2-5A
2-5A is a RNase L activator, signal mediator and innate immune second messenger. 2-5A induces the expression of interferons and interferon-stimulated genes in recipient cells in a RNase L-dependent manner. 2-5A inhibits tumor growth in mouse models via paracrine RNase L activation derived from cancer cells. 2-5A can be used in studies related to viral infection and cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 65954-93-0
- 分子式: C30H40N15O25P5
- 分子量:1165.59
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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RNASE L |
2-5A induces paracrine RNase L activation in co-cultured A549 human lung adenocarcinoma epithelial cell lines, with activation triggered by poly(I:C) treatment or expression of the constitutively active OAS1A76V mutant[1].
2-5A is exported extracellularly by poly(I:C)-stimulated MC38 murine colon adenocarcinoma cells via the ABCC10 and ABCC1 transporters[1].
Trimeric 2-5A is taken up by HEK293T human embryonic kidney cells and BJ1 human foreskin fibroblasts to induce RNase L-dependent IFN/ISG activation, with LRRC8A and P2X7R contributing to 2-5A import in HEK293T cells[1].
2-5A export via gap junctions (A549 cells) or ABCC10 (MC38 cells) mediates paracrine OAS-RNase L activation and antiviral immunity against VSV and SeV infection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 65954-93-0
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分子量 1165.59
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分子式 C30H40N15O25P5
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OP(O)(OC[C@@H](O[C@H]([C@@H]4OP(O)(OC[C@@H](O[C@H]([C@@H]5O)N6C=NC7=C6N=CN=C7N)[C@H]5O)=O)N8C=NC9=C8N=CN=C9N)[C@H]4O)=O)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3
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別名
2′,5′-ApApA; 2′,5′-trioligoadenylate; 5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
2-5A 関連分類
HY-173189 関連分類
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