Etazolate
Etazolate (SQ 64442) is a α-secretase activator, selective PDE4 inhibitor, selective GABAA receptor modulator. Etazolate reduces IL-1β levels Etazolate exerts a dose-dependent anti-inflammatory and anti-œdematous effect accompanied by lasting memory improvement. Etazolate produces an antidepressant-like effect.
For research use only. We do not sell to patients.
- CAS No.: 51022-77-6
- Formula: C14H19N5O2
- Molecular Weight:289.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE4 |
IL-1β |
Chemical Information
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CAS No. 51022-77-6
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Molecular Weight 289.33
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Formula C14H19N5O2
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SMILES
C/C(C)=N\NC1=C2C(N(CC)N=C2)=NC=C1C(OCC)=O
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Synonyms
SQ 64442
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Siopi E, et al. Etazolate, an α-secretase activator, reduces neuroinflammation and offers persistent neuroprotection following traumatic brain injury in mice. Neuropharmacology. 2013 Apr;67:183-92. [Content Brief]
[2]. Jindal A, et al. Etazolate, a phosphodiesterase-4 enzyme inhibitor produces antidepressant-like effects by blocking the behavioral, biochemical, neurobiological deficits and histological abnormalities in hippocampus region caused by olfactory bulbectomy. Psychopharmacology (Berl). 2015 Feb;232(3):623-37. [Content Brief]
[3]. Marcade M, et al. Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing. J Neurochem. 2008 Jul;106(1):392-404. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Etazolate Related Classifications
HY-106044 Related Classifications
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