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Lurbinectedin

(別名: PM01183; LY-01017)
12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.

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  • 純度 : 99.70%
  • CAS 番号: 497871-47-3
  • 分子式: C41H44N4O10S
  • 分子量:784.87
  • 保管条件:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Lurbinectedin Chemical Structure
    Lurbinectedin 構造式
  • Experimental Validation Results for Lurbinectedin
  • Experimental Validation Results for Lurbinectedin
  • Experimental Validation Results for Lurbinectedin
  • Experimental Validation Results for Lurbinectedin
  • Experimental Validation Results for Lurbinectedin
  • Experimental Validation Results for Lurbinectedin
CAS 番号: 497871-47-3
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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MedChemExpress（MCE）の使用を引用している文献 Lurbinectedin

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Cell Proliferation/Viability AssayApoptosis AnalysisCell Imaging/StainingWBBio/Physico-chemical Assay2D/3D Cell Culture and Differentiation
  • Cell Proliferation/Viability Assay
  • Apoptosis Analysis
  • Cell Imaging/Staining
  • WB
  • Bio/Physico-chemical Assay
  • 2D/3D Cell Culture and Differentiation

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  • Lurbinectedin Chemical Structure
    Lurbinectedin Chemical Structure
    1/16
  • 1/16

    Lurbinectedin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Sep 18;26(18):9085. [Abstract]

    Customer Validation
     Effect Lurbinectedin on the viability of intrahepatic cholangiocarcinoma cell lines. Cell viability of six human intrahepatic cholangiocarinoma (iCCA) cell lines (CCLP1, HUCCT1, KKU055, KKU156, KKU213, and SG231) exposed to 0-100 nM Lurbinectedin for 48 h was assessed by MTT assay. A summary of the IC50 of the conpound in the six cell lines is depicted next to the graph. Dashed horizontal lines indicate 50% cell viability.

  • 1/16

    Lurbinectedin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Sep 18;26(18):9085. [Abstract]

    Customer Validation
     Apoptosis was assessed in HUCCT1, CCLP1, KU055, KKU156, KKU213 and SG231 cell lines treated for 48 hours with trabectedin (TRB) and Lurbinectedin (LUR) at 1 nM and 5 nM concentrations. Cells treated with solvent (DMSO) served as controls.

  • 1/16

    Lurbinectedin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Sep 18;26(18):9085. [Abstract]

    Customer Validation
     Lurbinectedin (LUR) restrain the growth of HUCCT1 and KKU213 intrahepatic cholangiocarcinoma cells grown as 3D cultures (spheroids). HUCCT1- and KKU213-derived spheroids were treated with DMSO (vehicle) and increasing concentrations of trabectedin (TRB) and lurbinectedin (LUR; 0.25–2 nM; n = 3 wells per condition). Note the decrease in size and number of spheroids following the treatment with Lurbinectedin (LUR), as assessed by the optical microscope. Original magnification: 10×; scale bar: 100 µm.

  • 1/16

    Lurbinectedin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Sep 18;26(18):9085. [Abstract]

    Customer Validation
     Western blot analysis was applied to assess the levels of several effectors of DNA damage response and apoptosis pathways in HUCCT1, SG231, CCLP1, and KKU055 intrahepatic cholangiocarcinoma (iCCA) cell lines exposed to trabectedin (TRB) and Lurbinectedin (LUR) at 1 nM concentration. Cells were treated for 48 h, and Western blot analysis was conducted at this time point. Representative blots are shown.

  • 1/16

    Lurbinectedin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Sep 18;26(18):9085. [Abstract]

    Customer Validation
     Effect of trabectedin and Lurbinectedin (LUR) on the mitochondrial respiration of human intrahepatic cholangiocarcinoma cells. For the Seahorse XF Mito Stress Test, KKU055 cells were treated with 1 nM Lurbinectedin (LUR), or a matched DMSO concentration for 24 h. The Seahorse Mito Stress Test profile of normalized oxygen consumption rate (OCR) in LUR-treated KKU055 cells is shown. The results showed LUR administration significantly decreased most parameters (basal and compensatory glycolysis, and basal proton efflux rate). All OCR levels were background corrected and normalized to nuclei fluorescent staining. Dotted lines indicate the time point of compound injection. Cell #, cell number; FCCP, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone; Rot/AA, rotenone/antimycin A.

  • 1/16

    Lurbinectedin purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Sep 18;26(18):9085. [Abstract]

    Customer Validation
     Microscopic images demonstrate that treatment with trabectedin (TRB) and Lurbinectedin (LUR) (2.5-20 nM; 72 h) resulted in a reduction in the compact, well-organized structure of the organoids, evidenced by the loss of the typical cystic shape associated with cholangiocarcinoma organoids.

  • Lurbinectedin