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Baricitinib

(別名: LY3009104; INCB028050)
78 Cited Publications
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Based on 78 publication(s) in Google Scholar

Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.

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  • 純度: 99.93%
  • CAS 番号: 1187594-09-7
  • 分子式: C16H17N7O2S
  • 分子量:371.42
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Baricitinib Chemical Structure
  • Experimental Validation Results for Baricitinib
  • Experimental Validation Results for Baricitinib
  • Experimental Validation Results for Baricitinib
  • Baricitinib Chemical Structure
    Baricitinib 構造式
  • Experimental Validation Results for Baricitinib
  • Experimental Validation Results for Baricitinib
  • Experimental Validation Results for Baricitinib
CAS 番号: 1187594-09-7
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  • Baricitinib Chemical Structure
    Baricitinib Chemical Structure
    1/16
  • 1/16

    Baricitinib purchased from MedChemExpress. Usage Cited in: RSC Adv. 2018 Jun 13;8(38):21534-21540. [Abstract]

    Customer Validation
     M14 and A2058 cells are treated with IFN-γ (10 ng/mL) after Lac (100 μg/mL) or baricitinib (0.5 μM) for the indicated times. Whole cell lysates are subjected to western blotting.

  • 1/16

    Baricitinib purchased from MedChemExpress. Usage Cited in: University of Toyama. 2018, Nov.

    Customer Validation
     Western analysis of pJAK2, JAK2, pSTAT1, STAT1 and IRF1 protein in M14 and A2058 cells treated with IFN-g (10 ng/mL) after Lac (100 μg/mL) or baricitinib (0.5 μM) for the indicated times.

  • 1/16

    Baricitinib purchased from MedChemExpress. Usage Cited in: PLoS One. 2017 Jul 14;12(7):e0181126. [Abstract]

    Customer Validation
     An activator of Stat3, colivelin (0.1 or 1 µM), rescued Baricitinib-induced RANKL down-regulation in osteoblast cultures.

  • Baricitinib