Cefpiramide sodium
Based on 1 Customer Validation
Cefpiramide sodium (SM-1652) is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide sodium shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide sodium is moderately susceptible to β-lactamase.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.82%
- CAS 番号: 74849-93-7
- 分子式: C25H23N8NaO7S2
- 分子量:634.62
-
保管条件:
-20°C, sealed storage, away from moisture and light
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
HY-B1892
CefazolinCephalosporin Antibiotic -
HY-B1892R
Cefazolin (Standard)Cephalosporin Antibiotic -
HY-B1300
Cefonicid sodiumAntibiotic -
HY-B0441A
Tobramycin sulfateAminoglycoside Antibiotic -
HY-128449
Cephradine monohydrateCephalosporin Antibiotic -
HY-B1300R
Cefonicid sodium (Standard)Standard -
HY-B0441AR
Tobramycin sulfate (Standard)Bacterial Inhibitor
生物活性
製品説明
|
β-lactam |
体外実験
Cefpiramide (0-2048 μg/mL; 16-18 hours) sodium (SM-1652) shows good activity to against most non-fermentative Gram-negative bacilli and Enterococci (32 μg/mL with 97% inhibition)[1].
Cefpiramide (0-2048 μg/mL; 16-18 hours) sodium exhibits high effective to against Pseudomonas aeruginosa with MIC[50] and MIC[90] values of 4 μg/mL and 16 μg/mL separately[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:761 bacterial isolates (35 different species of common bacterial pathogens)
-
Concentration:0-2048 µg/mL
-
Incubation Time:16-18 hours
-
Result:Showed broad-spectrum antibacterial activity.
体内実験
Cefpiramide (25 mg/kg; i.v.; once) sodium reduces bacteria in CSF more than 10[4] CFU/ml[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:New Zealand white male rabbits(2-3 kg)[2].
-
Dosage:25 mg/kg
-
Administration:Intravenous injection; once.
-
Result:Anti-Streptococcus pneumoniae.
化学情報
-
CAS 番号 74849-93-7
-
性状 Solid
-
分子量 634.62
-
分子式 C25H23N8NaO7S2
-
Color White to off-white
-
SMILES
O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC([C@H](NC(C4=C(O)C=C(C)N=C4)=O)C5=CC=C(O)C=C5)=O)C1=O)O[Na]
-
別名
SM-1652; Wy-44635
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
-20°C, sealed storage, away from moisture and light
* The compound is unstable in solutions, freshly prepared is recommended.
溶剤 & 溶解度
体外:
DMSO : 58.33 mg/mL (91.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.28 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.28 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
-
データシート (287 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Barry AL, et al. Cefpiramide: comparative in-vitro activity and beta-lactamase stability. J Antimicrob Chemother. 1985 Sep;16(3):315-25. [Content Brief]
[2]. Sato K, et al. Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. Antimicrob Agents Chemother. 1984 Oct;26(4):578-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5757 mL | 7.8787 mL | 15.7575 mL | 39.3937 mL |
| 5 mM | 0.3151 mL | 1.5757 mL | 3.1515 mL | 7.8787 mL | |
| 10 mM | 0.1576 mL | 0.7879 mL | 1.5757 mL | 3.9394 mL | |
| 15 mM | 0.1050 mL | 0.5252 mL | 1.0505 mL | 2.6262 mL | |
| 20 mM | 0.0788 mL | 0.3939 mL | 0.7879 mL | 1.9697 mL | |
| 25 mM | 0.0630 mL | 0.3151 mL | 0.6303 mL | 1.5757 mL | |
| 30 mM | 0.0525 mL | 0.2626 mL | 0.5252 mL | 1.3131 mL | |
| 40 mM | 0.0394 mL | 0.1970 mL | 0.3939 mL | 0.9848 mL | |
| 50 mM | 0.0315 mL | 0.1576 mL | 0.3151 mL | 0.7879 mL | |
| 60 mM | 0.0263 mL | 0.1313 mL | 0.2626 mL | 0.6566 mL | |
| 80 mM | 0.0197 mL | 0.0985 mL | 0.1970 mL | 0.4924 mL |
Cefpiramide sodium 関連分類
HY-B0798 関連分類
Powered by Bioz