Lysozyme
Based on 8 publication(s) in Google Scholar
Lysozyme (Muramidase) is a conserved antimicrobial protein. Lysozyme exerts its bactericidal effect by hydrolyzing bacterial cell wall peptidoglycan (PG). Lysozyme plays an important role in limiting bacterial growth on mucosal surfaces and other sites, not only controlling potential pathogens but also limiting overgrowth of microbiota to prevent dysbiosis. Extracellular lysozyme can also degrade polymeric PG into soluble fragments, activate NOD receptors in mucosal epithelial cells, and lead to the secretion of chemokines and activating factors by neutrophils and macrophages.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 9001-63-2
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lysozyme
More- Nature. 2023 Jan;613(7942):145-152. [Abstract]
- Immunity. 2025 Apr 8:S1074-7613(25)00128-1. [Abstract]
- Anal Chem. 2025 Mar 18;97(10):5488-5497. [Abstract]
- Microchem J. 2024 Dec.
- J Mol Struct. 5 November 2021, 131868.
- Spectrochim Acta A Mol Biomol Spectrosc. 2024 Jun 8:320:124630. [Abstract]
- PLoS One. 2021 Dec 9;16(12):e0260603. [Abstract]
- J Vet Med Sci. 2021 Sep;7(5):1938-1947. [Abstract]
Biological Activity
Instructions
Use 10 mM Tris-HCl (pH 8.0) to prepare a 1 mg/mL solution. It can also be dissolved in pure water and stored at 2-8°C for 1 week. Avoid repeated freezing and thawing.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Hen Egg Lysozyme (150 mg/kg; i.g.; once daily for 5 days) reduces the extent of inflammation and modulated local gene expression in a piglet model of dextran sodium sulfate (DSS)-induced colitis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DSS-induced colitis piglet model
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Dosage:150 mg/kg (Hen Egg Lysozyme)
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Administration:Once a day for 5 days; gavage
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Result:Reduced the expression of local pro-inflammatory cytokines TNF-R, IL-6, IFN-γ, IL-8, and IL-17, while increasing the expression of anti-inflammatory mediators IL-4 and TGF-β.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
3.2.1.17
>100000 IU/mg protein
Chemical Information
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CAS No. 9001-63-2
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Appearance Solid
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Color White to off-white
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SMILES
[Lysozyme]
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Synonyms
Muramidase
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (8)
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Journal Impact Factor
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Most Recent
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Nature
2023 Jan;613(7942):145-152. PMID: 36517600 -
Immunity
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation. [Abstract]2025 Apr 8:S1074-7613(25)00128-1. PMID: 40215968 -
Anal Chem
2025 Mar 18;97(10):5488-5497. PMID: 40035313 -
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Spectrochim Acta A Mol Biomol Spectrosc
Design of "Off-On-Off" fluorescence sensors for Heparin detection by precise modulation of molecular structure. [Abstract]2024 Jun 8:320:124630. PMID: 38865888 -
PLoS One
Optimization of layering technique and secondary structure analysis during the formulation of nanoparticles containing lysozyme by quality by design approach. [Abstract]2021 Dec 9;16(12):e0260603. PMID: 34882727 -
J Vet Med Sci
Elevated temperatures accelerate the formation of toxic amyloid fibrils of hen egg-white lysozyme. [Abstract]2021 Sep;7(5):1938-1947. PMID: 33978313
Solvent & Solubility
H2O : 4.76 mg/mL (ultrasonic and adjust pH to 4 with 0.1 M HCl)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Feingold DS, et al. Locus of the action of serum and the role of lysozyme in the serum bactericidal reaction. J Bacteriol. 1968 Dec;96(6):2118-26. [Content Brief]
[2]. Ragland S A, et al. From bacterial killing to immune modulation: Recent insights into the functions of lysozyme[J]. PLoS pathogens, 2017, 13(9): e1006512. [Content Brief]
[3]. Markart P, et al. Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection[J]. American journal of respiratory and critical care medicine, 2004, 169(4): 454-458. [Content Brief]
[4]. Lee M, et al. Hen egg lysozyme attenuates inflammation and modulates local gene expression in a porcine model of dextran sodium sulfate (DSS)-induced colitis[J]. Journal of agricultural and food chemistry, 2009, 57(6): 2233-2240. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lysozyme Related Classifications
HY-P1068 Related Classifications
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