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Cat. No.: HY-150507

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JNJ-4355

(Synonyms: JNJ-78394355)

JNJ-4355, a chemical probe, is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with K_I of 18 pM. JNJ-4355 shows antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 2697112-33-5
Formula: C₄₀H₄₃ClFN₅O₅S
Molecular Weight:760.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

JNJ-4355 Chemical Structure

CAS No.: 2697112-33-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JNJ-4355, a chemical probe, is a highly potent MCL-1 (myeloid cell leukemia-1) inhibitor, with K_I of 18 pM. JNJ-4355 shows antitumor activity^[1]^[2].

IC₅₀ & Target

Mcl-1

18 pM (Ki)

All Bcl-2 Family Isoforms :

In Vitro

JNJ-4355 shows promising in vitro potency data in cancer cell lines and AML patient-derived samples^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JNJ-4355 (IV , single) shows complete tumor regression in a mouse MOLP8 (multiple myeloma) xenograft^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2697112-33-5
Molecular Weight 760.32
Formula C₄₀H₄₃ClFN₅O₅S
SMILES

CC1=C(C(O)=O)N(CCCOC2=CC3=CC4=C2C=CC(F)=C4)C5=CC=C(Cl)C(C6=C(CSCC7=NN(C)C(CC3)=C7)N(CCOCCOC)N=C6C)=C51
Synonyms

JNJ-78394355
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matthieu Jouffroy, et al. Synthesis of Atropisomeric Biaryls via Chiral Suzuki–Miyaura/Enzymatic Kinetic Resolution. ACS Catal. 2022, 12, 8380–8385.

[2]. Frederik J. Rombouts, et al. Abstract 2133: In pursuit of MCL-1 inhibitors with improved therapeutic window for the treatment of hematological malignancies: Discovery of JNJ-4355. Cancer Res (2022) 82 (12_Supplement): 2133.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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JNJ-4355

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JNJ-4355 Related Classifications

HY-150507 Related Classifications