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DAPT

(別名: GSI-IX)
169 Cited Publications
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Based on 169 publication(s) in Google Scholar

DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.

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  • 純度: 99.97%
  • CAS 番号: 208255-80-5
  • 分子式: C23H26F2N2O4
  • 分子量:432.46
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • DAPT Chemical Structure
    DAPT 構造式
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
  • Experimental Validation Results for DAPT
CAS 番号: 208255-80-5
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  • DAPT Chemical Structure
    DAPT Chemical Structure
    1/16
  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Oct 20;14(1):6669. [Abstract]

    Customer Validation
     Dose response curve assessed as percentage of cell viability of two ATRT cell lines, upon treatment with DAPT.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Oct 20;14(1):6669. [Abstract]

    Customer Validation
     Western blot analyses for Notch intracellular domain NICD in CHLA-02 and IC-032 cell lines treated with DAPT (10 µM; 7 days) NOTCH inhibitor or DMSO as a control.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Nov:246:114183. [Abstract]

    Customer Validation
     DAPT treatment enhances the protein expression of Bax and decreases the expression of Bcl2. And the expression of cleaved-caspase3 is upregulated after DAPT treatment (10 μM; for 24 h).

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2022 Nov:246:114183. [Abstract]

    Customer Validation
     Detection of cell viability after treatment with different concentrations of DAPT (5 μM, 10 μM, 15 μM, 20 μM; for 24 h).

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Neural Regen Res. 2019 Mar;14(3):452-461. [Abstract]

    Customer Validation
     Western blot assay for Hes1 (left) and Hes5 (right) protein expression in the right prefrontal cortex of cerebral I/R mice following DAPT treatment.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Nov:107:1370-1376. [Abstract]

    Customer Validation
     ECa109 and EC9706 cells are treated with concentrations of GSI-DAPT (0, 10 and 20 μM) for 48 h. The expressions of Notch3, DTX1 and Hes1 are investigated by Western blotting.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Nov:107:1370-1376. [Abstract]

    Customer Validation
     ECa109 and EC9706 cells are treated with concentrations of GSI-DAPT (0, 10 and 20 μM) for 48 h. The expressions of LSD1 and H3K4me2 are investigated by Western blotting.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2018 Nov 8:12:3847-3854. [Abstract]

    Customer Validation
     Western anslysis of protein analysis of NOX2, NICD, Hes1, Hes5 in the treatment of TBI, TBI+vehicle, TBI+DAPT and TBI+DPI, respectively.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Int J Cancer. 2018 Aug 1;143(3):645-656. [Abstract]

    Customer Validation
     Evaluation of expression change of Notch downstream under the androgen-deprived condition with or without the treatment of DAPT by western blot assay.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2018 Mar;233(3):2225-2237. [Abstract]

    Customer Validation
     DAPTprevents Nicd splitting from Notch1 and has been recognized as a Notch1 pathway inhibitor. Treatment with DAPT also inhibits the expression of Col IV and FN, resembling the effect of Notch1 siRNA.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Feb;120(2):1903-1915. [Abstract]

    Customer Validation
     The distribution of aggrecan is increased in the DAPT group.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Feb 15;13(2):e0193037. [Abstract]

    Customer Validation
     After DAPT treatment, the protein levels of Notch, Hes1 and Hes5 are downregulated in severe injury group. After DAPT treatment, the protein levels of Bcl-2 are upregulated while those of Bax, caspase-3 and caspase-9 are downregulated.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: World J Gastroenterol. 2017 Apr 7;23(13):2330-2336. [Abstract]

    Customer Validation
     Notch γ-secretase inhibitor attenuates notch and transforming growth factor-β signaling pathways in peripheral blood mononuclear cells of liver fibrosis rats. Western blot analysis of protein expression of Notch1, Hes1, Hes5, TGF-β and Smad3 and quantification in PBMCs (2 × 106) from rats treated with DAPT or DMSO for 24 h.

  • 1/16

    DAPT purchased from MedChemExpress. Usage Cited in: Yale University. 2016 Jan.

    Customer Validation
     Treatment with DAPT does not markedly alter expression of p27Kip1 in bulk or CD133- cells, but dramatically enhances its expression in CD133+ cells.

  • DAPT