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Based on 1 publication(s) in Google Scholar
Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.65%
- CAS 番号: 3366-95-8
- 分子式: C7H11N3O3
- 分子量:185.18
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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MedChemExpress（MCE）の使用を引用している文献 Secnidazole
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生物活性
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Amebae |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| THP-1 | IC50 |
>1350 μM
Compound: 6
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Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide-based flow cytometry
Cytotoxicity against human THP1 cells after 72 hrs by propidium iodide-based flow cytometry
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[PMID: 18590939] |
Secnidazole (RP-14539) (0-5000 μM; 5 or 10 min) inhibits CYP2C19 and CYP3A4, with IC50 values of 3873 μM and 3722 μM, respectively[2].
Secnidazole (0-5000 μM; 5 or 10 min) does not exhibit time-dependent inhibition[2].
Secnidazole (0-5000 μM; 5 or 10 min) has an apparent IC50 value of 503 μM for direct inhibition of human ALDH2[2].
Secnidazole (0-5000 μM; 5 or 10 min) has concentration-dependent inhibition at higher concentration with some of the CYP isoforms notably CYP2A6, CYP2B6, and CYP2D6[2].
Secnidazole (10 μL; 20 h; the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL) inhibits S.marcescens growth with a MIC50 value of 10 mg/mL[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:S.marcescens
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Concentration:10 μL (the secnidazole solution was two-fold serially diluted using Mueller–Hinton broth to obtain dilutions ranging from 80 to 0.3125 mg/mL)
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Incubation Time:20 h
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Result:Had no inhibitory effect on S.marcescens growth at 2 mg/mL (equivalent to 1/5 MIC).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female healthy albino mice[3]
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Dosage:100 μL
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Administration:100 μL; ip.; for 5 days
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Result:Significantly diminished the bacteria s capacity to kill mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 3366-95-8
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性状 Solid
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分子量 185.18
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分子式 C7H11N3O3
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Color White to off-white
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SMILES
OC(C)CN1C([N+]([O-])=O)=CN=C1C
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別名
Secnidazole; RP-14539; PM-185184
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Drug Deliv Transl Res
Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [Abstract]2025 Oct 29. PMID: 41160380
溶剤 & 溶解度
DMSO : ≥ 30 mg/mL (162.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (135.00 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (270.01 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (280 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Secnidazole. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury, National Institute of Diabetes and Digestive and Kidney Diseases, 25 February 2020. [Content Brief]
[2]. Helen S Pentikis, et al. In vitro metabolic profile and drug-drug interaction assessment of secnidazole, a high-dose 5-nitroimidazole antibiotic for the treatment of bacterial vaginosis. Pharmacol Res Perspect. 2020 Aug;8(4):e00634. [Content Brief]
[3]. Ahdab N Khayyat, et al. Secnidazole Is a Promising Imidazole Mitigator of Serratia marcescens Virulence. Microorganisms. 2021 Nov 11;9(11):2333. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.4002 mL | 27.0008 mL | 54.0015 mL | 135.0038 mL |
| 5 mM | 1.0800 mL | 5.4002 mL | 10.8003 mL | 27.0008 mL | |
| 10 mM | 0.5400 mL | 2.7001 mL | 5.4002 mL | 13.5004 mL | |
| 15 mM | 0.3600 mL | 1.8001 mL | 3.6001 mL | 9.0003 mL | |
| 20 mM | 0.2700 mL | 1.3500 mL | 2.7001 mL | 6.7502 mL | |
| 25 mM | 0.2160 mL | 1.0800 mL | 2.1601 mL | 5.4002 mL | |
| 30 mM | 0.1800 mL | 0.9000 mL | 1.8001 mL | 4.5001 mL | |
| 40 mM | 0.1350 mL | 0.6750 mL | 1.3500 mL | 3.3751 mL | |
| 50 mM | 0.1080 mL | 0.5400 mL | 1.0800 mL | 2.7001 mL | |
| 60 mM | 0.0900 mL | 0.4500 mL | 0.9000 mL | 2.2501 mL | |
| 80 mM | 0.0675 mL | 0.3375 mL | 0.6750 mL | 1.6875 mL | |
| 100 mM | 0.0540 mL | 0.2700 mL | 0.5400 mL | 1.3500 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Secnidazole 関連分類
HY-B1118 関連分類
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