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Cat. No.: HY-113273

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Ap5A

(Synonyms: Diadenosine pentaphosphate)

Ap5A (Diadenosine pentaphosphate), a diadenosine polyphosphate, is an adenylate kinase inhibitor with a K_i of 2.5 nM. Ap5A can be used for study of cancer.

For research use only. We do not sell to patients.

CAS No.: 41708-91-2
Formula: C₂₀H₂₉N₁₀O₂₂P₅
Molecular Weight:916.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Ap5A Chemical Structure

CAS No.: 41708-91-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ap5A (Diadenosine pentaphosphate), a diadenosine polyphosphate, is an adenylate kinase inhibitor with a K_i of 2.5 nM. Ap5A can be used for study of cancer^[1].

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>=5 μM Compound: Ap5A	Activity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increase Activity against rat P2Y1-GFP transfected in HEK293 cells by intracellular calcium increase	[PMID: 16539385]
PC-12	IC₅₀	29 μM Compound: 4	Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced ROS production after 1 hr by DCFH-DA staining-based fluorometric analysis Antioxidant activity in rat PC12 cells assessed as inhibition of Fe2+-induced ROS production after 1 hr by DCFH-DA staining-based fluorometric analysis	[PMID: 23751098]

Chemical Information

CAS No. 41708-91-2
Molecular Weight 916.37
Formula C₂₀H₂₉N₁₀O₂₂P₅
SMILES

O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(OP(OP(OC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2N3C=NC4=C(N)N=CN=C43)(O)=O)(O)=O)(O)=O)(O)=O)(O)=O)O[C@H]1N5C6=NC=NC(N)=C6N=C5
Synonyms

Diadenosine pentaphosphate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bone R, et al. Inhibition of thymidine kinase by P1-(adenosine-5')-P5-(thymidine-5')-pentaphosphate. J Biol Chem. 1986 May 5;261(13):5731-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Ap5A

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Ap5A Related Classifications

HY-113273 Related Classifications