製品番号: HY-N8912

Ambrosin

Ambrosin is an orally active NF-κβ and BACE1 inhibitor. Ambrosin reduces pro-inflammatory and nitrosative mediators, increases PPARγ levels, inhibits apoptosis (Apoptosis), enhances autophagy (Autophagy), and ameliorates oxidative stress. Ambrosin reduces Amyloid plaque deposition. Ambrosin improves lipopolysaccharide-induced memory impairment and colonic histopathological changes. Ambrosin can be used in research related to Alzheimer's disease and colitis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 509-93-3
分子式: C₁₅H₁₈O₃
分子量:246.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Ambrosin 構造式

CAS 番号: 509-93-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[2]^[1]

PPAR-γ

BACE1

NF-κB アイソフォーム固有の製品をすべて表示 :

Beta-secretase アイソフォーム固有の製品をすべて表示 :

BACE1
BACE2

PPAR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	GI₅₀	1.8 μM Compound: 1	The compound was evaluated for cytotoxicity against colon cancer cell line HCT116 The compound was evaluated for cytotoxicity against colon cancer cell line HCT116	[PMID: 7650694]
KB	ED₅₀	0.45 μg/mL Compound: 12. Ambrosin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 17336532]
KB	ED₅₀	1.83 μM Compound: ambrosin	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 18329753]
LOX IMVI	GI₅₀	2.2 μM Compound: 1	The compound was evaluated for cytotoxicity against melanoma cell line LOX-IMVI The compound was evaluated for cytotoxicity against melanoma cell line LOX-IMVI	[PMID: 7650694]
LOX IMVI	GI₅₀	2.2 μM Compound: 6	Antiproliferative activity against human LOXIMVI cells Antiproliferative activity against human LOXIMVI cells	10.1039/C2MD20172K
MCF7	GI₅₀	3.9 μM Compound: 1	The compound was evaluated for cytotoxicity against breast cancer cell line MCF-7 The compound was evaluated for cytotoxicity against breast cancer cell line MCF-7	[PMID: 7650694]
MCF7	GI₅₀	3.9 μM Compound: 6	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	10.1039/C2MD20172K
NCI-H522	GI₅₀	1 μM Compound: 1	The compound was evaluated for cytotoxicity against lung cancer cell line NCI-H522 The compound was evaluated for cytotoxicity against lung cancer cell line NCI-H522	[PMID: 7650694]
NCI-H522	GI₅₀	1 μM Compound: 6	Antiproliferative activity against human NCI-H522 cells Antiproliferative activity against human NCI-H522 cells	10.1039/C2MD20172K
OVCAR-5	GI₅₀	4.9 μM Compound: 1	The compound was evaluated for cytotoxicity against ovarian cancer cell line OVCAR-5 The compound was evaluated for cytotoxicity against ovarian cancer cell line OVCAR-5	[PMID: 7650694]
PC-3	GI₅₀	4.5 μM Compound: 1	The compound was evaluated for cytotoxicity against prostate cancer cell line PC-3 The compound was evaluated for cytotoxicity against prostate cancer cell line PC-3	[PMID: 7650694]
SF-539	GI₅₀	2.9 μM Compound: 1	The compound was evaluated for cytotoxicity against CNS cancer cell line CNS SF-539 The compound was evaluated for cytotoxicity against CNS cancer cell line CNS SF-539	[PMID: 7650694]
SN12C	GI₅₀	3.4 μM Compound: 1	The compound was evaluated for cytotoxicity against renal cancer cell line SN12C The compound was evaluated for cytotoxicity against renal cancer cell line SN12C	[PMID: 7650694]

体外実験

OthersInnate Immunity

Others

Ambrosin exhibits predicted high gastrointestinal absorption, favorable lipid solubility, and robust BBB permeability, indicating superior pharmacokinetic properties for central nervous system targeting compared to curcumin^[1].

Innate Immunity

Ambrosin binds to the NF-κβp65-DNA complex via hydrogen bonding and hydrophobic interactions, indicating reversible inhibition of NF-κβp65 activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Innate ImmunityCytokines & ChemokinesAβ/Tau/α-Synuclein AggregationInflammasomeOxidative StressAutophagyApoptosis

Innate Immunity

Cytokines & Chemokines

Aβ/Tau/α-Synuclein Aggregation

Ambrosin (5-10 mg/kg; i.p.; daily; 7 days) ameliorates LPS-induced Alzheimer's disease-like pathology in mice by inhibiting NF-κβp65 and downstream mediators, improving memory function, reducing neuroinflammation, decreasing amyloidogenesis, and protecting neurons, with the 10 mg/kg dose showing greater efficacy^[1].

