Diadenosine pentaphosphate

Diadenosine pentaphosphate (100 μM) elevates the intracellular calcium level of cultured human fetal astrocytes to 980 nM via P2 purinergic receptor-mediated extracellular calcium influx, as well as calcium release from IP₃-sensitive and ryanodine-sensitive intracellular calcium stores^[1].
Diadenosine pentaphosphate (100 μM; 5 sec) increases the production of IP₃ in cultured human fetal astrocytes by approximately 2-fold^[1].
Diadenosine pentaphosphate (10 μM) activates the I_KACh current in isolated guinea pig atrial myocytes by stimulating P1 receptors^[2].
Diadenosine pentaphosphate (100 μM) induces local, transient increases in intracellular calcium in distal dendrites and dendritic growth cones of E18 mouse hippocampal neurons cultured in vitro, with no effect on calcium levels in axons or somatodendritic regions^[5].
Diadenosine pentaphosphate (100 μM; 72 h) exerts a negative regulatory effect on dendrite growth and quantity in E18 mouse hippocampal neurons cultured in vitro (in phenol red-free medium). After treatment with 100 μM for 72 h, it reduces the total dendrite length by 28.7% and the number of dendrites by 28.1%, but has no effect on axon length^[5].
Diadenosine pentaphosphate (100 μM)​ reduces dendritic length and number in cultured E18 mouse hippocampal neurons. Overexpression of P2X1 mimics this effect, while shRNA knockdown of P2X1 reverses the reduction in dendrite number but fails to rescue the decrease in dendrite length^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.