Nevus, Epidermal	Epidermal Nevus Woolly Hair Nevus Epidermal Naevus Epidermal Nevus Syndrome Nevus, Keratinocytic, Nonepidermolytic Epidermal Nevus, Somatic Nevus, Epidermal, Somatic Nevus Sebaceous Or Woolly Hair Nevus, Somatic Nonepidermolytic Keratinocytic Nevus Epidermal Hamartoma Syndrome Wooly Hair Nevus Keratinocytic Non-Epidermolytic Nevus KNEN Pigmented Moles Organoid Nevus Phakomatosis Nevus Sebaceous Melanocytic Nevus Melanocytic Nevus Of Skin
Trichothiodystrophy 1, Photosensitive	TTD1 Tay Syndrome Trichothiodystrophy With Congenital Ichthyosis Photosensitive Trichothiodystrophy Ibids Syndrome Ttdp Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation Ichthyosis, Congenital, With Trichothiodystrophy Pibids Syndrome Photosensitive Trichothiodystrophy 1 Trichothiodystrophy, Photosensitive Sulfur-Deficient Brittle Hair Syndrome Ttd-P Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature Trichothiodystrophy Photosensitive Trichothiodystrophy, Type 1 Tricho-Thiodystrophy Disorder Trichothiodystrophy Syndromes Amish Brittle Hair Brain Syndrome
Acanthoma
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Psoriasis
Toxicodendron Dermatitis	Dermatitis, Toxicodendron Contact Dermatitis Due To Genus Toxicodendron Rhus Dermatitis Dermatitis Toxicodendron
Acrokeratoderma, Hereditary Papulotranslucent	Hereditary Papulotranslucent Acrokeratoderma
Recessive Dystrophic Epidermolysis Bullosa	Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type Rdeb, Hallopeau-Siemens Type Severe Generalized Rdeb Severe Generalized Recessive Dystrophic Epidermolysis Bullosa Rdeb Generalisata Gravis Rdeb, Severe Generalized Rdeb-Sev Gen Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized Hallopeau-Siemens Disease
Erythrasma	Infection Due To Corynebacterium Minutissimum
Ichthyosis, Congenital, Autosomal Recessive 4b	Harlequin Ichthyosis Autosomal Recessive Congenital Ichthyosis 4b Hi Harlequin Fetus ARCI4B Ichthyosis Congenita, Harlequin Fetus Type Harlequin Type Ichthyosis 'Harlequin Fetus' Harlequin Type Ichthyosis Congenita Harlequin Type Ichthyosis Fetalis Harlequin Baby Syndrome Ichthyosis Congenita, Harlequin Type Ichthyosis Fetalis, Harlequin Type Ichthyosis Congenita Harlequin Fetus Type Ichthyosis, Harlequin Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1	Focal Nonepidermolytic Palmoplantar Keratoderma Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma FNEPPK1 Ppkfne Keratoderma, Focal Nonepidermolytic Palmoplantar Palmoplantar Keratoderma, Nonepidermolytic, Focal Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas Fneppk Focal Nonepidermolytic Palmoplantar Keratoderma 1 Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1 Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Erythrokeratodermia Variabilis Et Progressiva 1	Erythrokeratodermia Variabilis Erythrokeratodermia Variabilis Et Progressiva Greither Disease Ekv Ekvp PSEK Erythrokeratodermia Variabilis With Erythema Gyratum Repens Keratosis Palmoplantaris Transgrediens Et Progrediens Transgrediens Et Progrediens Palmoplantar Keratoderma EKVP1 Erythrokeratodermia, Progressive Symmetric Erythrokeratodermia Figurata, Congenital Familial, In Plaques Keratoderma Palmoplantaris Transgrediens Keratosis Extremitatum Hereditaria Progrediens Erythrokeratodermia Variabilis, Mendes Da Costa Type Progressive Symmetric Erythrokeratodermia Erythrokeratodermia Figurata Variabilis Greither'S Disease Ekv-P Erythrokeratodermia Variabilis Of Mendes Da Costa Progressive Symmetrical Erythrokeratoderma Of Gottron Progressive Diffuse Ppk Progressive Diffuse Palmoplantar Keratoderma Transgrediens Et Progrediens Ppk Darier-Gottron Disease Erythrokeratodermia Progressiva Symmetrica Progressive Symmetric Erythrokeratodermia, Gottron Type Congenital Familial Erythrokeratodermia Figurata In Plaques Erythrokeratodermia Progressive Symmetric Erythrokeratodermia Variabilis Mendes Da Costa Type
White Sponge Nevus 1	White Sponge Nevus Of Cannon Leukokeratosis, Hereditary Mucosal Hereditary Mucosal Leukokeratosis White Sponge Nevus WSN1 Wsn Cannon'S Disease Familial White Folded Mucosal Dysplasia Hereditary Leukokeratosis Hereditary Oral Keratosis Leukokeratosis Of Oral Mucosa Nevus Of Cannon White Folded Gingivostomatosis White Gingivostomatitis White Sponge Naevus White Sponge Nevus Of Mucosa
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Skin Papilloma	Cutaneous Papilloma Papilloma Of Skin Papilloma Skin
Porokeratosis	Disseminated Superficial Actinic Porokeratosis Dsap Porokeratosis Of Mibelli Porokeratosis, Disseminated Superficial Actinic Porokeratosis, Disseminated Superficial Actinic, 1
Epidermolysis Bullosa Dystrophica	Dystrophic Epidermolysis Bullosa Deb Dermolytic Epidermolysis Bullosa Epidermolysis Bullosa, Dermolytic Epidermolysis Bullosa, Dystrophic Epidermolysis Bullosa Dystrophic Dystrophic Eb - [Epidermolysis Bullosa]
Epidermolysis Bullosa Simplex 2f, With Mottled Pigmentation	Epidermolysis Bullosa Simplex With Mottled Pigmentation Ebsmp Speckled Hyperpigmentation With Punctate Palmoplantar Keratoses And Childhood Blistering Ebs-Mp EBS2F Ebs With Mottled Pigmentation Epidermolysis Bullosa Simplex-Mp Speckled Hyperpigmentation, Palmo-Plantar Punctate Keratoses And Childhood Blistering Epidermolysis Bullosa Simplex, With Mottled Pigmentation
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10789	P160 peptide	Inhibitor	/	Unkown
HY-P10790	Breast cancer targeting peptide 18–4	Inhibitor	/	Unkown
HY-RS07433	KRT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19346	Krt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25837	Krt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KRT1	VGNC	VGNC:74206
Canis familiaris	KRT1	VGNC	VGNC:42515
Rattus norvegicus	KRT1	RGD	RGD:1359664
Bos taurus	KRT1	VGNC	VGNC:30716
Mus musculus	KRT1	MGD	MGI:96698
Others	KRT1	NCBI