Avasimibe sodium
Based on 20 publication(s) in Google Scholar
Avasimibe sodium (CI-1011 sodium; PD-148515 sodium) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively. Avasimibe sodium can be used for the research of prostate cancer.
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- CAS 番号: 166518-61-2
- 分子式: C29H43NNaO4S
- 分子量:524.72
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Avasimibe sodium
More- Nat Commun. 2025 Dec 19. [Abstract]
- Metabolism. 2021 Oct:123:154861. [Abstract]
- Redox Biol. 2023 Jun:62:102678. [Abstract]
- Cell Mol Biol Lett. 2025 Nov 24;30(1):140. [Abstract]
- Cell Death Dis. 2025 Apr 14;16(1):291. [Abstract]
- Cell Death Dis. 2021 Mar 10;12(3):254. [Abstract]
- Phytomedicine. 2025 Nov 25:148:157332. [Abstract]
- Cancer Cell Int. 2021 Aug 30;21(1):461. [Abstract]
- Int J Mol Sci. 2026 Mar 11;27(6):2587. [Abstract]
- Int Immunopharmacol. 2026 Jan 15:169:115973. [Abstract]
- Biomolecules. 2022 Jan 31;12(2):237. [Abstract]
- Biomolecules. 2021 Jun 8;11(6):853. [Abstract]
- Cancer Sci. 2024 Jan;115(1):48-58. [Abstract]
- Aquat Toxicol. 2026 Jun:295:107814. [Abstract]
- Biochem Biophys Res Commun. 2026 Jan 1:794:153070. [Abstract]
- Oncol Lett. 2019 Aug;18(2):1548-1556. [Abstract]
- bioRxiv. 2026 Jun 11:2026.06.10.731372. [Abstract]
- bioRxiv. 2026 Apr 4:2026.04.03.716381. [Abstract]
- bioRxiv. 2025 Jun 15:2025.06.12.659424. [Abstract]
- Biomed Pharmacother. 2020 Oct:130:110508. [Abstract]
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Cell Proliferation/Viability Assay
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RT-PCR
生物活性
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ACAT1 24 μM (IC50) |
ACAT2 9.2 μM (IC50) |
Avasimibe (0-80 μM; 1-3 days) sodium reduces proliferation in the prostate cancer (PCa) cells[2].
Avasimibe (10 and 20 μM; 48 h) sodium reduces the expression of β-catenin, Vimentin, N-cadherin, Snail and MMP9, which are tightly associated with epithelial-mesenchymal transition (EMT)[2].
Avasimibe (10 and 20 μM) sodium trigger cell cycle arrest via the E2F-1 signalling pathway in prostate cancer. Avasimibe sodium induces G1 phase cell cycle arrest of PCa cells[2].
Avasimibe (10 and 20 μM) sodium inhibits the metastasis of PCa cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PCa cells (PC-3 and DU 145)
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Concentration:0, 0.25, 5, 10, 20, 40 and 80 µM
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Incubation Time:1, 2, and 3 days
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Result:Dose dependently inhibited PC-3 and DU 145 cell viability.
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Cell Line:PCa cells (PC-3 and DU 145)
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Concentration:10 and 20 µM
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Incubation Time:48 hours
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Result:Reduced protein levels of EMT-related proteins (β-catenin, Vimentin, N-cadherin, Snail, MMP9 and E-cadherin).
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Cell Line:PCa cells (PC-3 and DU 145)
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Concentration:10 and 20 µM
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Incubation Time:48 hours
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Result:Induced G1 phase cycle arrest and altered the G1 phase-related protein levels in PCa cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SPF male mice (BALB/c-nude, 4 weeks old) bearing PCa cells[2]
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Dosage:30 mg/kg
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Administration:Intraperitoneally injected for 7 weeks
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Result:Reduced tumour volume compared with that of the control group. Inhibited PCa growth and migration in vivo.
化学情報
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CAS 番号 166518-61-2
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分子量 524.72
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分子式 C29H43NNaO4S
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SMILES
[Na].O=C(NS(=O)(=O)OC=1C(=CC=CC1C(C)C)C(C)C)CC=2C(=CC(=CC2C(C)C)C(C)C)C(C)C
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別名
CI-1011 sodium; PD-148515 sodium
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (20)
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Journal Impact Factor
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Most Recent
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Nat Commun
IDH2 lactylation promotes angiogenesis in murine diabetic myocardial infarction via blocking Cav1-eNOS interaction. [Abstract]2025 Dec 19. PMID: 41419771
Avasimibe sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 19. [Abstract]
Avasimibe (20 μM; 24 h). Western blot analysis of the expression levels of ACAT1 and IDH2-K272la in CMECs treated with the ACAT1 inhibitor Avasimibe under NOD and HOD stimulation.
Avasimibe sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 19. [Abstract]
Avasimibe (20 μM; 24 h). Coimmunoprecipitation experiment assessing the binding capacity of Cav1 with IDH2 and eNOS in CMECs treated with the ACAT1 inhibitor Avasimibe under NOD and HOD stimulation.