Innate Immunity

Cytokines & Chemokines

Inflammasome

Oxidative Stress

Autophagy

Apoptosis

Ambrosin (10 mg/kg; p.o.) significantly mitigates DSS-induced colitis in male BALB/c mice by restoring antioxidant balance, suppressing pro-inflammatory signaling pathways, enhancing autophagy, and inhibiting apoptosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Albino mice (mature male, 120-130 g, LPS-induced Alzheimer's disease model)^[1]
Dosage:

5 mg/kg; 10 mg/kg
Administration:

i.p.; daily; 7 days
Result:

Reduced mean escape latency time on days 3 and 4 to levels similar to the normal group (significantly lower than LPS control).
Increased mean time spent in the target quadrant to 25.59 sec (5 mg/kg) and 25.56 sec (10 mg/kg; LPS control: 12.20 sec; normal group: 23.38 sec).
Increased time spent exploring the novel object vs. the familiar object, and yielded significantly positive discrimination indices (significantly different from LPS control with negative index).
Reduced LPS-induced elevated NF-κβp65 transcript and protein levels in a dose-dependent manner, with 10 mg/kg reducing protein levels to values not significantly different from the normal group.
Significantly reduced LPS-induced elevated TNF-α, IL-1β, COX-2, and iNOS protein levels at 5 mg/kg; reduced these markers to levels similar to the normal group at 10 mg/kg.
Reduced LPS-induced elevated BACE1 protein levels in a dose-dependent manner.
Increased surviving hippocampal CA1 neurons to 35.66 per high power field (5 mg/kg; LPS control: 23.33) and 44.33 per high power field (10 mg/kg).
Reduced amyloid plaques to 2.50 per high power field (5 mg/kg; LPS control: 6.20) and 0.90 per high power field (10 mg/kg).

Animal Model:

BALB/c (male, 16-26 g, DSS-induced colitis)^[2]
Dosage:

10 mg/kg
Administration:

p.o.
Result:

Significantly reduced disease activity index (DAI).
Restored colon length compared to DSS-only treated mice.
Increased colonic tissue levels of SIRT1, PPAR-γ, glutathione reductase, glutathione peroxidase, Nrf2, beclin-1, LC3-II, and Bcl-2.
Significantly decreased colonic tissue levels of ROS, iNOS, TLR-4, IL-1β, IL-6, TGF-β1, phospho-p38 MAPK, c-Fos, c-Jun, NLRP3 inflammasome, and caspase-8.
Attenuated DSS-induced histopathological damage, including reduced ulceration, crypt loss, and inflammatory cell infiltration.
Lowered histological disease score.
Reduced NF-κB (p65) nuclear immunostaining.
Improved electron microscopic features of colonic cells (nearly normal apical microvilli, mild cytoplasmic vacuolation, and mild mitochondrial swelling with partially destructed cristae).

Related Protocols :

化学情報

CAS 番号 509-93-3
分子量 246.31
分子式 C₁₅H₁₈O₃
SMILES

C[C@]12[C@]3([C@](C(=C)C(=O)O3)(CC[C@H](C)[C@@]1(C=CC2=O)[H])[H])[H]
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (283 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Khalil MNA, et al. Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin. PloS one. 2019;14(7):e0219378. [Content Brief]

[2]. Kabel AM, et al. Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling. Pharmaceuticals (Basel, Switzerland). 2022 May 13;15(5):600. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ambrosin

NF-κB アイソフォーム固有の製品をすべて表示

Beta-secretase アイソフォーム固有の製品をすべて表示

PPAR アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC₅₀ & Target

Cellular Effect

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

Ambrosin

NF-κB アイソフォーム固有の製品をすべて表示

Beta-secretase アイソフォーム固有の製品をすべて表示

PPAR アイソフォーム固有の製品をすべて表示

生物活性

製品説明

IC50 & Target

Cellular Effect

体外実験

体内実験

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Ambrosin 関連分類

HY-N8912 関連分類

Bioz

Keywords

最近チェックした製品

IC₅₀ & Target