C-7280948
Based on 1 Customer Validation
C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC50 value of 12.75 μM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.91%
- CAS 番号: 587850-67-7
- 分子式: C14H16N2O2S
- 分子量:276.35
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Peptidomimetic Library
HY-L033
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Reprogramming Compound Library
HY-L039
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Anti-Blood Cancer Compound Library
HY-L079
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Targeted Diversity Library
HY-L099
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Highly Selective Inhibitors Library
HY-L158
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Methylation Compound Library
HY-L203
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Histone Methyltransferase アイソフォーム固有の製品をすべて表示
More
生物活性
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PRMT1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>50 μg/mL
Compound: 2a
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Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
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10.1007/s00044-013-0777-z |
| HepG2 | IC50 |
>50 μg/mL
Compound: 2a
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Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
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10.1007/s00044-013-0777-z |
| HuCC-A1 | IC50 |
>50 μg/mL
Compound: 2a
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Cytotoxicity against human HuCCa1 cells after 48 hrs by MTT assay
Cytotoxicity against human HuCCa1 cells after 48 hrs by MTT assay
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10.1007/s00044-013-0777-z |
| MOLT-3 | IC50 |
166.6 μM
Compound: 2a
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Cytotoxicity against human MOLT3 cells after 48 hrs by XTT assay
Cytotoxicity against human MOLT3 cells after 48 hrs by XTT assay
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10.1007/s00044-013-0777-z |
C-7280948 is compound 6a in this article, it against hPRMT1 with an IC50 value of 12.75 μM.Especially arginine methyltransferases also target non-histone protein substrates and are therefore often called protein methyltransferases (PRMTs).The subtype PRMT1 has been linked to the activation of estrogen and androgen receptors and therefore may represent a new treatment option for hormone-dependent cancer.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 587850-67-7
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性状 Solid
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分子量 276.35
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分子式 C14H16N2O2S
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Color White to off-white
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SMILES
O=S(C1=CC=C(N)C=C1)(NCCC2=CC=CC=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : ≥ 38 mg/mL (137.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6186 mL | 18.0930 mL | 36.1860 mL | 90.4650 mL |
| 5 mM | 0.7237 mL | 3.6186 mL | 7.2372 mL | 18.0930 mL | |
| 10 mM | 0.3619 mL | 1.8093 mL | 3.6186 mL | 9.0465 mL | |
| 15 mM | 0.2412 mL | 1.2062 mL | 2.4124 mL | 6.0310 mL | |
| 20 mM | 0.1809 mL | 0.9046 mL | 1.8093 mL | 4.5232 mL | |
| 25 mM | 0.1447 mL | 0.7237 mL | 1.4474 mL | 3.6186 mL | |
| 30 mM | 0.1206 mL | 0.6031 mL | 1.2062 mL | 3.0155 mL | |
| 40 mM | 0.0905 mL | 0.4523 mL | 0.9046 mL | 2.2616 mL | |
| 50 mM | 0.0724 mL | 0.3619 mL | 0.7237 mL | 1.8093 mL | |
| 60 mM | 0.0603 mL | 0.3015 mL | 0.6031 mL | 1.5077 mL | |
| 80 mM | 0.0452 mL | 0.2262 mL | 0.4523 mL | 1.1308 mL | |
| 100 mM | 0.0362 mL | 0.1809 mL | 0.3619 mL | 0.9046 mL |
C-7280948 関連分類
HY-15890 関連分類
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