Avasimibe sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 19. [Abstract]
Avasimibe (20 μM; 24 h). Evaluation of tube formation, EdU proliferation, and NO production capabilities of CMECs treated with the ACAT1 inhibitor Avasimibe under HOD stimulation.
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Metabolism
Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake. [Abstract]2021 Oct:123:154861. PMID: 34371065 -
Redox Biol
Accumulated cholesterol protects tumours from elevated lipid peroxidation in the microenvironment. [Abstract]2023 Jun:62:102678. PMID: 36940607 -
Cell Mol Biol Lett
Abnormal cholesterol-cholesteryl ester metabolism impairs mouse oocyte quality during ovarian aging. [Abstract]2025 Nov 24;30(1):140. PMID: 41286604 -
Cell Death Dis
A targetable antioxidant defense mechanism to EZH2 inhibitors enhances tumor cell vulnerability to ferroptosis. [Abstract]2025 Apr 14;16(1):291. PMID: 40229247 -
Cell Death Dis
CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway. [Abstract]2021 Mar 10;12(3):254. PMID: 33692340 -
Phytomedicine
Piperine targets SOAT1 to inhibit the progression of esophageal squamous cell carcinoma via ferroptosis. [Abstract]2025 Nov 25:148:157332. PMID: 41061292 -
Cancer Cell Int
The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer. [Abstract]2021 Aug 30;21(1):461. PMID: 34461908 -
Int J Mol Sci
2026 Mar 11;27(6):2587. PMID: 41898448 -
Int Immunopharmacol
ACAT1 inhibitor Avasimibe suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via CKB/PI3K-AKT signaling. [Abstract]2026 Jan 15:169:115973. PMID: 41352098 -
Biomolecules
2022 Jan 31;12(2):237. PMID: 35204738 -
Biomolecules
Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells. [Abstract]2021 Jun 8;11(6):853. PMID: 34201030 -
Cancer Sci
SCD1 inhibition enhances the effector functions of CD8+ T cells via ACAT1-dependent reduction of esterified cholesterol. [Abstract]2024 Jan;115(1):48-58. PMID: 37879607 -
Aquat Toxicol
Is acyl-CoA cholesterol acyltransferase 2 the enzyme responsible for the esterification of okadaic acid in bivalves?. [Abstract]2026 Jun:295:107814. PMID: 41935504 -
Biochem Biophys Res Commun
7-dehydrocholesterol promotes CCL2-secretion from porcine skeletal muscle satellite cells, enhancing the migration of preadipocytes. [Abstract]2026 Jan 1:794:153070. PMID: 41344212 -
Oncol Lett
Effect of inhibiting ACAT-1 expression on the growth and metastasis of Lewis lung carcinoma. [Abstract]2019 Aug;18(2):1548-1556. PMID: 31423222 -
bioRxiv
2026 Jun 11:2026.06.10.731372. PMID: 42327215 -
bioRxiv
2026 Apr 4:2026.04.03.716381. PMID: 41959418 -
bioRxiv
Inhibition of Acyl-CoA: Cholesterol Acyltransferase 1 Promotes Shedding of Soluble TREM2 and LRP1-Dependent Phagocytosis of Amyloid β Protein in Microglia. [Abstract]2025 Jun 15:2025.06.12.659424. PMID: 40661651 -
Biomed Pharmacother
Avasimibe inhibits the proliferation, migration and invasion of glioma cells by suppressing linc00339. [Abstract]2020 Oct:130:110508. PMID: 32682982
Avasimibe sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Oct:130:110508. [Abstract]
Avasimibe (7.5 μM; 0-72 h). Inhibitory effects of Avasimibe on cell viability of T98 G and LN229 at different times.
Avasimibe sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Oct:130:110508. [Abstract]
qRT-PCR data showing the expression of linc00339 in T98 G or LN229 cells treated with linc00339 plasmid, Avasimibe (7.5 μM for 48 h) alone or in combination with linc00339 plasmids.
Avasimibe sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Oct:130:110508. [Abstract]
Colony formation assays showing the proliferation capacity of T98 G or LN229 cells treated with linc00339 plasmid, Avasimibe (7.5 μM for 48 h) alone or in combination with linc00339 plasmids.
Avasimibe sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Oct:130:110508. [Abstract]
Avasimibe (7.5 μM for 48 h). LN229 cells treated with Avasimibe or combined with linc00339 plasmid were subcutaneously injected into the nude mice. Tumour formation in nude mice.
Avasimibe sodium purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Oct:130:110508. [Abstract]
Transwell assays showing the invasion capacity of T98 G or LN229 cells treated with linc00339 plasmid, Avasimibe (7.5 μM for 48 h) alone or in combination with linc00339 plasmids.
純度とドキュメンテーション
参考文献
[1]. Taichi Ohshiro,et al. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15. [Content Brief]
[2]. Kangping Xiong, et al. The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer.Cancer Cell Int. 2021 Aug 30;21(1):461. [Content Brief]
Calculators
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Avasimibe sodium 関連分類
HY-13215A 関連分類
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