ALLM
Based on 1 publication(s) in Google Scholar
ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.60%
- CAS 番号: 110115-07-6
- 分子式: C19H35N3O4S
- 分子量:401.56
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 ALLM
MoreCathepsin アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>100 μM
Compound: 119
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Cytotoxicity against human A549 cells assessed as reduction in cell viability by neutral red uptake assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by neutral red uptake assay
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[PMID: 34798775] |
| Caco-2 | CC50 |
>100 μM
Compound: 119
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Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability by neutral red uptake assay
Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability by neutral red uptake assay
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[PMID: 34798775] |
| HeLa | IC50 |
23.7 μM
Compound: 2
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Antiviral activity against human rhinovirus-14 in HeLa cells
Antiviral activity against human rhinovirus-14 in HeLa cells
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10.1016/S0960-894X(96)00537-9 |
| MDCK | CC50 |
>100 μM
Compound: 119
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Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by neutral red uptake assay
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by neutral red uptake assay
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[PMID: 34798775] |
| Vero | CC50 |
>100 μM
Compound: 119
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by neutral red uptake assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by neutral red uptake assay
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[PMID: 34798775] |
| Vero C1008 | EC50 |
2.07 μM
Compound: 19
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Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral replication incubated for 48 hrs by CPE assay
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in viral replication incubated for 48 hrs by CPE assay
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[PMID: 37244162] |
ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Wistar rats (280-300g) (spinal cord injury model)[2]
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Dosage:0.05, 0.5, and 2.5 mg/kg
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Administration:Intraperitoneally; every 24 h for 1 week
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Result:Showed significantly better motor function.
化学情報
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CAS 番号 110115-07-6
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性状 Solid
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分子量 401.56
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分子式 C19H35N3O4S
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Color White to off-white
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SMILES
CSCC[C@@H](C=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C)=O)=O)=O
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別名
Calpain inhibitor II
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Cancer
2025 Jul 17;24(1):197. PMID: 40676628
溶剤 & 溶解度
DMF : ≥ 20 mg/mL (49.81 mM)
Ethanol : ≥ 20 mg/mL (49.81 mM)
DMSO : ≥ 20 mg/mL (49.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Stangl V, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J. 2004 Feb;18(2):272-9. [Content Brief]
[2]. Arataki S, et al. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J Neurotrauma. 2005 Mar;22(3):398-406. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF / Ethanol / DMSO | 1 mM | 2.4903 mL | 12.4514 mL | 24.9029 mL | 62.2572 mL |
| 5 mM | 0.4981 mL | 2.4903 mL | 4.9806 mL | 12.4514 mL | |
| 10 mM | 0.2490 mL | 1.2451 mL | 2.4903 mL | 6.2257 mL | |
| 15 mM | 0.1660 mL | 0.8301 mL | 1.6602 mL | 4.1505 mL | |
| 20 mM | 0.1245 mL | 0.6226 mL | 1.2451 mL | 3.1129 mL | |
| 25 mM | 0.0996 mL | 0.4981 mL | 0.9961 mL | 2.4903 mL | |
| 30 mM | 0.0830 mL | 0.4150 mL | 0.8301 mL | 2.0752 mL | |
| 40 mM | 0.0623 mL | 0.3113 mL | 0.6226 mL | 1.5564 mL |
ALLM 関連分類
HY-118355 関連分類
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